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3691 - 3700 of 8808 Results
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Year
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  • Untwisted α-Synuclein Filaments Formed in the Presence of Lipid Vesicles
    2022
    Summary Details
    OPEN
    Title: Untwisted α-Synuclein Filaments Formed in the Presence of Lipid Vesicles
    Author(s): Anvesh K. R. Dasari, Lucas Dillard, Sujung Yi, Elizabeth Viverette, Alimohammad Hojjatian, Urmi Sengupta, Rakez Kayed, Kenneth A. Taylor, Mario J. Borgnia, Kwang Hun Lim
    Journal Name: Biochemistry
    Publisher: American Chemical Society (ACS)
    Vol: 61
    Issue #: 17
    Start Page: 1766
    End Page: 1773
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1021/acs.biochem.2c00283
    Best OA location URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10289115/pdf/nihms-1906828.pdf
    Citation Count: 9
  • Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
    2022
    Summary Details
    RESTRICTED
    Title: Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
    Author(s): David A. Candito, Vladimir Simov, Anmol Gulati, Solomon D. Kattar, Ryan Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Günaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul J. Ciaccio, Jennifer Piesvaux, Karin M. Otte, Matthew Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
    Journal Name: Journal of Medicinal Chemistry
    Publisher: American Chemical Society (ACS)
    Vol: 65
    Issue #: 24
    Start Page: 16801
    End Page: 16817
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1021/acs.jmedchem.2c01605
    Citation Count: 17
  • Association of Plasma and Cerebrospinal Fluid Alzheimer Disease Biomarkers With Race and the Role of Genetic Ancestry, Vascular Comorbidities, and Neighborhood Factors
    2022
    Summary Details
    OPEN
    Title: Association of Plasma and Cerebrospinal Fluid Alzheimer Disease Biomarkers With Race and the Role of Genetic Ancestry, Vascular Comorbidities, and Neighborhood Factors
    Author(s): Ihab Hajjar, Zhiyi Yang, Maureen Okafor, Chang Liu, Teresa Waligórska, Felicia C. Goldstein, Leslie M. Shaw
    Journal Name: JAMA Network Open
    Publisher: American Medical Association (AMA)
    Vol: 5
    Issue #: 10
    Start Page: e2235068
    End Page: e2235068
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1001/jamanetworkopen.2022.35068
    Best OA location URL: https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2797044/hajjar_2022_oi_220997_1664303851.08078.pdf
    Citation Count: 50
  • How Prolonged Isolation Affects People With Parkinson Disease During the COVID-19 Pandemic
    2022
    Summary Details
    OPEN
    Title: How Prolonged Isolation Affects People With Parkinson Disease During the COVID-19 Pandemic
    Author(s): Melissa Suran
    Journal Name: JAMA
    Publisher: American Medical Association (AMA)
    Vol: 327
    Issue #: 9
    Start Page: 801
    End Page: 801
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1001/jama.2022.1510
    Best OA location URL: https://jamanetwork.com/journals/jama/articlepdf/2789055/jama_suran_2022_mn_220006_1645750114.50702.pdf
    Citation Count: 6
  • Monitoring gait at home with radio waves in Parkinson’s disease: A marker of severity, progression, and medication response
    2022
    Summary Details
    RESTRICTED
    Title: Monitoring gait at home with radio waves in Parkinson’s disease: A marker of severity, progression, and medication response
    Author(s): Yingcheng Liu, Guo Zhang, Christopher G. Tarolli, Rumen Hristov, Stella Jensen-Roberts, Emma Waddell, Taylor Myers, Meghan Pawlik, Julia Soto, Renée Wilson, Yuzhe Yang, Timothy Nordahl, Karlo J. Lizárraga, Jamie Adams, Ruth B. Schneider, Karl Kieburtz, Terry D. Ellis, E. Ray Dorsey, Dina Katabi
    Journal Name: Science Translational Medicine
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 14
    Issue #: 663
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1126/scitranslmed.adc9669
