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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2014
    The Microbiome in Parkinson's Disease: Role as a Potential Biomarker and Relation to Disease Progression

    Promising Outcomes of Original Grant:
    In their previous study these researchers investigated whether the abundance of different microbes in the gut differs between Parkinson’s disease (PD) patients and...

  • Rapid Response Innovation Awards, 2014
    Parc (a Parkin-related E3 Ligase): Functions in Neuronal Survival and Parkinson’s Disease

    Objective/Rationale:
    Parkinson’s disease (PD) is frequently associated with mutations in the gene that encodes Parkin, a protein that detects and degrades dysfunctional mitochondria. While removing...

  • Research Grant, 2014
    Anti-dyskinetic Activity of the Selective 5-HT1A Agonist NLX-112: Behavioral and Microdialysis Studies

    Promising Outcomes of Original Grant:
    These researchers are investigating the activity of novel drugs that potently activate serotonin 5-HT1A receptors. Targeting this receptor subtype is an attractive...

  • Access to Data and Biospecimens, 2014
    Effect of LRRK2 Mutations on PD-associated Inflammation

    Objective/Rationale:
    Increased inflammation is associated with the progression and possibly even onset of Parkinson’s disease (PD). Mutations in the LRRK2 gene are also associated with PD, and recent...

  • Access to Data and Biospecimens, 2014
    Defining Non-motor Phenotypes in Parkinson’s Disease and Novel Strategies for Diagnosis

    Objective/Rationale:
    Although Parkinson’s disease (PD) is diagnosed as a movement disorder, motor deficits are preceded by non-motor features including cognitive, cardiovascular, gastrointestinal...

  • LRRK2 Role in Idiopathic Parkinson's Disease, 2014
    Age-related Alterations in LRRK2 Expression and Function in Immune Cells and Risk for Idiopathic Parkinson's Disease

    Objective/Rationale:
    The LRRK2 protein is highly expressed in immune cells, but its function is unknown and may change as the immune system changes with aging and environmental exposures, the largest...

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