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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2020
    Revisiting Alpha-synuclein Pathology Staging and Detection Using an Expanded Antibodies Toolset

    Study Rationale:
    The levels of alpha-synuclein aggregates and their spreading to different brain region seem to correlate with Parkinson’s disease (PD) progression and symptoms. Increasing evidence...

  • Priority Biology, 2020
    Structural Insights into Activated Intermediates of Parkin Continued

    Study Rationale:
    Loss of proteins responsible for removing damaged mitochondria (the cell power plants) is the most common cause of young-onset Parkinson’s disease (YOPD). Parkin and PINK1 are key...

  • Research Grant, 2020
    Molecular Basis of Neurodegeneration in GBA-associated Parkinson’s Disease

    Study Rationale:
    Studies in human genetics have implicated the malfunction of a cellular compartment called the lysosome in the pathogenesis of Parkinson’s and other brain diseases. Lysosomes are...

  • Research Grant, 2021
    Genotyping of Lymphoblastoid Cell Lines from Familial and Sporadic Parkinson’s Disease

    Study Rationale:
    Our previous studies show deficits in a cell activity called centrosome cohesion in cells from people with Parkinson’s disease (PD) and a LRRK2 mutation. These deficits are reverted...

  • Biosample Use Program, 2020
    Identification of Autoantibodies in People at Risk of Developing Parkinson’s Disease Using Microarrays

    Study Rationale:    
    Autoantibodies are antibodies that mistakenly target and react with a person's own tissues or organs. Autoantibodies can be detected many years before symptoms develop in many...

  • Therapeutic Pipeline Program, 2020
    Novel Candidate against Alpha-synuclein for the Treatment of Parkinson’s Disease

    Study Rationale:
    The goal of this program is to develop a novel drug for Parkinson’s disease with a unique mechanism of action. We have a drug candidate that shows potential as an inhibitor of alpha...

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