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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutics Development Initiative, 2011
    Dopamine D1 Positive Modulators for the Treatment of Parkinson's Disease

    Objective/Rationale:
    L-DOPA is the standard treatment of Parkinson’s disease (PD) but prolonged use results in dyskinesia. D2 agonists often require L-DOPA supplementation and can cause side effects...

  • Rapid Response Innovation Awards, 2011
    Alpha-synuclein and Tau Mislocalization to Dendritic Spines

    Objective/Rationale:
    In addition to motor disorders, Parkinson disease (PD) patients also suffer from cognitive deficits, which are believed to result from abnormal accumulation of alpha-synuclein, a...

  • Resource: Utilizing DATATOP Biospecimens, 2011
    Identification and Validation of Blood-borne Autoantibody Biomarkers for Parkinson's Disease

    Objective/Rationale:
    We recently discovered that self-reactive antibodies (autoantibodies) are abundant in blood and that detection of certain types of autoantibodies reveals the presence of disease...

  • LRRK2, 2011
    Impact of LRRK2 Kinase Activity on Synaptic Vesicle Trafficking

    Objective/Rationale:
    The presynaptic alteration seen in several LRRK2 disease model suggest that LRRK2 might influence synaptic function through effects on presynaptic proteins. The common G2019S...

  • Biomarkers, 2011
    GSTpi as a Blood Based Biomarker for Parkinson's Disease

    Objective/Rationale:
    The goal of this research project is to develop and validate a blood test that would identify individuals at risk for developing Parkinson’s disease and at a point in time prior...

  • MJFF Research Grant, 2011
    Multi-tracer positron emission tomography (PET) functional imaging as a tool to assess the relevance of rodent LRRK2 models to the human neurochemical phenotype associated with LRRK2 mutations related Parkinsonism

    Promising Outcomes of Original Grant:
    The goals of the original grant were to develop PET (a non invasive imaging technique used in the study of human Parkinson’s disease ) –derived measures of...

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Our funding programs support basic, translational and clinical research from academia and industry.

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