MJFF Publications

Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease

2025

OPEN

Title: Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease

Author(s): Shijun Yan, Wenjing Zhang, Xinying Li, Suman Dutta, Andrew R. Castle, Yiming Liu, Akhila K. Sahoo, C. Lam, Nicholas J.F. Gatford, Joshua Shulman, Chenzhong Li, Cheng Jiang, Bowen Shu, George K. Tofaris

Journal Name: Cell Reports Medicine

Publisher: Elsevier BV

Vol: 6

Issue #: 3

Start Page: 101999

End Page: 101999

Publication Date: 2025-03-01

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1016/j.xcrm.2025.101999

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A long-lived pool of PINK1 imparts a molecular memory of depolarization-induced activity

2025

OPEN

Title: A long-lived pool of PINK1 imparts a molecular memory of depolarization-induced activity

Author(s): Liam Pollock, Ioanna Ch. Georgiou, Emma V. Rusilowicz-Jones, Michael J. Clague, Sylvie Urbé

Journal Name: Science Advances

Publisher: American Association for the Advancement of Science (AAAS)

Vol: 11

Issue #: 9

Start Page:

End Page:

Publication Date: 2025-02-28

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1126/sciadv.adr1938

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Benchmarking macaque brain gene expression for horizontal and vertical translation

2025

OPEN

Title: Benchmarking macaque brain gene expression for horizontal and vertical translation

Author(s): Andrea I. Luppi, Zhen-Qi Liu, Justine Y. Hansen, Rodrigo Cofré, Meiqi Niu, Elena Kuzmin, Seán Froudist‐Walsh, Nicola Palomero‐Gallagher, Bratislav Mišić

Journal Name: Science Advances

Publisher: American Association for the Advancement of Science (AAAS)

Vol: 11

Issue #: 9

Start Page:

End Page:

Publication Date: 2025-02-28

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1126/sciadv.ads6967

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Quantifying arm swing in Parkinson’s disease: a method accounting for arm activities during free-living gait

2025

OPEN

Title: Quantifying arm swing in Parkinson’s disease: a method accounting for arm activities during free-living gait

Author(s): Erik Post, Twan van Laarhoven, Yordan P. Raykov, Max A. Little, Jorik Nonnekes, Tom Heskes, Bastiaan R. Bloem, Luc J. W. Evers

Journal Name: Journal of NeuroEngineering and Rehabilitation

Publisher: Springer Science and Business Media LLC

Vol: 22

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-26

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1186/s12984-025-01578-z

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A framework to standardize gait study protocols in Parkinson's disease

2025

OPEN

Title: A framework to standardize gait study protocols in Parkinson's disease

Author(s): Martina Mancini, Jeffrey M. Hausdorff, Elisa Pelosin, Paolo Bonato, Richard Camicioli, Terry D. Ellis, Jochen Klucken, Larry Gifford, Alfonso Fasano, Alice Nieuwboer, Catherine Kopil, Katharina Klapper, L. Kirsch, David T. Dexter, Rosie Fuest, Vonda H. Miller, Angelica Asis, Martijn L.T.M. Müller, Diane Stephenson, Anat Mirelman

Journal Name: Journal of Parkinson’s Disease

Publisher: SAGE Publications

Vol: 15

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-25

Open Access(OA) Status: OPEN

License: cc-by-nc

DOI - Digital Object Identifier: 10.1177/1877718x241305626

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A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

2025

OPEN

Title: A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

Author(s): Friederike Grandke, Tobias Fehlmann, Fabian Kern, David Gate, Tobias William Wolff, Olivia Leventhal, Divya Channappa, Pascal Hirsch, Edward N. Wilson, Eckart Meese, Chuanyu Liu, Quan Shi, Matthias Flotho, Yongping Li, Cynthia Chen, Yeya Yu, Jiangshan Xu, Michael Junkin, Zhifeng Wang, Tao Wu, Longqi Liu, Yong Hou, Katrin I. Andreasson, Jennifer Gansen, Elvira Mass, Kathleen L. Poston, Tony Wyss‐Coray, Andreas Keller

Journal Name: Nature Communications

Publisher: Springer Science and Business Media LLC

Vol: 16

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-25

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41467-025-56833-7

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Transcriptomic responses of lung mesenchymal cells during pneumonia

