Study Rationale: LRRK2 variants are the most common cause of autosomal dominant Parkinson’s disease yet the natural history of LRRK2 Parkinson’s disease is not fully understood. While multiple LRRK2 Parkinson’s disease observational studies have been conducted, most have been small, and few have included long-term follow-up. To improve the likelihood of success in future LRRK2 Parkinson’s disease clinical trials, we need a better understanding of progression in LRRK2 Parkinson’s disease. Pooling data from multiple LRRK2 Parkinson’s disease cohorts will improve our ability to conduct analyses that will inform understanding of the clinical and biological progression of LRRK2 Parkinson’s disease across the continuum.
Hypothesis: We hypothesize that pooling and analyzing data from existing LRRK2 Parkinson’s disease cohorts will help fill gaps in the understanding of the natural history of LRRK2 Parkinson’s disease and identify opportunities to improve data collection.
Study Design: During this planning grant, we will establish the team, structures, and processes needed to move forward with the pooling and analysis of data from existing LRRK2 Parkinson’s disease cohorts. Specifically, we will identify and review existing LRRK2 Parkinson’s disease cohorts, evaluate potential restrictions that may limit data sharing, establish a steering committee to guide our efforts, and define the key analyses to be conducted.
Impact on Diagnosis/Treatment of Parkinson’s disease: This work will help inform the design of LRRK2 Parkinson’s disease clinical trials and ultimately speed therapeutic development.
Next Steps for Development: The next step will be to pool and analyze clinical, genetic, biological, digital, and neuroimaging data from existing LRRK2 Parkinson’s disease cohorts.