The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Biosample Use Program, 2020Mass Spectrometric Analysis of Glucocerebrosidase Protein Levels and Spinal Fluid in People with Parkinson’s
Study Rationale:
Mutations in the glucocerebrosidase (GBA) gene are among the most important risk factors for developing Parkinson´s disease. GBA activity is reduced in cerebrospinal fluid (CSF) of... -
Priority Biology, 2021LRRK2 Regulation of Melanoma Progression
Study Rationale:
People with Parkinson's disease (PD) are more likely to develop melanoma, and people with melanoma are more likely to develop PD than the general population. Additionally, melanoma... -
Research Grant, 2020Alpha-synuclein Toxicity in LRRK2 Knock-in Models and Rescue by LRRK2 Silencing
Study Rationale:
Gene mutations that alter the function of the LRRK2 protein are known to increase the risk of developing Parkinson’s disease (PD). One of the pathological hallmarks of PD is the... -
Research Grant, 2020Evaluation of ANAVEX2-73 (blarcamesine) in Participants with Parkinson’s Disease
Study Rationale:
We are testing ANAVEX2-73 (also known as blarcamesine), which previous research has shown helps improve behaviors as well as normalizes biochemical changes in a Parkinson’s... -
Therapeutic Pipeline Program, 2021Brain-penetrating Antisense Oligonucleotide to Down-regulate Alpha-synuclein
Study Rationale:
Antisense oligonucleotides (ASOs) are a new type of therapeutic that have promise for treating Parkinson’s disease. They act by modifying the production of specific proteins, such as... -
, 2020The Role of USP30 in Idiopathic Parkinson’s Disease
Study Rationale:
Dopamine neurons are highly vulnerable to age-dependent increases in mitochondrial dysfunction, oxidative stress, and protein accumulation due to their high metabolic activity...
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Our funding programs support basic, translational and clinical research from academia and industry.