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  • Genome-wide case-only analysis of gene-gene interactions with known Parkinson’s disease risk variants reveals link between LRRK2 and SYT10
    2023
    Summary Details
    OPEN
    Title: Genome-wide case-only analysis of gene-gene interactions with known Parkinson’s disease risk variants reveals link between LRRK2 and SYT10
    Author(s): Milda Aleknonytė‐Resch, Joanne Trinh, Hampton L. Leonard, Sylvie Delcambre, Elsa Leitão, Dongbing Lai, Semra Smajić, Avi Orr‐Urtreger, Avner Thaler, Cornelis Blauwendraat, Arunabh Sharma, Mary B. Makarious, Jonggeol Jeff Kim, Julie Lake, Pegah Rahmati, Sandra Freitag‐Wolf, Philip Seibler, Tatiana Foroud, Andrew Singleton, Anne Grünewald, Frank J. Kaiser, Christine Klein, Michael Krawczak, Astrid Dempfle
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 9
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41531-023-00550-9
    Best OA location URL: https://www.nature.com/articles/s41531-023-00550-9.pdf
    Citation Count: 5
  • Structural basis for feedforward control in the PINK1/Parkin pathway
    2022
    Summary Details
    OPEN
    Title: Structural basis for feedforward control in the PINK1/Parkin pathway
    Author(s): Véronique Sauvé, George Sung, Emma J. MacDougall, Guennadi Kozlov, Anshu Saran, Rayan Fakih, Edward A. Fon, Kalle Gehring
    Journal Name: The EMBO Journal
    Publisher: Springer Science and Business Media LLC
    Vol: 41
    Issue #: 12
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.15252/embj.2021109460
    Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2021109460
    Citation Count: 21
  • Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2
    2018
    Summary Details
    OPEN
    Title: Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2
    Author(s): Dimitriοs Vlachakis, Nikolaos E. Labrou, Costas S. Iliopoulos, John Hardy, Patrick A. Lewis, Hardy J. Rideout, Daniah Trabzuni
    Journal Name: International Journal of Molecular Sciences
    Publisher: MDPI AG
    Vol: 19
    Issue #: 9
    Start Page: 2784
    End Page: 2784
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.3390/ijms19092784
    Best OA location URL: https://kclpure.kcl.ac.uk/ws/files/101872551/Insights_into_the_influence_Vlachakis_2018_GOLD_VoR.pdf
    Citation Count: 2
  • The Remote Assessment of Parkinsonism Supporting the Ongoing Development of Interventions in Gaucher Disease
    2021
    Summary Details
    OPEN
    Title: The Remote Assessment of Parkinsonism Supporting the Ongoing Development of Interventions in Gaucher Disease
    Author(s): Abigail Louise Higgins, Marco Toffoli, Stephen Mullin, Chiao‐Yin Lee, Sofia Koletsi, Micol Avenali, Fabio Blandini, Anthony HV. Schapira
    Journal Name: Neurodegenerative Disease Management
    Publisher: Informa UK Limited
    Vol: 11
    Issue #: 6
    Start Page: 451
    End Page: 458
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by
    DOI - Digital Object Identifier: 10.2217/nmt-2021-0032
    Best OA location URL: https://doi.org/10.2217/nmt-2021-0032
    Citation Count: 14
  • AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact
    2025
    Summary Details
    OPEN
    Title: AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact
    Author(s): Benjamin Scott Padman, Runa Lindblom, Michael Lazarou
    Journal Name: Journal of Cell Biology
    Publisher: Rockefeller University Press
    Vol: 224
    Issue #: 10
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1083/jcb.202411138
    Best OA location URL: https://doi.org/10.1083/jcb.202411138
    Citation Count: 0
  • Lysosome and Inflammatory Defects in GBA1‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition
    2020
    Summary Details
    OPEN
