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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • T2T Validation - Endolysosomal Targets, 2026
    Toward an Atlas of Endolysosomal System Dysfunction with PD-associated Channels/Transporters

    Study Rationale:                   

    TMEM175 and ATP13A2 have been identified as risk genes for Parkinson’s disease. These proteins function to transport protons and polyamines through the lysosomal...

  • Fall 2025 RFP: Data Advice To Action, 2026
    Multi-resolution Pathway-centric Biomarker Discovery for Parkinson’s Disease Diagnosis, Prognosis, Progression, and Treatment Recommendations

    Study Rationale:                   

    Parkinson’s disease (PD) is difficult to diagnose early and to distinguish from related synucleinopathies such as DLB and MSA. Although single-nucleus RNA sequencing...

  • Research Grant, 2026
    Deep Mutational Scanning of TMEM175

    Study Rationale:                   

    Parkinson’s disease develops through a combination of ageing, environmental factors, and genetic risk. One gene linked to Parkinson’s is TMEM175, which encodes an...

  • Research Grant, 2026
    Cell Type Meta-eQTL Study in Human Brains

    Study Rationale:                                                

    Parkinson’s (PD) genome-wide association study (GWAS) with ~1.5 million subjects identified 90 PD risk signals with ~7,000 non-coding PD...

  • Research Grant, 2026
    Genetically Encoded Fluorescent Biosensors for Live-cell, Subcellular Detection of Distinct α-synuclein Aggregation States

    Study Rationale:                   

    Alpha-synuclein (aSYN) is a critical protein in health and Parkinson’s disease (PD). aSYN has a soluble form and a series of increasingly aggregated forms. These...

  • Research Grant, 2026
    Validation of ADx LRRK2 and pS1292 LRRK2 SiMOA Assays Using Standardized Sample Set

    Study Rationale:                   

    The goal of this project is to use standardized and validated samples to determine if the LRRK2 and pS1292 LRRK2 assays available through ADx Neurosciences can...

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