2025

OPEN

Title: Transcriptomic responses of lung mesenchymal cells during pneumonia

Author(s): Alicia M. Soucy, J Brune, Archana Jayaraman, Anukul T. Shenoy, F.T. Korkmaz, Neelou Etesami, Bradley E. Hiller, Ian Martin, Wesley N. Goltry, C. Ha, Nicholas A. Crossland, Joshua D. Campbell, Thomas G. Beach, K. Traber, Matthew R. Jones, Lee J. Quinton, Markus Bosmann, Charles W. Frevert, Joseph P. Mizgerd

Journal Name: JCI Insight

Publisher: American Society for Clinical Investigation

Vol: 10

Issue #: 7

Start Page:

End Page:

Publication Date: 2025-02-25

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1172/jci.insight.177084

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RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress

2025

OPEN

Title: RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress

Author(s): Janna Jernigan, Hannah A. Staley, Zachary Baty, MacKenzie L. Bolen, Beatriz Maffini Gomes, Jenny Holt, Cassandra L. Cole, Noelle Neighbarger, Kruthika Dheeravath, Andrea R. Merchak, Kelly B. Menees, Stephen A. Coombes, Malú G. Tansey

Journal Name: Journal of Neuroinflammation

Publisher: Springer Science and Business Media LLC

Vol: 22

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-24

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1186/s12974-024-03322-1

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Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant

2025

OPEN

Title: Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant

Author(s): Shen‐Yang Lim, Tzi Shin Toh, Jia Wei Hor, Jia Lun Lim, Lei Cheng Lit, Azlina Ahmad, Yi Wen Tay, Jia Nee Foo, Ebonne Yulin Ng, Kalai Arasu Muthusamy, Norlinah Mohamed Ibrahim, Khairul Azmi Ibrahim, Louis C.S. Tan, Jannah Zulkefli, Anis Nadhirah Khairul Anuar, Kirsten Black, Paweł Lis, Fei Xie, Zhidong Cen, Kai Shi Lim, Katja Lohmann, Shalini Padmanabhan, Dario R. Alessi, Wei Luo, Eng‐King Tan, Esther Sammler, Ai Huey Tan

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-23

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41531-025-00884-6

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Citation Count: 1

AskBeacon—Performing genomic data exchange and analytics with natural language

2025

OPEN

Title: AskBeacon—Performing genomic data exchange and analytics with natural language

Author(s): Anuradha Wickramarachchi, Shakila Tonni, S. Majumdar, Sarvnaz Karimi, Sulev Kõks, Brendan Hosking, Jordi Rambla, Natalie A. Twine, Yatish Jain, Denis C. Bauer

Journal Name: Bioinformatics

Publisher: Oxford University Press (OUP)

Vol: 41

Issue #: 3

Start Page:

End Page:

Publication Date: 2025-02-22

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1093/bioinformatics/btaf079

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Predicting Parkinson’s disease trajectory using clinical and functional MRI features: A reproduction and replication study

2025

OPEN

Title: Predicting Parkinson’s disease trajectory using clinical and functional MRI features: A reproduction and replication study

Author(s): Élodie Germani, Nikhil Bhagwat, Mathieu Dugré, Rémi Gau, Albert Montillo, Kevin P. Nguyen, Andrzej Sokołowski, Madeleine Sharp, Jean‐Baptiste Poline, Tristan Glatard

Journal Name: PLOS ONE

Publisher: Public Library of Science (PLoS)

Vol: 20

Issue #: 2

Start Page: e0317566

End Page: e0317566

Publication Date: 2025-02-21

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1371/journal.pone.0317566

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Exploring the early drivers of pain in Parkinson’s disease

2025

OPEN

Title: Exploring the early drivers of pain in Parkinson’s disease

Author(s): Shiying Liu, Douglas D. Gunzler, Steven A. Gunzler, Dana C. Crawford, Farren Briggs

Journal Name: Scientific Reports

Publisher: Springer Science and Business Media LLC

Vol: 15

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-20

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1038/s41598-025-90678-w

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Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease

2025

OPEN

Title: Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease

Author(s): Asier Erramuzpe, Ane Murueta‐Goyena, Antonio Jiménez-Marín, M. Acera, Sara Teijeira‐Portas, Rocío Del Pino, Tamara Fernández, Ibai Díez, Unai Sainz‐Lugarezaresti, Naroa Ibarretxe‐Bilbao, Unai Ayala, Maitane Barrenechea, Alberto Cabrera‐Zubizarreta, Jesús M. Cortés, Juan Carlos Gómez‐Esteban, Iñigo Gabilondo

Journal Name: Annals of Clinical and Translational Neurology

Publisher: Wiley

Vol: 12

Issue #: 4

Start Page:

End Page:

Publication Date: 2025-02-17

Open Access(OA) Status: OPEN

License:

DOI - Digital Object Identifier: 10.1002/acn3.70007

Best OA location URL: https://doi.org/10.1002/acn3.70007

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Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei

2025

OPEN

Title: Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei

Author(s): Vasileios Theologidis, Sara A. Ferreira, Nanna Møller Jensen, Diana Gomes Moreira, Ole A. Ahlgreen, Mads W. Hansen, Emilie D. Rosenberg, Mette Richner, Islam Faress, Hjalte Gram, Poul Henning Jensen, Per Borghammer, Jens R. Nyengaard, Marina Romero‐Ramos, Christian B. Vægter, Wilma D.J. van de Berg, Nathalie Van Den Berge, Asad Jan

Journal Name: Acta Neuropathologica Communications

Publisher: Springer Science and Business Media LLC

Vol: 13

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-17

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1186/s40478-025-01948-7

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Updated MDSGene review on the clinical and genetic spectrum of LRRK2 variants in Parkinson´s disease

2025

OPEN

Title: Updated MDSGene review on the clinical and genetic spectrum of LRRK2 variants in Parkinson´s disease

Author(s): Cleusa Adriane Menegassi Bianchi Krüger, Shen‐Yang Lim, Alissa Buhrmann, Fenja L. Fahrig, Carolin Gabbert, Natascha Bahr, Harutyun Madoev, Connie Marras, Christine Klein, Katja Lohmann

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-17

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41531-025-00881-9

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Cultural variation in trust and acceptability of artificial intelligence diagnostics for dementia

2025

OPEN

Title: Cultural variation in trust and acceptability of artificial intelligence diagnostics for dementia

Author(s): Avinash Chandra, Kaviya Senthilvel, Rifah Anjum, Ijeoma Uchegbu, Laura J. Smith, Helen Beaumont, Reshma Punjabi, S. Hussna Begum, Charles R. Marshall

Journal Name: Journal of Alzheimer’s Disease

Publisher: SAGE Publications

Vol: 104

Issue #: 3

Start Page:

End Page:

Publication Date: 2025-02-16

Open Access(OA) Status: OPEN

License:

DOI - Digital Object Identifier: 10.1177/13872877251319353

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Patient-centered brain transcriptomic and multimodal imaging determinants of clinical progression, physical activity, and treatment needs in Parkinson’s disease

2025

OPEN

Title: Patient-centered brain transcriptomic and multimodal imaging determinants of clinical progression, physical activity, and treatment needs in Parkinson’s disease

Author(s): Quadri Adewale, Ahmed Faraz Khan, Sue‐Jin Lin, Tobias R. Baumeister, Yashar Zeighami, Félix Carbonell, Daniel Ferreira, Yasser Iturria‐Medina

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-15

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1038/s41531-025-00878-4

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Self-supervised identification and elimination of harmful datasets in distributed machine learning for medical image analysis

2025

OPEN

Title: Self-supervised identification and elimination of harmful datasets in distributed machine learning for medical image analysis

Author(s): Raissa Souza, Emma A. M. Stanley, Anthony Winder, Chris Kang, Kimberly Amador, Erik Y. Ohara, Gabrielle Dagasso, Richard Camicioli, Oury Monchi, Zahinoor Ismail, Matthias Wilms, Nils D. Forkert

Journal Name: npj Digital Medicine

Publisher: Springer Science and Business Media LLC

Vol: 8

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-15

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1038/s41746-025-01499-0

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BRF110, an Orally Active Nurr1-RXRα-Selective Rexinoid, Enhances BDNF Expression without Elevating Triglycerides

2025

OPEN

Title: BRF110, an Orally Active Nurr1-RXRα-Selective Rexinoid, Enhances BDNF Expression without Elevating Triglycerides

Author(s): Xenophon Asvos, Mohamed A. El Mubarak, Theodoros Karampelas, Θεόδωρος Ράμπιας, Constantin Tamvakopoulos, Gregory Sivolapenko, Athanasios Papakyriakou, Stavros Topouzis, Demetrios K. Vassilatis, Demosthenes Fokas

Journal Name: Journal of Medicinal Chemistry

Publisher: American Chemical Society (ACS)

Vol: 68

Issue #: 4

Start Page:

End Page:

Publication Date: 2025-02-13

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1021/acs.jmedchem.4c03046

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Comparative analysis of AAV serotypes for transduction of olfactory sensory neurons

2025

OPEN

Title: Comparative analysis of AAV serotypes for transduction of olfactory sensory neurons