    Title: Lysosome and Inflammatory Defects in GBA1‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition
    Author(s): Anwesha Sanyal, Mark P. DeAndrade, Hailey S. Novis, Steven C. Lin, Jianjun Chang, Nathalie A. Lengacher, Julianna J. Tomlinson, Malú G. Tansey, Matthew J. LaVoie
    Journal Name: Movement Disorders
    Publisher: Wiley
    Vol: 35
    Issue #: 5
    Start Page: 760
    End Page: 773
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1002/mds.27994
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8167931
    Citation Count: 89
  • Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson’s disease on chromosome 7p15.3
    2017
    Summary Details
    OPEN
    Title: Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson’s disease on chromosome 7p15.3
    Author(s): Megha Murthy, Cornelis Blauwendraat, Sebastian Guelfi, John Hardy, Patrick A. Lewis, Daniah Trabzuni
    Journal Name: neurogenetics
    Publisher: Springer Science and Business Media LLC
    Vol: 18
    Issue #: 3
    Start Page: 121
    End Page: 133
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1007/s10048-017-0514-8
    Best OA location URL: https://link.springer.com/content/pdf/10.1007%2Fs10048-017-0514-8.pdf
    Citation Count: 70
  • Genetic analysis of FMR1 repeat expansion in essential tremor
    2015
    Summary Details
    OPEN
    Title: Genetic analysis of FMR1 repeat expansion in essential tremor
    Author(s): Lorraine N. Clark, X. Ye, X. Liu, Elan D. Louis
    Journal Name: Neuroscience Letters
    Publisher: Elsevier BV
    Vol: 593
    Issue #:
    Start Page: 114
    End Page: 117
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.neulet.2015.03.027
    Best OA location URL: http://doi.org/10.1016/j.neulet.2015.03.027
    Citation Count: 13
  • RedOx regulation of LRRK2 kinase activity by active site cysteines
    2024
    Summary Details
    OPEN
    Title: RedOx regulation of LRRK2 kinase activity by active site cysteines
    Author(s): Chiara R. Trilling, Jui-Hung Weng, Pallavi Kaila Sharma, Viktoria Nolte, Jian Wu, Wen Ma, Daniela Boassa, Susan S. Taylor, Friedrich W. Herberg
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 10
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41531-024-00683-5
    Best OA location URL: https://escholarship.org/uc/item/3qr8k4b2
    Citation Count: 6
  • Exosome/microvesicle content is altered in leucine‐rich repeat kinase 2 mutant induced pluripotent stem cell‐derived neural cells
    2019
    Summary Details
    RESTRICTED
    Title: Exosome/microvesicle content is altered in leucine‐rich repeat kinase 2 mutant induced pluripotent stem cell‐derived neural cells
    Author(s): Kate M. Candelario, Leonora Balaj, Tong Zheng, Johan Skog, Björn Scheffler, Xandra O. Breakefield, Birgitt Schüle, Dennis A. Steindler
    Journal Name: Journal of Comparative Neurology
    Publisher: Wiley
    Vol: 528
    Issue #: 7
    Start Page: 1203
    End Page: 1215
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1002/cne.24819
    Citation Count: 14
  • Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
    2017
    Summary Details
    OPEN
    Title: Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
    Author(s): Lilach Soreq, Jamie Rose, Eyal Soreq, John Hardy, Daniah Trabzuni, Mark Cookson, Colin Smith, Mina Ryten, Rickie Patani, Jernej Ule
    Journal Name: Cell Reports
    Publisher: Elsevier BV
    Vol: 18
    Issue #: 2
    Start Page: 557
    End Page: 570
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by
    DOI - Digital Object Identifier: 10.1016/j.celrep.2016.12.011
    Best OA location URL: http://www.cell.com/article/S2211124716316849/pdf
    Citation Count: 381
  • Music to move persons with Parkinson’s disease: a personalized approach
