Jonathan A. Javitch, MD, PhD
Lieber Professor of Experimental Therapeutics in Psychiatry and Professor of Molecular Pharmacology and Therapeutics at Columbia University
Location: New York, NY
United States
Dr. Jonathan Javitch is the Lieber Professor of Psychiatry and Professor of Molecular Pharmacology and Therapeutics at Columbia University, and Chief of the Division of Molecular Therapeutics at the New York State Psychiatric Institute. His research focuses on G protein-coupled receptor structure, function, and regulation in neuropsychiatric illness, with particular emphasis on dopamine, opioid, and glutamate systems.
Dr. Javitch earned his M.D. and Ph.D. with Solomon Snyder at Johns Hopkins School of Medicine, where he led the discovery that MPTP neurotoxicity is mediated by the dopamine transporter, helping establish a widely used model of Parkinson's disease. He completed postdoctoral training with Arthur Karlin at Columbia University.
Current work uses single-molecule imaging and other biophysical approaches to investigate GPCR heteromeric complexes and signaling mechanisms, including the action of tianeptine as a mu opioid receptor agonist in depression. Dr. Javitch has been continuously funded by NIH for over 30 years.
Associated Grants
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CLEAR-PD: Clearance via Lymphatics & Endocytic Alpha-Synuclein Receptors in Parkinson’s Disease
2026