4401 - 4450 of 8587 Results
Title
Year
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RESTRICTEDTitle: The Coalition Against Major Diseases: Dopamine Transporter Neuroimaging as an Enrichment Biomarker To Enable Parkinson's Disease Clinical Trials (P06.049)Journal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 80Issue #: 7_supplementStart Page:End Page:Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1212/wnl.80.7_supplement.p06.049Citation Count: 2
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OPENTitle: Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive ImmunoassayJournal Name: Frontiers in NeurosciencePublisher: Frontiers Media SAVol: 13Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnins.2019.00889Best OA location URL: https://doi.org/10.3389/fnins.2019.00889Citation Count: 43
- Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors2011RESTRICTEDTitle: Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitorsJournal Name: Pharmacological ResearchPublisher: Elsevier BVVol: 64Issue #: 3Start Page: 268End Page: 273Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.phrs.2011.03.017Citation Count: 52
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OPENTitle: Analysis of Heterozygous PRKN Variants and Copy‐Number Variations in Parkinson's DiseaseJournal Name: Movement DisordersPublisher: WileyVol: 36Issue #: 1Start Page: 178End Page: 187Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.28299Citation Count: 45
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OPENTitle: Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementiaJournal Name: American Journal of Physiology-Heart and Circulatory PhysiologyPublisher: American Physiological SocietyVol: 315Issue #: 2Start Page: H284End Page: H290Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1152/ajpheart.00206.2018Best OA location URL: https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00206.2018Citation Count: 12
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RESTRICTEDTitle: Chelerythrine promotes Ca2+-dependent calpain activation in neuronal cells in a PKC-independent mannerJournal Name: Biochimica et Biophysica Acta (BBA) - General SubjectsPublisher: Elsevier BVVol: 1861Issue #: 4Start Page: 922End Page: 935Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.bbagen.2017.01.021Citation Count: 18
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OPENTitle: Fidelity of frequency and phase entrainment of circuit-level spike activity during DBSJournal Name: Journal of NeurophysiologyPublisher: American Physiological SocietyVol: 114Issue #: 2Start Page: 825End Page: 834Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1152/jn.00259.2015Best OA location URL: http://doi.org/10.1152/jn.00259.2015Citation Count: 47
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RESTRICTEDTitle: Molecular rotors report on changes in live cell plasma membrane microviscosity upon interaction with beta-amyloid aggregatesJournal Name: Soft MatterPublisher: Royal Society of Chemistry (RSC)Vol: 14Issue #: 46Start Page: 9466End Page: 9474Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1039/c8sm01633jBest OA location URL: http://spiral.imperial.ac.uk/bitstream/10044/1/65822/2/manuscript_final%20plus%20methods.pdfCitation Count: 40
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OPENTitle: Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLBJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 115Issue #: 51Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1073/pnas.1813365115Best OA location URL: https://www.pnas.org/content/pnas/115/51/E12053.full.pdfCitation Count: 77
- TNF-α knockout and minocycline treatment attenuates blood–brain barrier leakage in MPTP-treated mice2007OPENTitle: TNF-α knockout and minocycline treatment attenuates blood–brain barrier leakage in MPTP-treated miceJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 26Issue #: 1Start Page: 36End Page: 46Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2006.11.012Best OA location URL: http://doi.org/10.1016/j.nbd.2006.11.012Citation Count: 166
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OPENTitle: A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium ChannelsJournal Name: ACS Chemical BiologyPublisher: American Chemical Society (ACS)Vol: 15Issue #: 9Start Page: 2539End Page: 2550Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/acschembio.0c00577Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7502546Citation Count: 17
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OPENTitle: Deep Brain Stimulation in a Case of Mitochondrial DiseaseJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 3Issue #: 2Start Page: 139End Page: 145Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mdc3.12241Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12241Citation Count: 9
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OPENTitle: Minimal Clinically Important Difference for UPDRS‐III in Daily PracticeJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 5Issue #: 4Start Page: 448End Page: 450Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mdc3.12632Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12632Citation Count: 46
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RESTRICTEDTitle: Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 40Issue #:Start Page: 83End Page: 84Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2017.05.001Citation Count: 7
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RESTRICTEDTitle: Disease-modifying therapies for Parkinson's diseaseJournal Name: The Biomedical & Life Sciences CollectionPublisher: Henry Stewart TalksVol: 2013Issue #: 3Start Page:End Page:Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.69645/krxj9755Citation Count: 0
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OPENTitle: Comparison of two protocols for the generation of iPSC-derived human astrocytesJournal Name: Biological Procedures OnlinePublisher: Springer Science and Business Media LLCVol: 25Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12575-023-00218-xBest OA location URL: https://biologicalproceduresonline.biomedcentral.com/counter/pdf/10.1186/s12575-023-00218-xCitation Count: 6
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OPENTitle: Identification and In Vitro and In Vivo Characterization of KAC-50.1 as a Potential α-Synuclein PET RadioligandJournal Name: ACS Chemical NeurosciencePublisher: American Chemical Society (ACS)Vol: 15Issue #: 22Start Page: 4210End Page: 4219Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1021/acschemneuro.4c00493Best OA location URL: https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.4c00493Citation Count: 1
