The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2021Pre-clinical Validation of a Novel Target for Dyskinesia Induced by Levodopa
Study Rationale:
The motor symptoms associated with Parkinson’s disease (PD) are treated by replacing dopamine, the brain chemical that is lost when dopamine-producing neurons die. Initially... -
Target Advancement Program, 2021Targeting the Chemical Modification of DNA to Suppress Neurodegeneration in Parkinson’s Disease
Study Rationale:
Genes can be switched on or off by proteins that add and remove chemical modifications to DNA. We and others have shown that the chemical modification of genes important for... -
Priority Biology, 2021Gene Expression Changes Induced by Alpha-Synuclein
Study Rationale:
Deposits of the alpha-synuclein protein are the key cellular pathology recognized to drive the progression of Parkinson’s disease leading to the death of neurons. The alpha-synuclein... -
Research Grant Supplement, 2021Profiling the Removal of Damaged Mitochondria in Stem Cell-Derived Brain Cells from People with Parkinson’s
Promising Outcomes of Original Grant:
Our previous work has shown that metabolic failure plays a critical role in the pathology of Parkinson’s disease (PD). A plethora of evidence from different... -
Biosample Use Program, 2021Evaluating Neurotoxic Metabolites as Biomarkers of Parkinson’s Progression
Study Rationale:
Individuals with Parkinson’s disease (PD) show elevated markers of inflammation in their brains, cerebrospinal fluid and blood. We think that inflammation drives the worsening of... -
Therapeutic Pipeline Program, 2021Directed Evolution of Tailor-Made Molecular Chaperones
Study Rationale:
For cells to operate properly, the proteins they produce must fold properly and maintain the correct three-dimensional structure. This process relies on a special class of proteins...
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Our funding programs support basic, translational and clinical research from academia and industry.