The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2023Validation of Gap Junction Proteins as a New Therapeutic Target for Impeding the Cell-to-cell Spread of Alpha-synuclein in Parkinson’s Disease and Related Synucleinopathies
Study Rationale:The gap junctions that directly connect one cell with its neighbor have recently been implicated in the transfer of alpha-synuclein pathology associated with Parkinson’s disease (PD)...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2022Advancing Biological Understanding of PINK1 and Parkin Rodent Models of Parkinson’s Disease
Study Rationale: Although loss-of-function mutations in the PINK1 and Parkin genes are known to cause early onset Parkinson’s disease (PD), the cellular and molecular mechanisms remain uncertain. We...
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Research Grant, 2023Allogeneic Bone marrow-derived Mesenchymal Stem Cells as a Disease-modifying Therapy for Idiopathic Parkinson’s Disease: Phase 2a Double-Blind, Randomized Controlled Trial
Study Rationale: Chronic neuroinflammation plays a critical role in the development and progression of Parkinson’s disease (PD). Neuroinflammation damages the brain microenvironment, disrupts the...
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Translational Pipeline Program, 2023Using Cellular Approaches to Deep Brain Stimulation to Revert Gait Disorders
Study Rationale: Gait deficits in Parkinson’s disease (PD) are not well controlled with existing therapeutic strategies. Episodic gait deficits such as freezing of gait are particularly debilitating...
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Research Grant, 2023Non-Invasive Method for Recovering Protein Biomarkers in Parkinson’s Disease
Study Rationale: There is a need for simple methods to improve the diagnosis of Parkinson’s disease (PD) before individuals ever experience symptoms. Focused ultrasound technology can alter the walls...
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Cellular Phenotyping in Human iPSCS from the PPMI Cohort, 2022Defining Mechanisms in Different Brain Cells that Drive Progression in Parkinson’s Disease
Study Rationale: The death of dopamine-producing neurons is the defining feature of Parkinson’s disease (PD), leading to the motor symptoms characteristic of the disorder. Given this obvious...
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Our funding programs support basic, translational and clinical research from academia and industry.