The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2008Identification of binding proteins for alpha-synuclein oligomers in brain and cells
Mutations in the PARK-1 and PARK-4 genes leads to alpha-synuclein aggregation with pathology eventually resembling that of sporadic PD. One question is whether the insoluble form of alpha-synuclein is...
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Biomarkers, 2005Epigenetic Regulation of the alpha-synuclein Gene as a Biomarker of Susceptibility to PD
Available genetic information in Parkinson's disease does not account for all phenomena in the clinical expressivity of the disease. For example, in the Contursi kindred with the A53T substitution in...
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Biomarkers, 2005Biomarkers in Human Cerebrospinal Fluid
This proposal involves confirmatory as well as discovery-type proteomic analyses of protein profiles in the human cerebral spinal fluid (CSF) obtained from patients with Parkinson's disease (PD) at...
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Development of Progressive Pre-clinical Models of PD, 2006Generation of Transgenic Mice with Selective and Progressive Loss of Nigrostriatal Dopaminergic Neurons
Mutations in the alpha-synuclein gene are responsible for rare, dominantly inherited forms of familial Parkinson's disease, designated PARK1 and PARK4. Furthermore, alpha-synuclein is also the major...
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Development of Progressive Pre-clinical Models of PD, 2006P1 Artificial Chromosome Transgenic Mice as models for Progressive Parkinson Disease
Although most cases of Parkinson's disease occur without a family history, there are examples of highly hereditary forms of the disease. One rare form of hereditary PD is caused by alterations in a...
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Development of Progressive Pre-clinical Models of PD, 2006LRRK2 and PD Genetic Pre-clinical Models
The cause of Parkinson's in most patients is unknown, but in a small percentage of cases (three to five percent), mutation in a specific gene is causal. Several genes have been conclusively linked to...
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Our funding programs support basic, translational and clinical research from academia and industry.