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  • Mechanism of parkin activation by PINK1
    2018
    Summary Details
    OPEN
    Title: Mechanism of parkin activation by PINK1
    Author(s): Christina Gladkova, Sarah Maslen, Mark Skehel, David Komander
    Journal Name: Nature
    Publisher: Springer Science and Business Media LLC
    Vol: 559
    Issue #: 7714
    Start Page: 410
    End Page: 414
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1038/s41586-018-0224-x
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6071873
    Citation Count: 326
  • Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
    2017
    Summary Details
    OPEN
    Title: Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
    Author(s): Zhentao Zhang, Seong Su Kang, Xia Liu, Eun Hee Ahn, Zhaohui Zhang, Li He, P. Michael Iuvone, Duc M. Duong, Nicholas T. Seyfried, Matthew J. Benskey, Fredric P. Manfredsson, Lingjing Jin, Yi Sun, Jian‐Zhi Wang, Keqiang Ye
    Journal Name: Nature Structural & Molecular Biology
    Publisher: Springer Science and Business Media LLC
    Vol: 24
    Issue #: 8
    Start Page: 632
    End Page: 642
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1038/nsmb.3433
    Best OA location URL: https://www.nature.com/articles/nsmb.3433.pdf
    Citation Count: 169
  • Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease
    2012
    Summary Details
    OPEN
    Title: Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease
    Author(s): Arthur G. Fitzmaurice, Shannon Rhodes, Aaron Lulla, Niall Murphy, Hoa A. Lam, Kelley C. O’Donnell, Lisa M. Barnhill, John E. Casida, Myles Cockburn, Alvaro Sagasti, Mark Stahl, Nigel T. Maidment, Beate Ritz, Jeff M. Bronstein
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Vol: 110
    Issue #: 2
    Start Page: 636
    End Page: 641
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1220399110
    Best OA location URL: https://www.pnas.org/content/pnas/110/2/636.full.pdf
    Citation Count: 191
  • Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
    2014
    Summary Details
    OPEN
    Title: Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
    Author(s): Amanda N. Sacino, Mieu Brooks, M. Albert Thomas, Alex B. McKinney, Sooyeon Lee, Robert W. Regenhardt, Nicholas H. McGarvey, Jacob I. Ayers, Lucia Notterpek, David Borchelt, Todd E. Golde, Benoit I. Giasson
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Vol: 111
    Issue #: 29
    Start Page: 10732
    End Page: 10737
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1321785111
    Best OA location URL: https://www.pnas.org/content/pnas/111/29/10732.full.pdf
    Citation Count: 301
  • Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease
    2015
    Summary Details
    OPEN
    Title: Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease
    Author(s): Chun‐Hyung Kim, Baek‐Soo Han, Jisook Moon, Deog-Joong Kim, Joon Shin, S. S. Rajan, Quoc Toan Nguyen, Mi‐Jin Sohn, Won‐Gon Kim, Min-Joon Han, Inhye Jeong, Kyoung‐Shim Kim, Eun-Hye Lee, Yupeng Tu, Jacqueline L. Naffin-Olivos, Chang‐Hwan Park, Dagmar Ringe, Ho Sup Yoon, Gregory A. Petsko, Kwang‐Soo Kim
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Vol: 112
    Issue #: 28
    Start Page: 8756
    End Page: 8761
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1509742112
    Best OA location URL: https://www.pnas.org/content/pnas/112/28/8756.full.pdf
    Citation Count: 184
  • Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
    2016
    Summary Details
    OPEN
    Title: Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
    Author(s): Wei Wang, Linh Hồ Thùy Nguyễn, Christopher Burlak, Fariba Chegini, Feng Guo, Tim Chataway, Shulin Ju, Oriana S. Fisher, David W. Miller, Debajyoti Datta, Fang Wu, Chun-Xiang Wu, Anuradha Landeru, James A. Wells, Mark Cookson, Matthew B. Boxer, Craig J. Thomas, Wei Gai, Dagmar Ringe, Gregory A. Petsko, Quyen Q. Hoang
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Vol: 113
    Issue #: 34
    Start Page: 9587
    End Page: 9592
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1610099113
