The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Access to Data and Biospecimens, 201514-3-3 Phosphorylation as a Biomarker of Parkinson’s Disease Supplement
Study Rationale:
Disruption of 14-3-3s protein is implicated in Parkinson’s disease (PD). Recently, we observed that 14-3-3 phosphorylation — a chemical modification of 14-3-3s — is... -
Target Validation, 2015Anti-inflammatory Role of Activin-A in Protection against Alpha-synuclein-mediated Pathology
Objective/Rationale:
Neuroinflammation is essential for the pathogenesis and progressionof Parkinson’s disease (PD); therefore, the identification of immunosuppressive agents that can... -
Target Advancement Program, 2016Biochemical Analysis and Structural Determination of LRRK2 with Kinase Inhibitors
Study Rationale:
Although pharmacological and surgical treatments are available to manage the symptoms of Parkinson’s disease (PD), none yet can slow down or stop the course of the... -
Improved Biomarkers and Clinical Outcome Measures, 2015Eye Tracking as a Biomarker for Manifest and Prodromal Parkinson’s Disease
Study Rationale:
Over the past 14 years, we have utilized sophisticated commercial eye movement monitoring equipment to collect data from over 3300 participants. Our work aims to... -
Improved Biomarkers and Clinical Outcome Measures, 2016Developing a Molecular Imaging Tool That Binds to Alpha-Synuclein and Inhibits Its Formation
Study Rationale:
Amyloid fibrils play a key role in Parkinson's disease (PD). Studying their formation from self‐assembled aggregates (protein clumps) would help aid the development of a valuable... -
Target Advancement Program, 2016Alpha-Synuclein Aggregates as an Inducer of Glial Senescence: Potential Role in Parkinson's Disease
Study Rationale:
Cellular senescence (deterioration) is a critical factor of biological aging that occurs in almost all peripheral tissues but little is known about its...
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Our funding programs support basic, translational and clinical research from academia and industry.