The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2018Development of ALK4290 as a Novel Parkinson's Therapeutic
Study Rationale:
There is clear evidence that the immune system plays an important role in the development and progression of Parkinson's disease. Novel therapies targeting the recruitment of immune... -
Target Advancement Program, 2018Searching for Cellular Changes Associated with PINK1 and PRKN Mutations
Study Rationale:
PINK1 and parkin are two proteins that work together to keep cells healthy by ridding them of damaged mitochondria, cells' powerhouses. Mutations (changes) in the PINK1 and PRKN genes... -
Target Advancement Program, 2018Validation of CD4 T Cell Dependent Neurotoxicity in an Alpha-Synuclein Model of Parkinson's Disease
Study Rationale:
Microglia, an immune cell in the brain, takes up unneccessary alpha-synuclein proteins and passes it on to the major histocompatibility complex (MHCII). This involves an interaction... -
Therapeutic Pipeline Program, 2018Dual Leucine Zipper Kinase Inhibitors for Parkinson's Disease
Study Rationale:
There are no therapies that slow down the loss of brain cells affected by Parkinson's disease. Prior research suggests that dual leucine zipper kinase (DLK) regulates stress response... -
Research Grant, 2018Peripheral Inflammatory Cytokine Profiling in Parkinson's Disease
Study Rationale:
A growing body of research suggests that inflammation contributes to Parkinson's disease. However, the stages in the disease process that inflammation is prevalent and important are... -
Research Grant, 2018Conformational Changes in the Activation of the Ubiquitin Ligase Parkin
Study Rationale:
Parkin is an enzyme that modifies proteins on mitochondria in response to damage. In previous MJFF-funded research, we examined how Parkin changes its conformation as it goes from an...
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Our funding programs support basic, translational and clinical research from academia and industry.