The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Tracing Hallmarks of Parkinson's Disease in the Brain with a New Compound
Study Rationale:
Parkinson's disease (PD) is characterized by the presence of protein alpha-synuclein clumps in the brain. PD shares common features with other neurodegenerative diseases and because an... -
LRRK2 Biology Consortium, 2018Developing Cell-Based Tools for the Evaluation of LRRK2 Inhibitors
Promising Outcomes of Original Grant:
Mutations in the LRRK2 gene are a leading genetic cause of Parkinson's disease (PD) and cause dysfunction in the LRRK2 protein. We have previously demonstrated... -
Research Grant, 2018Developing a Reliable Clinical Test for pS129 Alpha-synuclein
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). An abnormal form of the protein, called pS129 alpha-synuclein, can serve as an... -
Mitochondrial Biomarkers, 2018Studying Changes in Phosphatidylethanolamine as a New Marker of Parkinson's Disease
Study Rationale:
While most cases of Parkinson's disease (PD) have no known cause, some are caused by changes (mutations) in genes such as SNCA, which regulates the production of a protein called alpha... -
Research Grant, 2016Patient-Carer-Provider Communication about the Impact of Motor and Non-motor Fluctuations
Study Rationale:
Temporary periods of poor mobility and other symptoms (OFF periods) are common in Parkinson’s disease and are associated with poorer quality of life. OFF symptoms are complex, with... -
Target Advancement Program, 2019Identifying Protein Sequence of Potential Drug Target Synuclein Nitrase
Study Rationale:
We have found that alpha-synuclein nitration and aggregation — which may play a role in Parkinson’s disease — is catalyzed by an enzyme that we have termed synuclein nitrase. In this...
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Our funding programs support basic, translational and clinical research from academia and industry.