    Best OA location URL: https://www.pnas.org/content/pnas/113/34/9587.full.pdf
    Citation Count: 238
  • The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
    2004
    Summary Details
    OPEN
    Title: The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
    Author(s): Luigi Zecca, Antonella Stroppolo, Alberto Gatti, Davide Tampellini, Marco Toscani, Mario Gallorini, G. Giaveri, Paolo Arosio, Paolo Santambrogio, Ruggero G. Fariello, Erdem Karatekin, Mark H. Kleinman, Nicholas J. Turro, Oleh Hornykiewicz, Fabio A. Zucca
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Vol: 101
    Issue #: 26
    Start Page: 9843
    End Page: 9848
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0403495101
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/470762
    Citation Count: 461
  • LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
    2016
    Summary Details
    OPEN
    Title: LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
    Author(s): Tomoki Kuwahara, Keiichi Inoue, Vivette D. D’Agati, Tetta Fujimoto, Tomoya Eguchi, Shamol Saha, Benjamin Wolozin, Takeshi Iwatsubo, Asa Abeliovich
    Journal Name: Scientific Reports
    Publisher: Springer Science and Business Media LLC
    Vol: 6
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/srep29945
    Best OA location URL: https://www.nature.com/articles/srep29945.pdf
    Citation Count: 127
  • Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice
    2017
    Summary Details
    OPEN
    Title: Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice
    Author(s): Mantia Karampetsou, Mustafa T. Ardah, Maria Semitekolou, Alexia Polissidis, Martina Samiotaki, Maria Kalomoiri, Nour K. Majbour, Georgina Xanthou, Omar M. A. El‐Agnaf, Kostas Vekrellis
    Journal Name: Scientific Reports
    Publisher: Springer Science and Business Media LLC
    Vol: 7
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41598-017-15813-8
    Best OA location URL: https://www.nature.com/articles/s41598-017-15813-8.pdf
    Citation Count: 138
  • Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
    2018
    Summary Details
    OPEN
    Title: Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
    Author(s): Lingyan Ping, Duc M. Duong, Luming Yin, Marla Gearing, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
    Journal Name: Scientific Data
    Publisher: Springer Science and Business Media LLC
    Vol: 5
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/sdata.2018.36
    Best OA location URL: https://www.nature.com/articles/sdata201836.pdf
    Citation Count: 214
  • Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases
    2016
    Summary Details
    OPEN
    Title: Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases
    Author(s): Mariet Allen, Minerva M. Carrasquillo, Cory C. Funk, Ben Heavner, Fanggeng Zou, Curtis Younkin, Jeremy D. Burgess, High-Seng Chai, Julia E. Crook, James A. Eddy, Hong‐Dong Li, Ben Logsdon, Mette A. Peters, Kristen K. Dang, Xue Wang, Daniel Serie, Chen Wang, Thuy Nguyen, Sarah Lincoln, Kimberly G. Malphrus, Gina Bisceglio, Li Ma, Todd E. Golde, Lara M. Mangravite, Yan W. Asmann, Nathan D. Price, Ronald Petersen, Neill R. Graff‐Radford, Dennis W. Dickson, Steven G. Younkin, Nilüfer Ertekin‐Taner
    Journal Name: Scientific Data
    Publisher: Springer Science and Business Media LLC
    Vol: 3
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/sdata.2016.89
    Best OA location URL: https://www.nature.com/articles/sdata201689.pdf
    Citation Count: 427
  • Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry
    2014
    Summary Details
    OPEN
    Title: Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry
    Author(s): John F. Kellie, Richard E. Higgs, John Ryder, Anthony Major, Thomas G. Beach, Charles H. Adler, Kalpana Merchant, Michael D. Knierman
    Journal Name: Scientific Reports
    Publisher: Springer Science and Business Media LLC
    Vol: 4
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-sa
    DOI - Digital Object Identifier: 10.1038/srep05797
    Best OA location URL: https://www.nature.com/articles/srep05797.pdf