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OPENTitle: Effects of prolonged selective serotonin reuptake inhibition on the development and expression of l-DOPA-induced dyskinesia in hemi-parkinsonian ratsJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 77Issue #:Start Page: 1End Page: 8Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2013.09.017Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3865178Citation Count: 63
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OPENTitle: Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: Time course of protection and neurorestorationJournal Name: Brain ResearchPublisher: Elsevier BVVol: 1370Issue #:Start Page: 80End Page: 88Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.brainres.2010.11.006Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3019295Citation Count: 41
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RESTRICTEDTitle: Discordance Between Balance Ability and Perception Is Associated With Falls in Parkinson’s Disease: A Coordinated AnalysisJournal Name: Neurorehabilitation and Neural RepairPublisher: SAGE PublicationsVol: 39Issue #: 2Start Page:End Page:Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1177/15459683241300456Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/11850210Citation Count: 2
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OPENTitle: Soluble urokinase-type plasminogen activator receptor (suPAR) is elevated in caregivers of patients with parkinsonismJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 101Issue #:Start Page: 39End Page: 42Publication Date:Open Access(OA) Status: OPENLicense: other-oaDOI - Digital Object Identifier: 10.1016/j.parkreldis.2022.06.019Best OA location URL: https://doi.org/10.1016/j.parkreldis.2022.06.019Citation Count: 1
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OPENTitle: Protocol to measure centrosome cohesion deficits mediated by pathogenic LRRK2 in cultured cells using confocal microscopyJournal Name: STAR ProtocolsPublisher: Elsevier BVVol: 4Issue #: 1Start Page: 102024End Page: 102024Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.xpro.2022.102024Best OA location URL: https://doi.org/10.1016/j.xpro.2022.102024Citation Count: 6
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RESTRICTEDTitle: End of life planning in parkinsonian diseasesJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 62Issue #:Start Page: 73End Page: 78Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2019.01.026Citation Count: 9
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RESTRICTEDTitle: The meaning of a “hippo” response on the Montreal Cognitive Assessment in Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 19Issue #: 4Start Page: 463End Page: 465Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2012.09.005Citation Count: 1
- Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease2020RESTRICTEDTitle: Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's diseaseJournal Name: Journal of the Neurological SciencesPublisher: Elsevier BVVol: 418Issue #:Start Page: 117157End Page: 117157Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jns.2020.117157Citation Count: 16
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OPENTitle: Comprehensive subtyping of Parkinson’s disease patients with similarity fusion: a case study with BioFIND dataJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-021-00228-0Best OA location URL: https://escholarship.org/uc/item/4gf4057zCitation Count: 17
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RESTRICTEDTitle: The Hypoxia Response Pathway: A Potential Intervention Target in Parkinson's Disease?Journal Name: Movement DisordersPublisher: WileyVol: 39Issue #: 2Start Page: 273End Page: 293Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.29688Citation Count: 8
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OPENTitle: The Discovery of Central Nervous System Lymphatic Vessels: The Missing Link That Closes the Circle of Brain ImmunosurveillanceJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 3Issue #: 1Start Page: 29End Page: 30Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mdc3.12282Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12282Citation Count: 1
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OPENTitle: Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson miceJournal Name: JCI InsightPublisher: American Society for Clinical InvestigationVol: 10Issue #: 13Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1172/jci.insight.188413Best OA location URL: http://insight.jci.org/articles/view/188413/files/pdfCitation Count: 0
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OPENTitle: Probing the striatal dopamine system for a putative neuroprotective effect of deep brain stimulation in Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 33Issue #: 4Start Page: 652End Page: 654Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27280Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5988253Citation Count: 8
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OPENTitle: Levodopa-responsive progressive encephalomyelitis with rigidity and myoclonus associated with glycine receptor antibodiesJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 82Issue #:Start Page: 7End Page: 9Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2020.11.008Best OA location URL: http://www.prd-journal.com/article/S1353802020308592/pdfCitation Count: 5
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RESTRICTEDTitle: Biomarkers for Parkinson’s DiseaseJournal Name: Science Translational MedicinePublisher: American Association for the Advancement of Science (AAAS)Vol: 3Issue #: 79Start Page:End Page:Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1126/scitranslmed.3002488Citation Count: 42
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OPENTitle: Diversity of dynamic voltage patterns in neuronal dendrites revealed by nanopipette electrophysiologyJournal Name: NanoscalePublisher: Royal Society of Chemistry (RSC)Vol: 15Issue #: 29Start Page: 12245End Page: 12254Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1039/d2nr03475aBest OA location URL: https://pubs.rsc.org/en/content/articlepdf/2023/nr/d2nr03475aCitation Count: 1
