The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Priority Biology, 2021Gene Expression Changes Induced by Alpha-Synuclein
Study Rationale:
Deposits of the alpha-synuclein protein are the key cellular pathology recognized to drive the progression of Parkinson’s disease leading to the death of neurons. The alpha-synuclein... -
Research Grant Supplement, 2021Profiling the Removal of Damaged Mitochondria in Stem Cell-Derived Brain Cells from People with Parkinson’s
Promising Outcomes of Original Grant:
Our previous work has shown that metabolic failure plays a critical role in the pathology of Parkinson’s disease (PD). A plethora of evidence from different... -
Biosample Use Program, 2021Evaluating Neurotoxic Metabolites as Biomarkers of Parkinson’s Progression
Study Rationale:
Individuals with Parkinson’s disease (PD) show elevated markers of inflammation in their brains, cerebrospinal fluid and blood. We think that inflammation drives the worsening of... -
Therapeutic Pipeline Program, 2021Directed Evolution of Tailor-Made Molecular Chaperones
Study Rationale:
For cells to operate properly, the proteins they produce must fold properly and maintain the correct three-dimensional structure. This process relies on a special class of proteins... -
Research Grant, 2021A New Target for Limiting the Spread of Toxic Alpha-Synuclein Aggregation and Preventing Neuronal Degeneration
Study Rationale:
The pathological hallmark of Parkinson’s disease (PD) is the widespread accumulation of cellular inclusions, called Lewy Bodies, composed of clumps of improperly folded alpha... -
Access to Data and Biospecimens, 2021Assessing Inhibition of a Protein of the “Complement System” to Reduce Brain Inflammation and Neuronal Loss in People with Parkinson’s Disease
Study Rationale:
Inflammation contributes to the degeneration of neurons in the brains of people with Parkinson’s disease (PD). One of the molecules involved in this inflammatory...
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Our funding programs support basic, translational and clinical research from academia and industry.