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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

  • Ohio

Filter Results (18)

  • Non-pharmacological Interventions for Gait and Balance, 2019
    Use of a Robotic Walking Device to Improve Home and Community Mobility in People with Parkinson's Disease

    Study Rationale:
    People with Parkinson's disease can have walking issues that prevent them from completing daily activities in and outside of their homes. This study uses a light, wearable robotic...

  • GBA Biology and Therapies, 2018
    GBA Defects Cause C5a-C5aR1-induced Neurodegeneration in Parkinson’s Disease

    Study Rationale:
    People with GBA-associated Parkinson’s disease (PD) lack enzymes that break down certain fatty molecules (e.g., glucosylceramide), preventing their cells from shedding these waste...

  • Target Advancement Program, 2017
    Farnesoid X Receptor to Reduce Neuroinflammation

    Study Rationale:
    Although the precise mechanism(s) for neurodegeneration in Parkinson's disease (PD) is unknown, evidence suggests that neuroinflammation is an important contributor. In this study, we...

  • Target Advancement Program, 2016
    Farnesoid X Receptor as a Target to Reduce Meuroinflammation

    Study Rationale:
    Although the precise mechanism(s) of neurodegeneration in Parkinson's disease (PD) are unknown, evidence suggests that neuroinflammation is an important contributor. In this study, we...

  • Target Advancement Program, 2016
    Targeting the Mitochondrial Unfolded Protein Response in Alpha-synuclein-induced Parkinson's Disease

    Study Rationale:
    The mitochondrial (powerhouse of the cell) unfolded protein response (mtUPR) is the first defense mechanism for maintaining proper quality of proteins within the mitochondria. Defects...

  • Rapid Response Innovation Awards, 2014
    Effect of Dietary Ketosis On Alpha-Synuclein Accumulation

    Study Rationale:
    A key feature of Parkinson’s disease is abnormal accumulation of the protein alpha-synuclein. Production of organic compounds called ketones is a normal metabolic process that occurs...

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