The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Spring 2022 RFA: Target Advancement Program - Target Validation, 2022Examining the Action of Potassium Channels and the Inflammasome in a Signaling Axis That Can Serve as a Pharmacological Target Against Parkinson’s Disease
Study Rationale: Both voltage-gated potassium channels and inflammatory signaling are known to be involved in Parkinson’s disease (PD). Each of these signaling systems contributes to the brain...
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Expanding Biological Understanding of PD, 2022Identifying Genes that Enhance the Activity of Glucocerebrosidase
Study Rationale: Parkinson’s disease (PD) causes uncontrollable trembling, progressive rigidity of muscles and an inability to walk. We do not yet understand why certain people are more prone than...
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Research Grant, 2022Development of Irreversible PET Radiotracers for Glucocerebrosidase
Study Rationale: Glucocerebrosidase (GBA) is an enzyme that removes a sugar that is attached to certain fat molecules in the healthy brain. This critical biochemical process begins to malfunction...
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Spring 2022 RFA: Target Advancement Program - Target Validation, 2022Production of Preclinical Model of REM Sleep Behavior Disorder Using Alpha-synuclein Fibrils
Study Rationale: REM sleep behavior disorder (RBD) is characterized by abnormal motor behaviors during the REM phase of sleep and is highly predictive of Parkinson’s disease (PD). A brain region...
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Therapeutic Pipeline Program, 2022Developing Selective Ion Channel Blockers that Reduce Neuroinflammation in Parkinson’s Disease
Study Rationale: We are developing novel therapeutics to reduce brain inflammation and enhance the survival and function of brain cells in Parkinson’s disease (PD). Studies over the past decade have...
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Spring 2022 RFP: Expanding Biological Understanding of Parkinson's Disease, 2022Assessing Genetic Predisposition to Gastrointestinal Symptoms in Young-onset and Late-onset Parkinson’s Disease
Study Rationale: Constipation is a common, nonmotor manifestation of Parkinson’s disease (PD) that can impact the quality of life of people with the condition. Yet little is known about the genetic...
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Our funding programs support basic, translational and clinical research from academia and industry.