    Citation Count: 155
  • Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson’s disease model
    2018
    Summary Details
    OPEN
    Title: Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson’s disease model
    Author(s): Diptaman Chatterjee, Mansi A. Bhatt, David Butler, Erwin De Genst, Christopher M. Dobson, Anne Messer, Jeffrey H. Kordower
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 4
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41531-018-0062-4
    Best OA location URL: https://www.nature.com/articles/s41531-018-0062-4.pdf
    Citation Count: 78
  • Prevalence of Parkinson’s disease across North America
    2018
    Summary Details
    OPEN
    Title: Prevalence of Parkinson’s disease across North America
    Author(s): Connie Marras, James C. Beck, James H. Bower, Eric Roberts, Beate Ritz, G. Webster Ross, Robert D. Abbott, Rodolfo Savica, Stephen K. Van Den Eeden, Allison W. Willis, CM Tanner
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 4
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41531-018-0058-0
    Best OA location URL: https://escholarship.org/uc/item/1qs1g07m
    Citation Count: 844
  • LRRK2 levels in immune cells are increased in Parkinson’s disease
    2017
    Summary Details
    OPEN
    Title: LRRK2 levels in immune cells are increased in Parkinson’s disease
    Author(s): Darcie A. Cook, George T. Kannarkat, Amarallys F. Cintron, Laura M. Butkovich, Kyle Fraser, Jianjun Chang, Nelly Grigoryan, Stewart A. Factor, Andrew B. West, Jeremy M. Boss, Malú G. Tansey
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 3
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41531-017-0010-8
    Best OA location URL: https://www.nature.com/articles/s41531-017-0010-8.pdf
    Citation Count: 237
  • Neurologist care in Parkinson disease
    2011
    Summary Details
    OPEN
    Title: Neurologist care in Parkinson disease
    Author(s): Allison W. Willis, Mario Schootman, Bradley Evanoff, Joel S. Perlmutter, Brad A. Racette
    Journal Name: Neurology
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Vol: 77
    Issue #: 9
    Start Page: 851
    End Page: 857
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1212/wnl.0b013e31822c9123
    Best OA location URL: https://n.neurology.org/content/neurology/77/9/851.full.pdf
    Citation Count: 265
  • “On” state freezing of gait in Parkinson disease
    2012
    Summary Details
    OPEN
    Title: “On” state freezing of gait in Parkinson disease
    Author(s): Alberto J. Espay, Alfonso Fasano, Bart F.L. van Nuenen, Megan Payne, Anke H. Snijders, Bastiaan R. Bloem
    Journal Name: Neurology
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Vol: 78
    Issue #: 7
    Start Page: 454
    End Page: 457
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1212/wnl.0b013e3182477ec0
    Best OA location URL:
    Citation Count: 201
  • Evidence-based guideline: Pharmacologic treatment of chorea in Huntington disease [RETIRED]
    2012
    Summary Details
    OPEN
    Title: Evidence-based guideline: Pharmacologic treatment of chorea in Huntington disease [RETIRED]
    Author(s): Melissa J. Armstrong, Janis M. Miyasaki
    Journal Name: Neurology
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Vol: 79
    Issue #: 6
    Start Page: 597
    End Page: 603
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1212/wnl.0b013e318263c443
    Best OA location URL: https://n.neurology.org/content/neurology/79/6/597.full.pdf
    Citation Count: 159
  • The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling
    2012
    Summary Details
    OPEN
    Title: The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling
    Author(s): Nicolas Dzamko, Francisco Iñesta-Vaquera, Jiazhen Zhang, Chengsong Xie, Huaibin Cai, J. Simon C. Arthur, Li Tan, Hwanguen Choi, Nathanael S. Gray, Philip Cohen, Patrick G. A. Pedrioli, Kristopher Clark, Dario R. Alessi
    Journal Name: PLoS ONE
    Publisher: Public Library of Science (PLoS)
    Vol: 7
    Issue #: 6
    Start Page: e39132
    End Page: e39132
