To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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SNCAbow Mouse*
Mouse Model
Mouse expressing either nuclear localized SNCAWT:TagBFP, SNCAA30P:mTFP1, or SNCAA53T:mKO2 in cre-expressing tissues of the offspring directed by CAG promoter followed by three pairs of orthogonal lox sites (LoxN, Lox2272, and LoxP), and the SNCAbow construct; all targeted into the Gt(ROSA)26Sor locus. Each α-synuclein sequence contains a C-terminal epitope tag: SNCAWT tagged with V5, SNCAA30P tagged with 3XHA, or SNCAA53T tagged with Myc. Model was generated by Rodger Liddle at Duke University Medical Center and deposited through the MJFF Sponsored Tools Program as part of the Aligning Science Across Parkinson’s (ASAP) Initiative. RRID:IMSR_JAX:037603
RILPL2 Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse RILPL2 for immunoblotting applications. This antibody development project is part of the Aligning Science Across Parkinson’s (ASAP) Initiative. Estimated Availability: Late 2025
MHC-I Db/Kb Antibody
Antibody
Rabbit monoclonal antibody directed against mouse MHC-I H2-Db and H2-Kb for immunoblotting and immunostaining applications. This antibody development project is part of the Aligning Science Across Parkinson’s (ASAP) Initiative. Estimated Availability: Early 2026
S69R Rab32 KI Mouse
Mouse Model
CRISPR/Cas9 genome targeting strategy to knockin S69R point mutation in the endogenous mouse Rab32 gene (corresponds to the S71R mutation in human Rab32).
PINK1 KO Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockout PINK1 on a Sprague Dawley rat background.
A2a-Flp Mouse*
Mouse Model
A2a-FlpO knock-in mice express optimized Flp recombinase (FlpO) from the mouse Adora2a promoter and enable the targeting of Adora2a-expressing cells and the indirect pathway spiny projection neuronal (iSPN) subpopulation of neurons in the striatum. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
D1-Cre Mouse*
Mouse Model
D1-Cre knock-in express Cre recombinase from the mouse Drd1 promoter and enable the targeting of Drd1-expressing cells and the direct pathway spiny projection neuronal (dSPN) subpopulation of neurons in the striatum. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
D1-Flp Mouse*
Mouse Model
D1-FlpO knock-in expresses optimized Flp recombinase (FlpO) from the mouse Drd1 promoter and enables the targeting of Drd1-expressing cells and the direct pathway spiny projection neuronal (dSPN) subpopulation of neurons in the striatum. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
SYNJ1 Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in CTSB for heterozygous and homozygous R219Q mutations.These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
A2a-Cre Mouse*
Mouse Model
A2a-Cre knock-in mice express Cre recombinase from the mouse Adora2a promoter and enable the targeting of Adora2a-expressing cells and the indirect pathway spiny projection neuronal (iSPN) subpopulation of neurons in the striatum. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
Have questions or need additional information?
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"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic