Funded Studies

Study Rationale:

LRRK2 is a protein kinase that appears to be a key driver of some forms of Parkinson's disease (PD). Several potent, selective, brain-penetrant LRRK2 kinase inhibitors have been...

Study Rationale:
LRRK2 interacts with over 60 proteins and alters several molecular pathways, including autophagy (cell break down), mitochondria (powerhouses of the cell), neurites (cellular...

Study Rationale:
Mitochondria, cellular power plants, malfunction in Parkinson's disease (PD) and with advanced age. Aging and PD cause changes in communication between mitochondria and the rest of...

Hypothesis:
We hypothesize that the inflammatory protein galectin-3 contributes to PD progression.

Study Design:
We will use pre-clinical models that lack galectin-3 to evaluate inflammation, neuronal...

Study rationale:
Advances in our understanding of the genetics of Parkinson's disease (PD) have led to the generation of an array of pre-clinical models that mimic various hallmarks of the disease...

Study Rationale:
Epigenetic processes (changes in gene expression), such as DNA methylation (mechanism that cells use to control gene expression), ensure proper functioning of genetic materials in...