The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Development of OT-1xx2, a Novel Small Molecule TrkB Activator, for the Treatment of Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) poses a huge disease burden to patients and their families. Current approved therapies are largely focused on symptom relief and have little impact on the...
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Neuronal Synuclein Disease Endotypes 2024, 2025BIOLOGY IS THE DISEASE: Identifying Biological Endophenotypes Based on Alpha-synuclein and AD Pathology Profiles and Evaluate NSD-ISS Stage 3-6
Study Rationale: In the era where we aim to define diseases by biology and modifying treatment options become available for neurodegenerative diseases, the clinicopathological heterogeneity in alpha...
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Research Grant, 2025Fostering Knowledge of Gait in PD Through a Multifaceted Dissemination Approach
Study Rationale: Gait abnormalities are among the most debilitating symptoms of PD, associated with falls, reduced mobility and increased dependency. However, education on gait in PD and developments...
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Accelerating Biological Understanding and Therapeutic Translation for PD- Biology, 2025Role of TFEB Pathway Activators and ISR Inhibitors on Alpha-synuclein Associated Impaired Mitophagy in the a Pre-clinical Model Brain
Study Rationale: Accumulation of faulty mitochondria (the energy generators of our cells) is thought a be a cause of Parkinson’s disease. Therefore, if we could enhance removal and recycling of these...
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Accelerating Biological Understanding and Therapeutic Translation for PD- Biology, 2025Investigating the Interplay Between Mitochondrial DNA-containing VDIMs (vesicles derived from inner mitochondrial membrane) and LRRK2-dependent Lysosomal Defects in Parkinson’s Disease
Study Rationale: Mitochondria-the powerhouses of the cell, contain their own DNA (mtDNA), which when damaged, can cause defects in mitochondrial function. Mitochondria can package mtDNA by into small...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biomarkers, 2025An International Working Group for the Evaluation of Mitochondrial DNA as a PD Biomarker
Study Rationale: Changes to mitochondria (a compartment of cells important for providing energy) occur in some types of genetic (inherited) PD and PD that arises later in life with no known cause...
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Our funding programs support basic, translational and clinical research from academia and industry.