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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2010
    Coordinated Reset (CR) Stimulation of the Subthalamic Nucleus

    Objective/Rationale: 
    Coordinated Reset (CR) stimulation improved locomotor activity in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP)-treated pre-clinical model in a “proof of concept” study...

  • MJFF Research Grant, 2010
    Establishing an LRRK2 Signaling Pathway and Assays for Patient Derived Samples

    Objective/Rationale: 
    Inherited mutations in a gene called LRRK2 have been found to cause Parkinson ’s disease. The LRRK2 gene encodes an enzyme called a kinase, for which no exact function has been...

  • MJFF Research Grant, 2010
    Development of an Assay to Detect LRRK2 Protein in Biological Samples

    Objective/Rationale: 
    LRRK2 (Leucine-Rich Repeat Kinase 2) is a protein thought to be involved in regulating signaling pathways in cells. Mutations in the gene for LRRK2 are associated with some...

  • MJFF Research Grant, 2010
    Intranasal GDNF for Parkinson's Disease: Next Steps in Preclinical Development

    Objective/Rationale: 
    GDNF, a “growth factor” capable of promoting the survival of dopamine neurons, has great potential as a treatment for Parkinson’s disease. However, getting GDNF into the brain has...

  • LRRK2, 2010
    The Trondheim LRRK2 Cohort Program

    Objective/Rationale: 
    We are examining a Symptoms & Side Effects family members of LRRK2-PD patients looking for clinical features indicating differences between mutation carriers and non-carriers...

  • LRRK2, 2010
    Genetic and Environmental Modifiers for LRRK2-Associated PD

    Objective/Rationale: 
    In the last decades, mutations of several genes have been found to cause familial Parkinson’s disease (PD) and variants of these genes can also increase the risk for developing...

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