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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • LRRK2 Biology Consortium, 2017
    Identification of Network, Activity and Behavioral Signatures of LRRK2 Expression

    Promising Outcomes of Original Grant:
    Our original project investigated how the LRRK2 mutation, the principal genetic cause of Parkinson's disease (PD), alters brain activity involved in movement...

  • Research Grant, 2016
    Investigation of the Role of PINK1-dependent Phosphorylation of Rab GTPases in Parkinson’s Disease

    Study Rationale:
    Mutations in the PINK1 gene lead to Parkinson’s disease. PINK1 belongs to a special class of enzymes known as protein kinases. We recently found that PINK1 targets a family of enzymes...

  • Priority Target Award, 2016
    Advancing PINK1 Knockout Models of Parkinson’s

    Study Rationale:
    Loss-of-function mutations in PINK1 are causally linked to early-onset Parkinson’s disease (PD). MJFF funded the generation and initial characterization of PINK1 knockout (KO) models...

  • Therapeutic Pipeline Program, 2016
    KH176 as a Novel Disease-modifying Therapeutic for Parkinson’s Disease

    Study Rationale:
    Mitochondrial dysfunction has a prominent role in the process of Parkinson’s disease (PD). Mutations in at least seven genes are known to underlie PD, most of them encode proteins that...

  • Therapeutic Pipeline Program, 2016
    Long-term Cell Restorative Treatment for Parkinson’s Disease

    Study Rationale:                   
    Cell replacement therapies for Parkinson’s disease (PD) propose to replace the lost dopaminergic neurons in the brain. Transplanted fetal dopamine neurons have...

  • Therapeutic Pipeline Program, 2016
    USP13 Regulation of Parkin Stability

    Study Rationale:                   
    Our data show that the enzyme USP13 is dramatically increased (two-fold) in sporadic Parkinson’s brains, and cell culture studies suggest that USP13 de-ubiquitinates...

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