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc0
    DOI - Digital Object Identifier: 10.1371/journal.pone.0039132
    Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039132&type=printable
    Citation Count: 205
  • Plasticity in Early Alzheimer Disease
    2011
    Summary Details
    OPEN
    Title: Plasticity in Early Alzheimer Disease
    Author(s): Nikki L. Hill, Ann Kolanowski, David Gill
    Journal Name: Topics in Geriatric Rehabilitation
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Vol: 27
    Issue #: 4
    Start Page: 257
    End Page: 267
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1097/tgr.0b013e31821e588e
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3419487
    Citation Count: 38
  • Hypersynchrony despite pathologically reduced beta oscillations in patients with Parkinson's disease: a pharmaco-magnetoencephalography study
    2014
    Summary Details
    OPEN
    Title: Hypersynchrony despite pathologically reduced beta oscillations in patients with Parkinson's disease: a pharmaco-magnetoencephalography study
    Author(s): Elizabeth Heinrichs‐Graham, Max J. Kurz, Katherine M. Becker, Pamela M. Santamaria, Howard E. Gendelman, Tony W. Wilson
    Journal Name: Journal of Neurophysiology
    Publisher: American Physiological Society
    Vol: 112
    Issue #: 7
    Start Page: 1739
    End Page: 1747
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1152/jn.00383.2014
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4157173
    Citation Count: 82
  • Sarcopenia and impairment in cognitive and physical performance
    2015
    Summary Details
    OPEN
    Title: Sarcopenia and impairment in cognitive and physical performance
    Author(s): Magdalena I. Tolea, James E. Galvin
    Journal Name: Clinical Interventions in Aging
    Publisher: Informa UK Limited
    Vol:
    Issue #:
    Start Page: 663
    End Page: 663
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.2147/cia.s76275
    Best OA location URL: https://www.dovepress.com/getfile.php?fileID=24358
    Citation Count: 98
  • Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo
    2014
    Summary Details
    OPEN
    Title: Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo
    Author(s): Edward Rockenstein, Silke Nuber, Cassia Overk, Kiren Ubhi, Michael Mante, Christina Patrick, Anthony Adame, Margarita Trejo-Morales, Juan Gerez, Paola Picotti, Poul Henning Jensen, Silvia Campioni, Roland Riek, Jürgen Winkler, Fred H. Gage, Beate Winner, Eliezer Masliah
    Journal Name: Brain
    Publisher: Oxford University Press (OUP)
    Vol: 137
    Issue #: 5
    Start Page: 1496
    End Page: 1513
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1093/brain/awu057
    Best OA location URL: https://academic.oup.com/brain/article-pdf/137/5/1496/11140606/awu057.pdf
    Citation Count: 218
  • CSF xanthine, homovanillic acid, and their ratio as biomarkers of Parkinson's disease
    2011
    Summary Details
    OPEN
    Title: CSF xanthine, homovanillic acid, and their ratio as biomarkers of Parkinson's disease
    Author(s): Peter A. LeWitt, Lonni Schultz, Peggy Auinger, Mei Lü
    Journal Name: Brain Research
    Publisher: Elsevier BV
    Vol: 1408
    Issue #:
    Start Page: 88
    End Page: 97
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.brainres.2011.06.057
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4120020
    Citation Count: 74
  • Dysrhythmia of timed movements in Parkinson׳s disease and freezing of gait
    2015
    Summary Details
    OPEN
    Title: Dysrhythmia of timed movements in Parkinson׳s disease and freezing of gait
    Author(s): Christopher Tolleson, David G. Dobolyi, Olivia C. Roman, Kristen Kanoff, Scott J. Barton, Scott A. Wylie, Michael Kubovy, Daniel O. Claassen
    Journal Name: Brain Research
    Publisher: Elsevier BV
    Vol: 1624
    Issue #:
    Start Page: 222
    End Page: 231
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.brainres.2015.07.041
    Best OA location URL: http://doi.org/10.1016/j.brainres.2015.07.041
    Citation Count: 27
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