    2021
    Summary Details
    OPEN
    Title: Music to move persons with Parkinson’s disease: a personalized approach
    Author(s): Susanne Ten Holter, Jorik Nonnekes, Bastiaan R. Bloem
    Journal Name: Journal of Neurology
    Publisher: Springer Science and Business Media LLC
    Vol: 269
    Issue #: 1
    Start Page: 251
    End Page: 252
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1007/s00415-021-10615-5
    Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00415-021-10615-5.pdf
    Citation Count: 5
  • Sitagliptin elevates plasma and CSF incretin levels following oral administration to nonhuman primates: relevance for neurodegenerative disorders
    2024
    Summary Details
    OPEN
    Title: Sitagliptin elevates plasma and CSF incretin levels following oral administration to nonhuman primates: relevance for neurodegenerative disorders
    Author(s): Yazhou Li, Kelli L. Vaughan, Yun Wang, Seong‐Jin Yu, Eun-Kyung Bae, Ian A. Tamargo, Katherine O. Kopp, David Tweedie, Cheng‐Chuan Chiang, Keith T. Schmidt, Debomoy K. Lahiri, Michael A. Tones, Margaret M. Zaleska, Barry J. Hoffer, Julie A. Mattison, Nigel H. Greig
    Journal Name: GeroScience
    Publisher: Springer Science and Business Media LLC
    Vol: 46
    Issue #: 5
    Start Page: 4397
    End Page: 4414
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1007/s11357-024-01120-4
    Best OA location URL: https://link.springer.com/content/pdf/10.1007/s11357-024-01120-4.pdf
    Citation Count: 4
  • Exploration of Fluorinated Pyrazolidine‐3,5‐Diones for Positron Emission Tomography Imaging of the P2Y12 Receptor in the Central Nervous System
    2025
    Summary Details
    RESTRICTED
    Title: Exploration of Fluorinated Pyrazolidine‐3,5‐Diones for Positron Emission Tomography Imaging of the P2Y12 Receptor in the Central Nervous System
    Author(s): E. Johanna L. Stéen, A. Olivier, Berend van der Wildt, Pedro Pereira, Khaled Alkayal, Leopoldo J. Gabella Carena, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Barbara Zarzycka, Iwan J. P. de Esch, Albert D. Windhorst
    Journal Name: ChemMedChem
    Publisher: Wiley
    Vol: 20
    Issue #: 17
    Start Page: e202500483
    End Page: e202500483
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1002/cmdc.202500483
    Best OA location URL: https://research.vu.nl/en/publications/c82cecf0-3c70-439a-8c8f-03f948781d0b
    Citation Count: 0
  • Freezing of gait and levodopa
    2021
    Summary Details
    OPEN
    Title: Freezing of gait and levodopa
    Author(s): Moran Gilat, Nicholas D’Cruz, Pieter Ginis, Wim Vandenberghe, Alice Nieuwboer
    Journal Name: The Lancet Neurology
    Publisher: Elsevier BV
    Vol: 20
    Issue #: 7
    Start Page: 505
    End Page: 506
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/s1474-4422(21)00175-7
    Best OA location URL: http://www.thelancet.com/article/S1474442221001757/pdf
    Citation Count: 8
  • Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
    2018
    Summary Details
    OPEN
    Title: Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
    Author(s): Lana M. Chahine, Thomas G. Beach, Nicholas Seedorff, Chelsea Caspell‐Garcia, Christopher S. Coffey, Michael C. Brumm, Charles H. Adler, Geidy E. Serrano, Carly Linder, Sherri Mosovsky, Tatiana Foroud, Holly Riss, Dixie Ecklund, John Seibyl, Danna Jennings, Vanessa Arnedo, Lindsey Riley, Kuldip D. Dave, Brit Mollenhauer
    Journal Name: Journal of Parkinson’s Disease
    Publisher: SAGE Publications
    Vol: 8
    Issue #: 4
    Start Page: 517
    End Page: 527
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.3233/jpd-181434
    Best OA location URL: https://resolver.sub.uni-goettingen.de/purl?gro-2/137434
