6251 - 6300 of 7939 Results
Title
Year
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OPENTitle: Computer keyboard interaction as an indicator of early Parkinson’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep34468Best OA location URL: https://doi.org/10.1038/srep34468Citation Count: 91
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RESTRICTEDTitle: AAV viral vector delivery to the brain by shape-conforming MR-guided infusionsJournal Name: Journal of Controlled ReleasePublisher: Elsevier BVVol: 240Issue #:Start Page: 434End Page: 442Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jconrel.2016.02.034Citation Count: 36
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RESTRICTEDTitle: Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbationsJournal Name: Brain ResearchPublisher: Elsevier BVVol: 1648Issue #:Start Page: 603End Page: 616Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1016/j.brainres.2016.02.033Best OA location URL: https://doi.org/10.1016/j.brainres.2016.02.033Citation Count: 39
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OPENTitle: Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrumJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 46Issue #:Start Page: 32End Page: 42Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2016.06.003Best OA location URL: https://europepmc.org/articles/pmc5018437?pdf=renderCitation Count: 22
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RESTRICTEDTitle: Gene therapy to target ER stress in brain diseasesJournal Name: Brain ResearchPublisher: Elsevier BVVol: 1648Issue #:Start Page: 561End Page: 570Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.brainres.2016.04.064Citation Count: 31
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RESTRICTEDTitle: Injury to the nervous system: A look into the ERJournal Name: Brain ResearchPublisher: Elsevier BVVol: 1648Issue #:Start Page: 617End Page: 625Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.brainres.2016.04.053Citation Count: 24
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RESTRICTEDTitle: LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectivesJournal Name: Clinical Pharmacology: Advances and ApplicationsPublisher: Informa UK LimitedVol: Volume 8Issue #:Start Page: 177End Page: 189Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-ncDOI - Digital Object Identifier: 10.2147/cpaa.s102191Best OA location URL: https://www.dovepress.com/getfile.php?fileID=33080Citation Count: 41
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OPENTitle: Perspective: Data sharing for discoveryJournal Name: NaturePublisher: Springer Science and Business Media LLCVol: 538Issue #: 7626Start Page: S4End Page: S4Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/538s4aBest OA location URL: https://www.nature.com/articles/538S4a.pdfCitation Count: 6
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RESTRICTEDTitle: The best medicine? The influence of physical activity and inactivity on Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 31Issue #: 10Start Page: 1444End Page: 1454Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.26728Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491025Citation Count: 97
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RESTRICTEDTitle: Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's diseaseJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 113Issue #:Start Page: 110End Page: 123Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2016.09.028Citation Count: 54
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OPENTitle: Cognitive impairment in Parkinson's disease: Association between patient-reported and clinically measured outcomesJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 33Issue #:Start Page: 107End Page: 114Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2016.09.025Best OA location URL: https://europepmc.org/articles/pmc5154808?pdf=renderCitation Count: 24
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OPENTitle: Integrative transcriptomic meta-analysis of Parkinson’s disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep34579Best OA location URL: https://www.nature.com/articles/srep34579.pdfCitation Count: 35
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OPENTitle: PREFACE: Divergent roles of ER stress in neurodegeneration and brain disordersJournal Name: Brain ResearchPublisher: Elsevier BVVol: 1648Issue #:Start Page: 527End Page: 529Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.brainres.2016.09.014Best OA location URL: http://manuscript.elsevier.com/S0006899316306229/pdf/S0006899316306229.pdfCitation Count: 1
- Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI2016RESTRICTEDTitle: Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRIJournal Name: Magnetic Resonance Materials in Physics, Biology and MedicinePublisher: Springer Science and Business Media LLCVol: 30Issue #: 2Start Page: 121End Page: 125Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s10334-016-0590-zCitation Count: 73
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OPENTitle: Ade novocompound targeting α-synuclein improves deficits in models of Parkinson’s diseaseJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 139Issue #: 12Start Page: 3217End Page: 3236Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/aww238Best OA location URL: https://academic.oup.com/brain/article-pdf/139/12/3217/24173157/aww238.pdfCitation Count: 120
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OPENTitle: SWATH-MS proteome profiling data comparison of DJ-1, Parkin, and PINK1 knockout rat striatal mitochondriaJournal Name: Data in BriefPublisher: Elsevier BVVol: 9Issue #:Start Page: 589End Page: 593Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.dib.2016.09.031Best OA location URL: https://doi.org/10.1016/j.dib.2016.09.031Citation Count: 12
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RESTRICTEDTitle: Immunomodulators as Therapeutic Agents in Mitigating the Progression of Parkinson’s DiseaseJournal Name: Brain SciencesPublisher: MDPI AGVol: 6Issue #: 4Start Page: 41End Page: 41Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-byDOI - Digital Object Identifier: 10.3390/brainsci6040041Best OA location URL: https://www.mdpi.com/2076-3425/6/4/41/pdf?version=1474633139Citation Count: 18
