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5981 - 5990 of 8818 Results
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  • Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion
    2020
    Summary Details
    OPEN
    Title: Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion
    Author(s): Sangwoo Ham, Seung Pil Yun, Hyojung Kim, Donghoon Kim, Bo Am Seo, Heejeong Kim, Jeong-Yong Shin, Mohammad Aasif Dar, Gum Hwa Lee, Yun Il Lee, Doyeun Kim, Sung‐Hoon Kim, Hee-Seok Kweon, Joo‐Ho Shin, Han Seok Ko, Yunjong Lee
    Journal Name: Science Translational Medicine
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 12
    Issue #: 569
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1126/scitranslmed.aax0091
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8082540
    Citation Count: 21
  • LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits
    2020
    Summary Details
    OPEN
    Title: LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits
    Author(s): Marco A. S. Baptista, Kalpana Merchant, Ted Barrett, Sakshi Bhargava, Dianne K. Bryce, J. Michael Ellis, Anthony A. Estrada, Matthew Fell, Brian Fiske, Reina N. Fuji, Paul Galatsis, Anastasia G. Henry, Sue Hill, Warren D. Hirst, Christopher Houle, Matthew Kennedy, Xingrong Liu, Matthew L. Maddess, Carrie G. Markgraf, Hong Mei, William A. Meier, Elie Needle, Stephen Ploch, Christopher M. Royer, Karin Rudolph, Alok Sharma, Antonia F. Stepan, Stefanus J. Steyn, Craig Trost, Zhizhang Yin, Hongshi Yu, Xiang Wang, Todd Sherer
    Journal Name: Science Translational Medicine
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 12
    Issue #: 540
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1126/scitranslmed.aav0820
    Citation Count: 114
  • A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson’s disease
    2020
    Summary Details
    RESTRICTED
    Title: A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson’s disease
    Author(s): Ibrahim Boussaad, Carolin D. Obermaier, Zoé Hanss, Dheeraj Reddy Bobbili, Silvia Bolognin, Enrico Glaab, Katarzyna Wicher, Nicole Weisschuh, Laura De Conti, Caroline May, Florian Giesert, Dajana Großmann, Annika Lambert, Susanne Kirchen, Maria Biryukov, Lena F. Burbulla, François Massart, Jill Bohler, Gérald Cruciani, Benjamin Schmid, Annerose Kurz-Drexler, Patrick May, Stefano Duga, Christine Klein, Jens C. Schwamborn, Katrin Marcus, Dirk Woitalla, Daniela M. Vogt Weisenhorn, Wolfgang Wurst, Marco Baralle, Dimitri Krainc, Thomas Gasser, Bernd Wissinger, Rejko Krüger
    Journal Name: Science Translational Medicine
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 12
    Issue #: 560
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1126/scitranslmed.aau3960
    Best OA location URL: http://orbilu.uni.lu/handle/10993/44767
    Citation Count: 41
  • Selective Fluorogenic β-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates
    2020
    Summary Details
    OPEN
    Title: Selective Fluorogenic β-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates
    Author(s): Matthew C. Deen, Cameron Proceviat, Xiaoyang Shan, Liang Wu, David L. Shen, G.J. Davies, David J. Vocadlo
    Journal Name: ACS Chemical Biology
    Publisher: American Chemical Society (ACS)
    Vol: 15
    Issue #: 4
    Start Page: 824
    End Page: 829
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1021/acschembio.9b01044
    Citation Count: 10
  • A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels
    2020
    Summary Details
    OPEN
    Title: A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels
    Author(s): Garry Cooper, Soosung Kang, Tamara Perez‐Rosello, Jaime N. Guzmán, Daniel J. Galtieri, Zhong Xie, Jyothisri Kondapalli, Jack Mordell, Richard B. Silverman, D. James Surmeier
    Journal Name: ACS Chemical Biology
    Publisher: American Chemical Society (ACS)
    Vol: 15
    Issue #: 9
    Start Page: 2539
    End Page: 2550
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1021/acschembio.0c00577
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7502546
    Citation Count: 17
  • Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro
    2020
    Summary Details
    OPEN
    Title: Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro
    Author(s): Pierluigi Valente, Darya Kiryushko, Silvio Sacchetti, Pedro Machado, Claire M. Cobley, Vincenzo Mangini, Alexandra E. Porter, Joachim P. Spatz, Roland A. Fleck, Fabio Benfenati, Roberto Fiammengo
    Journal Name: ACS Nano
    Publisher: American Chemical Society (ACS)
    Vol: 14
    Issue #: 6
    Start Page: 6866
    End Page: 6877
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1021/acsnano.0c00866
    Best OA location URL: https://ndownloader.figstatic.com/files/22969427
    Citation Count: 14
  • Virus Bioresistor (VBR) for Detection of Bladder Cancer Marker DJ-1 in Urine at 10 pM in One Minute
    2020
    Summary Details
    OPEN
    Title: Virus Bioresistor (VBR) for Detection of Bladder Cancer Marker DJ-1 in Urine at 10 pM in One Minute
    Author(s): Apurva Bhasin, Emily C. Sanders, Joshua Ziegler, Jeffrey S. Briggs, Nicholas P. Drago, Aisha Attar, Alicia M. Santos, Marie Y. True, Alana F. Ogata, Debora V. Yoon, Sudipta Majumdar, Andrew Wheat, Shae V. Patterson, Gregory A. Weiss, Reginald M. Penner
    Journal Name: Analytical Chemistry
    Publisher: American Chemical Society (ACS)
    Vol: 92
    Issue #: 9
    Start Page: 6654
    End Page: 6666
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1021/acs.analchem.0c00534
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7266010
    Citation Count: 27
  • Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils
    2020
    Summary Details
    OPEN
    Title: Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils
    Author(s): Dan E. Adolfsson, Mohit Tyagi, Pardeep Singh, Adrian Deuschmann, Jörgen Ådén, Anna L. Gharibyan, Sanduni Wasana Jayaweera, Anders E. G. Lindgren, Anders Olofsson, Fredrik Almqvist
    Journal Name: The Journal of Organic Chemistry
    Publisher: American Chemical Society (ACS)
    Vol: 85
    Issue #: 21
    Start Page: 14174
    End Page: 14189
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1021/acs.joc.0c01699
    Best OA location URL: https://pubs.acs.org/doi/pdf/10.1021/acs.joc.0c01699
    Citation Count: 21
  • A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores
    2020
    Summary Details
    OPEN
    Title: A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores
    Author(s): Lisa-Maria Needham, Judith Weber, Colin M. Pearson, T. Dung, Felix Gorka, Guanpeng Lyu, Sarah E. Bohndiek, Thomas N. Snaddon, Steven F. Lee
    Journal Name: The Journal of Physical Chemistry Letters
    Publisher: American Chemical Society (ACS)
    Vol: 11
    Issue #: 19
    Start Page: 8406
    End Page: 8416
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1021/acs.jpclett.0c01549
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8741274
    Citation Count: 25
  • Choosing a Parkinson Disease Treatment
    2020
    Summary Details
    OPEN
    Title: Choosing a Parkinson Disease Treatment
    Author(s): Melissa J. Armstrong, Michael S. Okun
    Journal Name: JAMA
    Publisher: American Medical Association (AMA)
    Vol: 323
    Issue #: 14
    Start Page: 1420
    End Page: 1420
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1001/jama.2020.1224
    Best OA location URL: https://jamanetwork.com/journals/jama/articlepdf/2764458/jama_armstrong_2020_pg_200005.pdf
    Citation Count: 34
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