    Citation Count: 22
  • Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA
    2016
    Summary Details
    RESTRICTED
    Title: Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA
    Author(s): Suaad Abd-Elhadi, M. Basora, Dolores Vilas, Eduardo Tolosa, Ronit Sharon
    Journal Name: Analytical and Bioanalytical Chemistry
    Publisher: Springer Science and Business Media LLC
    Vol: 408
    Issue #: 27
    Start Page: 7669
    End Page: 7677
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1007/s00216-016-9863-7
    Citation Count: 24
  • Neurophysiological Correlates of Gait in the Human Basal Ganglia and the PPN Region in Parkinson’s Disease
    2020
    Summary Details
    OPEN
    Title: Neurophysiological Correlates of Gait in the Human Basal Ganglia and the PPN Region in Parkinson’s Disease
    Author(s): Rene Molina, Chris J. Hass, Kristen Sowalsky, Abigail C. Schmitt, Enrico Opri, Jaime A. Roper, Daniel Martinez‐Ramirez, Christopher W. Hess, Kelly D. Foote, Michael S. Okun, Aysegul Gunduz
    Journal Name: Frontiers in Human Neuroscience
    Publisher: Frontiers Media SA
    Vol: 14
    Issue #:
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.3389/fnhum.2020.00194
    Best OA location URL: https://www.frontiersin.org/articles/10.3389/fnhum.2020.00194/pdf
    Citation Count: 27
  • CSF biomarkers associated with disease heterogeneity in early Parkinson’s disease: the Parkinson’s Progression Markers Initiative study
    2016
    Summary Details
    OPEN
    Title: CSF biomarkers associated with disease heterogeneity in early Parkinson’s disease: the Parkinson’s Progression Markers Initiative study
    Author(s): The Parkinson’s Progression Marker Initiative, Ju Hee Kang, Brit Mollenhauer, Christopher S. Coffey, Jon B Toledo, Daniel Weintraub, Douglas R. Galasko, David J. Irwin, Vivianna Van Deerlin, Alice S Chen-Plotkin, Chelsea Caspell-Garcia, Teresa Waligorska, Peggy Taylor, Nirali Shah, Sarah Pan, Pawel Zero, Mark Frasier, Kenneth Marek, Karl Kieburtz, Danna Jennings, Caroline M Tanner, Tanya Simuni, Andrew Singleton, Arthur W. Toga, Sohini Chowdhury, John Q. Trojanowski, Leslie M. Shaw
    Journal Name: Acta Neuropathologica
    Publisher: Springer Science and Business Media LLC
    Vol: 131
    Issue #: 6
    Start Page: 935
    End Page: 949
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1007/s00401-016-1552-2
    Best OA location URL: https://resolver.sub.uni-goettingen.de/purl?gro-2/40503
    Citation Count: 212
  • Composite measures of motor performance and self-efficacy are better determinants of postural instability and gait difficulties than individual clinical measures in Parkinson's disease
    2022
    Summary Details
    OPEN
    Title: Composite measures of motor performance and self-efficacy are better determinants of postural instability and gait difficulties than individual clinical measures in Parkinson's disease
    Author(s): Chatkaew Pongmala, Stiven Roytman, Miriam van Emde Boas, Olivia Dickinson, Prabesh Kanel, Nicolaas I. Bohnen
    Journal Name: Parkinsonism & Related Disorders
    Publisher: Elsevier BV
    Vol: 107
    Issue #:
    Start Page: 105251
    End Page: 105251
    Publication Date:
    Open Access(OA) Status: OPEN
    License: other-oa
    DOI - Digital Object Identifier: 10.1016/j.parkreldis.2022.105251
    Best OA location URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10028594/pdf/nihms-1882881.pdf
    Citation Count: 4
  • Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns
    2021
    Summary Details
    OPEN
    Title: Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns
    Author(s): Shady Rahayel, Bratislav Miŝić, Ying‐Qiu Zheng, Zhen-Qi Liu, Alaa Abdelgawad, Nooshin Abbasi, Anna Caputo, Bin Zhang, Angela Lo, Victoria Kehm, Michael Kozak, Han Soo Yoo, Alain Dagher, Kelvin C. Luk
