To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Bead-Conjugated TMEM192 Antibody (Ms)
Antibody
Magnetic bead-conjugated rabbit monoclonal antibody directed against mouse TMEM192 for immunoprecipitation of lysosomes. An unconjugated version of this antibody is also available. This antibody was generated by Dr. Dario Alessi at the University of Dundee and deposited through the MJFF Sponsored Tools Program as part of the Aligning Science Across Parkinson’s (ASAP) Initiative.
Bead-Conjugated TMEM192 Antibody (Hu)
Antibody
Magnetic bead-conjugated rabbit monoclonal antibody directed against human TMEM192 for immunoprecipitation of lysosomes. An unconjugated version of this antibody is also available. This antibody was generated by Dr. Dario Alessi at the University of Dundee and deposited through the MJFF Sponsored Tools Program as part of the Aligning Science Across Parkinson’s (ASAP) Initiative. For 500uL and 1mL aliquot sizes, use MJFF discount code MJFFAB. Custom orders are recommended if volume needs exceed 1mL.
Alpha-Synuclein Preformed Fibril Protein*
Protein
Aggregated alpha-synuclein protein intended for use in synuclein seeding experiments. Unfortunately this protein is no longer available as ND BioSciences closed.
LRRK2 KO Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockout LRRK2 on a Sprague Dawley rat background.
Alpha-Synuclein Aggregation Assay in Immortalized Neurons
In Vitro Assays
High-throughput in vitro assay to detect alpha-synuclein aggregation developed in a dopamine neuron-like cell line of human origin. Available as a fee-for-service assay. Generated as part of the Industry Tools Consortium.This assay was discontinued. A similar assay using iPSC-derived dopamine neurons is in development.
Alpha-Synuclein Aggregation Assay in iPSC-derived Neuron-Astrocyte Co-Culture
In Vitro Assays
High-throughput in vitro assay to detect alpha-synuclein pathology in iPSC-derived neuron and astrocyte co-culture system treated with alpha-synuclein pre-formed fibrils. Available as a fee-for-service assay. Estimated Availability: Late 2027
Alpha-Synuclein Aggregation Assay in iPSC-derived Dopamine Neurons
In Vitro Assays
High-throughput in vitro assay to detect alpha-synuclein pathology in iPSC-derived dopamine neurons treated with alpha-synuclein pre-formed fibrils. Available as a fee-for-service assay. Estimated Availability: Late 2027
Nuclear Emulsion for Autoradiography
Chemical
High-sensitivity photographic emulsion for microautoradiography studies to visualize distribution of radioactive tracers in tissue sections/cell preparations.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic