The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Validation of KLK6 as a New Therapeutic Target for Parkinson’s Disease
Study Rationale: Alpha-synuclein is the main protein that aggregates and forms Lewy bodies, the hallmark histological characteristics of Parkinson disease (PD). Multiple experimental studies suggest...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Implementation and Validation of Lysosome-specific Tests of GCase Activity in Cell Lines and Human Peripheral Blood
Study Rationale: Glucocerebrosidase (GCase) is an enzyme that is linked to Parkinson’s disease (PD) and is a high value target for disease-modifying treatments. Developing robust methods for...
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Novel PET Tracer Development Program, 2023Monitoring Glucocerebrosidase Engagement in Parkinson’s Disease
Study Rationale: Glucocerebrosidase is an enzyme that is essential for maintaining healthy lipid metabolism throughout the human body. In Parkinson’s disease (PD), the efficiency of this protein is...
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Research Grant, 2023Developing Wiring Diagrams of the Brain-Body Connection
Study Rationale: Individuals with Parkinson’s disease (PD) can show a variety of symptoms, including: resting tremors, alterations in directed hand movements, and treatment-induced dyskinesias; loss...
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Data-Driven Subtyping and Stratification Program, 2023Identifying Proteomic Biomarkers for Monitoring the Progression of Parkinson’s Pathophysiology
Study Rationale: Parkinson’s disease (PD) is often diagnosed at a stage where the disease has progressed significantly, restricting treatment options and limiting the opportunity to understand how the...
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Circuits & Cellular Targets for PD’s Symptoms, 2023Pathophysiology of Neural Circuits Underlying Pain in Prodromal to Advanced Parkinson’s Disease
Study Rationale: Many people with Parkinson’s disease (PD) suffer from pain that is not managed well by existing therapies. We believe the ineffectiveness of these treatment strategies may be due to a...
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Our funding programs support basic, translational and clinical research from academia and industry.