    Journal Name: Brain
    Publisher: Oxford University Press (OUP)
    Vol: 145
    Issue #: 5
    Start Page: 1743
    End Page: 1756
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1093/brain/awab440
    Best OA location URL: https://academic.oup.com/brain/article-pdf/145/5/1743/43948322/awab440.pdf
    Citation Count: 52
  • Functional ataxia in a specialized ataxia center
    2024
    Summary Details
    RESTRICTED
    Title: Functional ataxia in a specialized ataxia center
    Author(s): Luíza Alves Corazza, Augusto Bragança Reis Rosa, Thiago Yoshinaga Tonholo Silva, Flávio Moura Rezende Filho, Péricles Maranhão‐Filho, José Luiz Pedroso, Orlando Graziani Póvoas Barsottini, Alberto J. Espay
    Journal Name: Parkinsonism & Related Disorders
    Publisher: Elsevier BV
    Vol: 120
    Issue #:
    Start Page: 106006
    End Page: 106006
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1016/j.parkreldis.2024.106006
    Citation Count: 0
  • Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference
    2025
    Summary Details
    OPEN
    Title: Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference
    Author(s): Bess Frost, James B. Rowe, Rufus Akinyemi, Jose F. Abisambra, Nicholas J. Ashton, Matthias Brendel, Luc Buée, David Butler, María C. Carrillo, Peter S. Chung, Claire D. Clelland, Sarah L. DeVos, Kristophe Diaz, Rebecca M. Edelmayer, Fanny M. Elahi, Ratnavalli Ellajosyula, Colin Ewen, Igor C. Fontana, Marie‐Christine Galas, Oskar Hansson, Günter U. Höglinger, Kanta Horie, Agustín Ibáñez, Linde Jacobs, Mahmoud Bukar Maina, Maura Malpetti, Eric McDade, William A. McEwan, Laia Montoliu‐Gaya, Catherine J. Mummery, Miranda E. Orr, Jonathan D. Rohrer, Amy Rommel, Carlos Sastre, Tara L. Spires‐Jones, Boon Lead Tee, Tim J. Viney, Jamie M. Walker, Susanne Wegmann, Kristin R. Wildsmith, Ravi Yadav, Simin Mahinrad, Claire E. Sexton
    Journal Name: Alzheimer's & Dementia
    Publisher: Wiley
    Vol: 21
    Issue #: 5
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1002/alz.70078
    Best OA location URL: https://doi.org/10.1002/alz.70078
    Citation Count: 0
  • Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders
    2022
    Summary Details
    OPEN
    Title: Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders
    Author(s): Corinne Morfill, Stanislava Pankratova, Pedro Machado, Nathalie Fernando, Anna Regoutz, Federica Talamona, Alessandra Pinna, Michał M. Kłosowski, Robert J. Wilkinson, Roland A. Fleck, Fang Xie, Alexandra E. Porter, Darya Kiryushko
    Journal Name: ACS Applied Materials & Interfaces
    Publisher: American Chemical Society (ACS)
    Vol: 14
    Issue #: 42
    Start Page: 47445
    End Page: 47460
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by
    DOI - Digital Object Identifier: 10.1021/acsami.2c14220
    Best OA location URL: https://doi.org/10.1021/acsami.2c14220
    Citation Count: 18
  • P2RX7, an adaptive immune response gene, is associated with Parkinson's disease risk and age at onset
    2024
    Summary Details
    OPEN
    Title: P2RX7, an adaptive immune response gene, is associated with Parkinson's disease risk and age at onset
    Author(s): Shachar Shani, Mali Gana‐Weisz, Anat Bar‐Shira, Avner Thaler, Tanya Gurevich, Anat Mirelman, Nir Giladi, Roy N. Alcalay, Avi Orr‐Urtreger, Orly Goldstein
    Journal Name: Journal of Parkinson’s Disease
    Publisher: SAGE Publications
    Vol: 14
    Issue #: 8
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1177/1877718x241296015
    Best OA location URL: https://doi.org/10.1177/1877718x241296015
    Citation Count: 0
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