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OPENTitle: Self-Reported Symptoms of Parkinson’s Disease by Sex and Disease DurationJournal Name: Western Journal of Nursing ResearchPublisher: SAGE PublicationsVol: 39Issue #: 11Start Page: 1412End Page: 1428Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1177/0193945916670904Best OA location URL: https://europepmc.org/articles/pmc5505809?pdf=renderCitation Count: 13
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OPENTitle: Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson'sJournal Name: Annals of NeurologyPublisher: WileyVol: 80Issue #: 5Start Page: 674End Page: 685Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1002/ana.24781Best OA location URL: https://doi.org/10.1002/ana.24781Citation Count: 228
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OPENTitle: Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individualsJournal Name: European Journal of NeurosciencePublisher: WileyVol: 45Issue #: 10Start Page: 1241End Page: 1251Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/ejn.13408Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejn.13408Citation Count: 9
- Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism2016OPENTitle: Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropismJournal Name: Gene TherapyPublisher: Springer Science and Business Media LLCVol: 23Issue #: 11Start Page: 807End Page: 814Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/gt.2016.62Best OA location URL: https://www.nature.com/articles/gt201662.pdfCitation Count: 65
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OPENTitle: Ruminative brooding is associated with salience network coherence in early pubertal youthJournal Name: Social Cognitive and Affective NeurosciencePublisher: Oxford University Press (OUP)Vol: 12Issue #: 2Start Page: 298End Page: 310Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1093/scan/nsw133Best OA location URL: https://academic.oup.com/scan/article-pdf/12/2/298/27104291/nsw133.pdfCitation Count: 36
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RESTRICTEDTitle: Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISAJournal Name: Analytical and Bioanalytical ChemistryPublisher: Springer Science and Business Media LLCVol: 408Issue #: 27Start Page: 7669End Page: 7677Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s00216-016-9863-7Citation Count: 23
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OPENTitle: Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s DiseaseJournal Name: Cell Stem CellPublisher: Elsevier BVVol: 19Issue #: 6Start Page: 709End Page: 724Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.stem.2016.08.002Best OA location URL: https://europepmc.org/articles/pmc5135570?pdf=renderCitation Count: 404
- Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies2016OPENTitle: Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodiesJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 49Issue #:Start Page: 214.e13End Page: 214.e15Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2016.08.023Best OA location URL: https://europepmc.org/articles/pmc5154872?pdf=renderCitation Count: 14
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OPENTitle: Identification of small molecules that bind to the mitochondrial protein mitoNEETJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 26Issue #: 21Start Page: 5350End Page: 5353Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2016.09.009Best OA location URL: https://europepmc.org/articles/pmc5482219?pdf=renderCitation Count: 35
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OPENTitle: Structural insights into Parkin substrate lysine targeting from minimal Miro substratesJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep33019Best OA location URL: https://www.nature.com/articles/srep33019.pdfCitation Count: 49
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OPENTitle: Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodiesJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 3Issue #: 10Start Page: 769End Page: 780Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.337Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.337Citation Count: 54
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OPENTitle: No diurnal variation of classical and candidate biomarkers of Alzheimer’s disease in CSFJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 11Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13024-016-0130-3Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-016-0130-3Citation Count: 20
- Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease2016OPENTitle: Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's diseaseJournal Name: The FASEB JournalPublisher: WileyVol: 30Issue #: 12Start Page: 4141End Page: 4148Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1096/fj.201600816rBest OA location URL: https://www.fasebj.org/doi/pdf/10.1096/fj.201600816RCitation Count: 324
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OPENTitle: Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-Type Calcium Channel Blocker ML218 in MPTP-Treated MonkeysJournal Name: ACS Chemical NeurosciencePublisher: American Chemical Society (ACS)Vol: 7Issue #: 11Start Page: 1543End Page: 1551Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/acschemneuro.6b00186Best OA location URL: https://europepmc.org/articles/pmc5510653?pdf=renderCitation Count: 9
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OPENTitle: Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissueJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-016-0371-yBest OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-016-0371-yCitation Count: 65
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OPENTitle: Neuropsychiatric characteristics of GBA-associated Parkinson diseaseJournal Name: Journal of the Neurological SciencesPublisher: Elsevier BVVol: 370Issue #:Start Page: 63End Page: 69Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.jns.2016.08.059Best OA location URL: https://europepmc.org/articles/pmc5268078?pdf=renderCitation Count: 51
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RESTRICTEDTitle: Environmental Exposures and Parkinson’s DiseaseJournal Name: International Journal of Environmental Research and Public HealthPublisher: MDPI AGVol: 13Issue #: 9Start Page: 881End Page: 881Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-byDOI - Digital Object Identifier: 10.3390/ijerph13090881Best OA location URL: https://www.mdpi.com/1660-4601/13/9/881/pdf?version=1472899297Citation Count: 164
