The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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GBA Biology and Therapies, 2018Targeting GCase with Novel Pharmacological Chaperones
Study Rationale:
People who have mutations in the GBA gene have a higher chance of developing Parkinson's disease (PD). The GBA gene encodes the glucerebrosidase (GCase) protein, an enzyme located... -
GBA Biology and Therapies, 2018Impact of Genetic Variants in GBA on Parkinson’s Disease
Study Rationale:
Changes to the DNA sequence are risk factors for Parkinson’s disease. While we know where many of these changes occur in our DNA, we still do not know how they cause Parkinson’s... -
GBA Biology and Therapies, 2019Identification of Targets of Neurotoxic Sphingolipids Using iPSCs from People with GBA-associated Parkinson’s Disease
Study Rationale:
GBA encodes the enzyme beta-glucocerebrosidase (GCase), which is required to maintain function of the cell’s lysosomes, which break down unnecessary cellular parts. Mutations in GBA... -
GBA Biology and Therapies, 2018Genotypic Influences on Network Progression in Parkinson’s Disease
Study Rationale:
Parkinson’s disease patients with mutations in the glucocerebrosidase (GBA) gene tend to have a more aggressive disease course. GBA pathways may therefore constitute a discrete target... -
GBA Biology and Therapies, 2018Sphingolipid and Alpha-synuclein Interactions
Study Rationale:
In Parkinson’s, a normal cellular protein called alpha-synuclein begins to fold incorrectly (misfold), and this has a central role in the development of the disease. Our research... -
GBA Biology and Therapies, 2018Molecular Imaging and Computer Typing in GBA-PD and Asymptomatic GBA-mutation Carriers
Study Rationale:
People who have a mutation in the GBA gene have a higher risk of developing Parkinson’s disease (PD) and, if they have PD, are more likely to have cognitive decline and dementia...
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