Funded Studies

We intend to develop lines of clonal, stable and self-renewing human dopamine-producing neuronal progenitor cells. These will be derived from the part of the midbrain that gives rise to dopamine...

Study Rationale: Proteasomes are cylinder-like structures inside cells that breakdown unnecessary or damaged proteins. When proteasomes do not work properly, the unwanted proteins may accumulate and...

Study Rationale: Parkinson’s disease is often diagnosed using tests that require spinal fluid, which is collected through an invasive procedure called a lumbar puncture. However, this method can be...

Study Rationale: Parkinson’s disease (PD) is caused by the loss of neurons in the brain due to their inability to remove damaged and dysfunctional mitochondria. PINK1 kinase located on mitochondria is...

Study Rationale: Parkinson’s disease (PD) worsens over time, partly due to the spread of a harmful protein called α-synuclein between brain cells. This protein also triggers inflammation, which...

Study Rationale: Parkinson’s disease is caused by the accumulation of misfolded alpha-synuclein, a protein that spreads in the brain and nervous system. Current cerebrospinal fluid (CSF) tests require...