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OPENTitle: Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s DiseaseJournal Name: Journal of Alzheimer's DiseasePublisher: SAGE PublicationsVol: 54Issue #: 4Start Page: 1395End Page: 1408Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jad-160528Best OA location URL: https://europepmc.org/articles/pmc5074904?pdf=renderCitation Count: 49
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OPENTitle: Integration of transcriptomic and genomic data suggests candidate mechanisms for APOE4-mediated pathogenic action in Alzheimer’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep32583Best OA location URL: https://www.nature.com/articles/srep32583.pdfCitation Count: 20
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OPENTitle: Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson’s Disease and Control SubjectsJournal Name: Journal of Parkinson's DiseasePublisher: SAGE PublicationsVol: 6Issue #: 4Start Page: 761End Page: 770Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jpd-160888Best OA location URL: https://europepmc.org/articles/pmc5501392?pdf=renderCitation Count: 82
- Epidemiology of Major Neurodegenerative Diseases in Women: Contribution of the Nurses’ Health Study2016RESTRICTEDTitle: Epidemiology of Major Neurodegenerative Diseases in Women: Contribution of the Nurses’ Health StudyJournal Name: American Journal of Public HealthPublisher: American Public Health AssociationVol: 106Issue #: 9Start Page: 1650End Page: 1655Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.2105/ajph.2016.303324Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981803Citation Count: 21
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OPENTitle: Impaired perception of biological motion in Parkinson’s disease.Journal Name: NeuropsychologyPublisher: American Psychological Association (APA)Vol: 30Issue #: 6Start Page: 720End Page: 730Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific, author manuscriptDOI - Digital Object Identifier: 10.1037/neu0000276Best OA location URL: https://doi.org/10.1037/neu0000276Citation Count: 45
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RESTRICTEDTitle: Magnetic resonance imaging as a potential biomarker for Parkinson's diseaseJournal Name: Translational ResearchPublisher: Elsevier BVVol: 175Issue #:Start Page: 4End Page: 16Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.trsl.2015.12.006Citation Count: 23
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RESTRICTEDTitle: Sensory aspects in myasthenia gravis: A translational approachJournal Name: Journal of the Neurological SciencesPublisher: Elsevier BVVol: 368Issue #:Start Page: 379End Page: 388Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jns.2016.07.014Best OA location URL: http://repositorio.udes.edu.co/bitstreams/b124e51e-784c-4cf5-bff1-c42eb6dbb8fb/downloadCitation Count: 8
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OPENTitle: The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein NumbJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 93Issue #:Start Page: 1End Page: 11Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2016.03.022Best OA location URL: https://europepmc.org/articles/pmc4930744?pdf=renderCitation Count: 24
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RESTRICTEDTitle: Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's DiseasesJournal Name: Cold Spring Harbor Perspectives in BiologyPublisher: Cold Spring Harbor LaboratoryVol: 8Issue #: 11Start Page: a023630End Page: a023630Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1101/cshperspect.a023630Best OA location URL: http://cshperspectives.cshlp.org/content/8/11/a023630.full.pdfCitation Count: 102
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OPENTitle: Association ofGBAMutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson DiseaseJournal Name: JAMA NeurologyPublisher: American Medical Association (AMA)Vol: 73Issue #: 10Start Page: 1217End Page: 1217Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1001/jamaneurol.2016.2245Best OA location URL: https://jamanetwork.com/journals/jamaneurology/articlepdf/2546252/noi160057.pdfCitation Count: 197
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OPENTitle: Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II‐mediated respirationJournal Name: PROTEOMICS – Clinical ApplicationsPublisher: WileyVol: 10Issue #: 12Start Page: 1205End Page: 1217Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/prca.201600005Best OA location URL: https://europepmc.org/articles/pmc5810131?pdf=renderCitation Count: 29
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OPENTitle: Alpha‐synuclein RT‐QuIC in the CSF of patients with alpha‐synucleinopathiesJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 3Issue #: 10Start Page: 812End Page: 818Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1002/acn3.338Best OA location URL: https://doi.org/10.1002/acn3.338Citation Count: 417
- Large-Scale Wearable Sensor Deployment in Parkinson’s Patients: The Parkinson@Home Study Protocol2016OPENTitle: Large-Scale Wearable Sensor Deployment in Parkinson’s Patients: The Parkinson@Home Study ProtocolJournal Name: JMIR Research ProtocolsPublisher: JMIR Publications Inc.Vol: 5Issue #: 3Start Page: e172End Page: e172Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.2196/resprot.5990Best OA location URL: https://www.researchprotocols.org/2016/3/e172/PDFCitation Count: 63
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OPENTitle: Structural connectivity profile of scans without evidence of dopaminergic deficit (SWEDD) patients compared to normal controls and Parkinson’s disease patientsJournal Name: SpringerPlusPublisher: Springer Science and Business Media LLCVol: 5Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40064-016-3110-8Best OA location URL: https://springerplus.springeropen.com/track/pdf/10.1186/s40064-016-3110-8Citation Count: 10
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OPENTitle: Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug deliveryJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep31732Best OA location URL: https://www.nature.com/articles/srep31732.pdfCitation Count: 40
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OPENTitle: Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitorsJournal Name: eLifePublisher: eLife Sciences Publications, LtdVol: 5Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.7554/elife.17111Best OA location URL: https://doi.org/10.7554/elife.17111Citation Count: 50