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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Spring 2022 RFP: Expanding Biological Understanding of Parkinson's Disease, 2022
    Assessing Genetic Predisposition to Gastrointestinal Symptoms in Young-onset and Late-onset Parkinson’s Disease

    Study Rationale: Constipation is a common, nonmotor manifestation of Parkinson’s disease (PD) that can impact the quality of life of people with the condition. Yet little is known about the genetic...

  • Research Grant, 2022
    Evaluation of a Monitoring System Based on a Wearable Sensor for Improving Swallowing and Saliva Control in Parkinson’s Disease

    Study Rationale: Trouble with swallowing and increased drooling are common issues for people with Parkinson’s disease (PD). These oral symptoms occur in up to 80% of cases. Our prior work showed that...

  • Summer 2022 RFP: Expanding Biological Understanding of Parkinson's Disease, 2022
    Assessing Whether Cholesterol or Its Metabolites Increase the Risk of Developing Parkinson’s Disease

    Study Rationale: Parkinson’s disease (PD) has been associated with a dysregulation of cholesterol metabolism in brain cells and the accumulation of a protein called alpha-synuclein. Our research is...

  • Research Grant, 2022
    Performing a First-In-Human Study of a Retinal Tracer For Alpha-synuclein in Parkinson's Disease

    Study Rationale: Like the brain, the retina is part of the central nervous system. We therefore aim to develop a new and simple way to diagnose Parkinson’s disease (PD) via examination of the eye. To...

  • Summer 2022 RFP: Accelerating the Translation of Parkinson's Disease Therapies, 2022
    Developing an Inhibitor of Transglutaminase 2 as a Disease-modifying Treatment for Parkinson’s Disease

    Study Rationale: Clumping of alpha-synuclein in the brain is a key pathological feature of Parkinson’s disease (PD) and is believed to lead to brain cell degeneration. Identifying factors that...

  • Spring 2022 RFA: Target Advancement Program - Target Validation, 2022
    Evaluating an Insulin-degrading Enzyme as a Novel Therapeutic Target for Parkinson’s Disease

    Study Rationale: In Parkinson’s disease (PD), the clumping of the protein alpha-synuclein in the brain causes the death of neurons. Recent studies have shown that the insulin-degrading enzyme (IDE)...

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