The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2023Subtyping Parkinson’s Disease Using Genetic and Intestinal Inflammation Biomarkers
Study Rationale: Although Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, no drugs are currently available to treat or prevent the condition because the...
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Parkinson’s Disease Therapeutics Pipeline Program, 2023Development of Parkin Activators for the Treatment of Parkinson’s Disease
Study Rationale: Impaired function of cell structures called mitochondria plays a key role in the pathology of Parkinson’s disease (PD): alpha-synuclein accumulation damages mitochondria, dopamine...
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Research Grant, 2023Development of a Protein Biomarker Panel to Measure Parkinson’s Disease Heterogeneity and Progression
Study Rationale: According to The Michael J. Fox Foundation, the need for biomarkers that provide an objective assessment for Parkinson’s disease (PD) “has become more urgent as more projects enter...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Developing Small Molecules to Enhance Autophagy and Clear Alpha-synuclein Aggregates as a Treatment for Parkinson’s Disease
Study Rationale: Autophagy is a process by which cells dispose of damaged or improperly functioning cell components. Recent evidence points at defects in autophagy as a feature of Parkinson’s disease...
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Accelerating the Translation of Parkinson's Disease Therapies, 2023Evaluating Polyamines as Biomarkers for Parkinson’s Disease
Study Rationale: One of genes associated with Parkinson’s disease (PD), ATP13A2, regulates the levels of polyamines in the lysosome, an acidic compartment of the cell. Polyamines are neuroprotective...
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Research Grant, 2023Characterizing the Immune Cells Present in the Blood and Cerebrospinal Fluid of People with Parkinson's Disease Associated with Mutations in LRRK2
Study Rationale: Several studies have demonstrated that people with Parkinson’s disease (PD) have an altered frequency of immune cells in the blood. In addition, immune cells that normally patrol the...
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Our funding programs support basic, translational and clinical research from academia and industry.