    Citation Count: 57
  • Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease
    2022
    Summary Details
    RESTRICTED
    Title: Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease
    Author(s): Danna Jennings, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, Jennifer C. Sasaki, René Meisner, Dolores Diaz, Hilda Solanoy, Xiang Wang, Elvira Negrou, Vitaliy V. Bondar, Rajarshi Ghosh, Michael T. Maloney, Nicholas E. Propson, Yuda Zhu, Romeo Maciuca, Laura Harris, Angela Kay, Peter A. LeWitt, T. Alex King, Drew S. Kern, Aaron Ellenbogen, Ira Goodman, Andrew Siderowf, Jason Aldred, Omid Omidvar, Shababa T. Masoud, Sonnet S. Davis, Annie Arguello, Anthony A. Estrada, Javier de Vicente, Zachary K. Sweeney, Giuseppe Astarita, Marie T. Borin, Bradley K. Wong, Harvey Wong, Hoang N. Nguyen, Kimberly Scearce‐Levie, Carole Ho, Matthew D. Troyer
    Journal Name: Science Translational Medicine
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 14
    Issue #: 648
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1126/scitranslmed.abj2658
    Citation Count: 192
  • Library-Derived Peptide Aggregation Modulators of Parkinson’s Disease Early-Onset α-Synuclein Variants
    2022
    Summary Details
    OPEN
    Title: Library-Derived Peptide Aggregation Modulators of Parkinson’s Disease Early-Onset α-Synuclein Variants
    Author(s): Kathryn J.C. Watt, Richard M. Meade, Robert J. Williams, Jody M. Mason
    Journal Name: ACS Chemical Neuroscience
    Publisher: American Chemical Society (ACS)
    Vol: 13
    Issue #: 12
    Start Page: 1790
    End Page: 1804
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1021/acschemneuro.2c00190
    Best OA location URL: https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.2c00190
    Citation Count: 5
  • A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity
    2022
    Summary Details
    OPEN
    Title: A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity
    Author(s): Senthil T. Kumar, Anne‐Laure Mahul‐Mellier, Ramanath Narayana Hegde, Gwladys Rivière, Rani Moons, Alain Ibáñez de Opakua, Pedro Magalhães, Iman Rostami, Sonia Donzelli, Frank Sobott, Markus Zweckstetter, Hilal A. Lashuel
    Journal Name: Science Advances
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 8
    Issue #: 17
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1126/sciadv.abn0044
    Best OA location URL: https://www.science.org/doi/pdf/10.1126/sciadv.abn0044?download=true
    Citation Count: 35
  • Comprehensive genetic diagnosis of tandem repeat expansion disorders with programmable targeted nanopore sequencing
    2022
    Summary Details
    OPEN
    Title: Comprehensive genetic diagnosis of tandem repeat expansion disorders with programmable targeted nanopore sequencing
    Author(s): Igor Stevanovski, Sanjog R. Chintalaphani, Hasindu Gamaarachchi, James M. Ferguson, Sandy S. Pineda, Carolin K. Scriba, Michel Tchan, Victor S.C. Fung, Karl Ng, Andrea Cortese, Henry Houlden, Carol Dobson‐Stone, Lauren Fitzpatrick, Glenda M. Halliday, Gianina Ravenscroft, Mark R. Davis, Nigel G. Laing, Avi Fellner, Marina Kennerson, Kishore R. Kumar, Ira W. Deveson
    Journal Name: Science Advances
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 8
    Issue #: 9
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1126/sciadv.abm5386
    Best OA location URL: https://doi.org/10.1126/sciadv.abm5386
    Citation Count: 143
  • Mapping microstructural gradients of the human striatum in normal aging and Parkinson’s disease
    2022
    Summary Details
    OPEN
    Title: Mapping microstructural gradients of the human striatum in normal aging and Parkinson’s disease
    Author(s): Elior Drori, Shai Berman, Aviv Mezer
    Journal Name: Science Advances
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 8
    Issue #: 28
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1126/sciadv.abm1971
    Best OA location URL: https://doi.org/10.1126/sciadv.abm1971
    Citation Count: 38
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