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RESTRICTEDTitle: Acute readmission following deep brain stimulation surgery for Parkinson's disease: A nationwide analysisJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 70Issue #:Start Page: 96End Page: 102Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2019.11.023Citation Count: 8
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OPENTitle: Detecting the symptoms of Parkinson’s disease with non-standard videoJournal Name: Journal of NeuroEngineering and RehabilitationPublisher: Springer Science and Business Media LLCVol: 21Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12984-024-01362-5Best OA location URL: https://link.springer.com/content/pdf/10.1186/s12984-024-01362-5.pdfCitation Count: 1
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OPENTitle: Sorting (Nexin-13) out Novel Insights into Endolysosomal Cholesterol ExportJournal Name: ContactPublisher: SAGE PublicationsVol: 5Issue #:Start Page: 251525642211145End Page: 251525642211145Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1177/25152564221114513Best OA location URL: https://journals.sagepub.com/doi/pdf/10.1177/25152564221114513Citation Count: 2
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OPENTitle: powerEQTL: an R package and shiny application for sample size and power calculation of bulk tissue and single-cell eQTL analysisJournal Name: BioinformaticsPublisher: Oxford University Press (OUP)Vol: 37Issue #: 22Start Page: 4269End Page: 4271Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1093/bioinformatics/btab385Best OA location URL: http://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btab385/38621070/btab385.pdfCitation Count: 26
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OPENTitle: APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson’s diseaseJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-022-00411-xBest OA location URL: https://www.nature.com/articles/s41531-022-00411-x.pdfCitation Count: 9
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RESTRICTEDTitle: Detection of Proteolytic Signatures for Parkinson's DiseaseJournal Name: Future NeurologyPublisher: Informa UK LimitedVol: 11Issue #: 1Start Page: 15End Page: 32Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.2217/fnl.16.3Citation Count: 0
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OPENTitle: Increased odds of bladder and bowel symptoms in early Parkinson's diseaseJournal Name: Neurourology and UrodynamicsPublisher: WileyVol: 37Issue #: 4Start Page: 1344End Page: 1348Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/nau.23443Citation Count: 10
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RESTRICTEDTitle: A late-onset neurological disorder: is progression inevitable?Journal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 108Issue #:Start Page: 105092End Page: 105092Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2022.06.014Citation Count: 0
- Enhanced arm swing improves Parkinsonian gait with EEG power modulations resembling healthy gait2021OPENTitle: Enhanced arm swing improves Parkinsonian gait with EEG power modulations resembling healthy gaitJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 91Issue #:Start Page: 96End Page: 101Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.parkreldis.2021.09.011Best OA location URL: https://doi.org/10.1016/j.parkreldis.2021.09.011Citation Count: 17
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RESTRICTEDTitle: Normal and pathological neuronal distribution of the human mesencephalic locomotor regionJournal Name: Movement DisordersPublisher: WileyVol: 34Issue #: 2Start Page: 218End Page: 227Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.27578Citation Count: 35
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OPENTitle: Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synucleinJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 89Issue #:Start Page: 41End Page: 47Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2021.06.010Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8429263Citation Count: 16
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OPENTitle: Biochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic ProfilesJournal Name: Journal of Proteome ResearchPublisher: American Chemical Society (ACS)Vol: 17Issue #: 7Start Page: 2460End Page: 2469Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/acs.jproteome.8b00224Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6599609Citation Count: 67
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RESTRICTEDTitle: Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson’s diseaseJournal Name: Clinical Autonomic ResearchPublisher: Springer Science and Business Media LLCVol: 29Issue #: 6Start Page: 603End Page: 614Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s10286-019-00632-wBest OA location URL: https://escholarship.org/content/qt5zh861v7/qt5zh861v7.pdf?t=qa7xspCitation Count: 16
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RESTRICTEDTitle: Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liabilityJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 28Issue #: 15Start Page: 2641End Page: 2646Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2018.06.034Best OA location URL: https://doi.org/10.7270/q2dr2z5hCitation Count: 13
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OPENTitle: Epidural Spinal Cord Stimulation Improves Motor Function in Rats With Chemically Induced ParkinsonismJournal Name: Neurorehabilitation and Neural RepairPublisher: SAGE PublicationsVol: 33Issue #: 12Start Page: 1029End Page: 1039Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1177/1545968319876891Best OA location URL: https://journals.sagepub.com/doi/pdf/10.1177/1545968319876891Citation Count: 11
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OPENTitle: Developing better digital health measures of Parkinson’s disease using free living data and a crowdsourced data analysis challengeJournal Name: PLOS Digital HealthPublisher: Public Library of Science (PLoS)Vol: 2Issue #: 3Start Page: e0000208End Page: e0000208Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pdig.0000208Best OA location URL: https://journals.plos.org/digitalhealth/article/file?id=10.1371/journal.pdig.0000208&type=printableCitation Count: 5
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OPENTitle: Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson’s diseaseJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 17Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13024-022-00554-8Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-022-00554-8Citation Count: 25