Author(s): Benjamin D. W. Belfort, Johnathan Jia, Alexandra R Garza, Anthony M. Insalaco, John P. McGinnis, Brandon Pekarek, Joshua Ortiz‐Guzman, Burak Tepe, Hu Chen, Zhandong Liu, Benjamin R. Arenkiel

Journal Name: Frontiers in Neuroscience

Publisher: Frontiers Media SA

Vol: 19

Issue #:

Start Page:

End Page:

Publication Date: 2025-02-13

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.3389/fnins.2025.1531122

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Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications

2025

OPEN

Title: Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications

Author(s): Alfredo Iacoangeli, Allison A. Dilliott, Ahmad Al Khleifat, Peter M. Andersen, A. Nazlı Başak, Johnathan Cooper‐Knock, Philippe Corcia, Philippe Couratier, Mamede de Carvalho, Vivian E. Drory, Jonathan D. Glass, Marc Gotkine, Yosef M Lerner, Orla Hardiman, John E. Landers, Russell L. McLaughlin, Jesús S. Mora Pardina, Karen Morrison, Susana Pinto, Mònica Povedano, Christopher E. Shaw, Pamela J. Shaw, Vincenzo Silani, Nicola Ticozzi, Philip Van Damme, Leonard H. van den Berg, Patrick Vourc’h, Markus Weber, Jan H. Veldink, Richard Dobson, Guy A. Rouleau, Ammar Al‐Chalabi, Sali M. K. Farhan

Journal Name: Journal of Neurology, Neurosurgery & Psychiatry

Publisher: BMJ

Vol:

Issue #:

Start Page: jnnp

End Page: 335364

Publication Date: 2025-02-13

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1136/jnnp-2024-335364

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Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease

2025

OPEN

Title: Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease

Author(s): Yue Xu, Durong Chen, Meiqi Dong, Yun Zhang, Hongmei Yu, Yanqing Han

Journal Name: Frontiers in Aging Neuroscience

Publisher: Frontiers Media SA

Vol: 17

Issue #:

Start Page:

End Page:

Publication Date: 2025-02-12

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.3389/fnagi.2025.1513373

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Motor and nonmotor features of p.A53T alpha-synuclein PD vs idiopathic PD: longitudinal data from the PPMI study

2025

OPEN

Title: Motor and nonmotor features of p.A53T alpha-synuclein PD vs idiopathic PD: longitudinal data from the PPMI study

Author(s): Athina‐Maria Simitsi, Evangelos Sfikas, Christos Koros, Nikolaos Papagiannakis, Ion Beratis, Dimitra Papadimitriou, Roubina Antonellou, Styliani Fragiadaki, Dionysia Kontaxopoulou, Marina Picillo, Ioanna Pachi, Ioanna Alefanti, María Stamelou, Paolo Barone, Leonidas Stefanis

Journal Name: Journal of Neurology

Publisher: Springer Science and Business Media LLC

Vol: 272

Issue #: 3

Start Page:

End Page:

Publication Date: 2025-02-12

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1007/s00415-024-12836-w

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Mitofusin 2 displays fusion-independent roles in proteostasis surveillance

2025

OPEN

Title: Mitofusin 2 displays fusion-independent roles in proteostasis surveillance

Author(s): Mariana Joaquim, Selver Altin, Maria-Bianca Bulimaga, Tânia Simões, Hendrik Nolte, Verian Bader, Camilla Aurora Franchino, Solenn Plouzennec, Karolina Szczepanowska, Elena Marchesan, Kay Hofmann, Marcus Krüger, Elena Ziviani, Aleksandra Trifunović, Arnaud Chevrollier, Konstanze F. Winklhofer, Elisa Motori, Margarete Odenthal, Mafalda Escobar‐Henriques

Journal Name: Nature Communications

Publisher: Springer Science and Business Media LLC

Vol: 16

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-10

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41467-025-56673-5

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Development and validation of a sensitive sandwich ELISA against human PINK1

2025

OPEN

Title: Development and validation of a sensitive sandwich ELISA against human PINK1

Author(s): Zahra Baninameh, Jens O. Watzlawik, Bernardo A. Bustillos, Gabriella Fiorino, Tingxiang Yan, Szymon L. Lewicki, Haonan Zhang, Dennis W. Dickson, Joanna Siuda, Zbigniew K. Wszołek, Wolfdieter Springer, Fabienne C. Fiesel

Journal Name: Autophagy

Publisher: Informa UK Limited

Vol: 21

Issue #: 5

Start Page: 1

End Page: 16

Publication Date: 2025-02-06

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1080/15548627.2025.2457915

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MJFF Publications