526 - 550 of 6451 Results
Title
Year
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OPENTitle: Measurement of LRRK2 Kinase Activity by Proximity Ligation AssayJournal Name: BIO-PROTOCOLPublisher: Bio-Protocol, LLCVol: 11Issue #: 17Start Page: e4140End Page: e4140Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.21769/bioprotoc.4140Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8443460Citation Count: 14
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OPENTitle: 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localizationJournal Name: Biochemical JournalPublisher: Portland Press Ltd.Vol: 430Issue #: 3Start Page: 393End Page: 404Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1042/bj20100483Best OA location URL: https://portlandpress.com/biochemj/article-pdf/430/3/393/878058/bj4300393.pdfCitation Count: 402
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OPENTitle: From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's diseaseJournal Name: Biochemical JournalPublisher: Portland Press Ltd.Vol: 478Issue #: 14Start Page: 2945End Page: 2951Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1042/bcj20210383Best OA location URL: https://portlandpress.com/biochemj/article-pdf/478/14/2945/918073/bcj-2021-0383.pdfCitation Count: 5
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OPENTitle: Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's diseaseJournal Name: Biochemical JournalPublisher: Portland Press Ltd.Vol: 424Issue #: 1Start Page: 47End Page: 60Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1042/bj20091035Best OA location URL: https://portlandpress.com/biochemj/article-pdf/424/1/47/659876/bj4240047.pdfCitation Count: 201
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OPENTitle: Elevated Serum Pesticide Levels and Risk of Parkinson DiseaseJournal Name: Archives of NeurologyPublisher: American Medical Association (AMA)Vol: 66Issue #: 7Start Page: 870End Page: 5Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1001/archneurol.2009.89Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3383784Citation Count: 134
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OPENTitle: The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2Journal Name: Biochemical JournalPublisher: Portland Press Ltd.Vol: 474Issue #: 9Start Page: 1547End Page: 1558Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1042/bcj20160909Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6178381Citation Count: 39
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OPENTitle: S-Nitrosylation of ApoE in Alzheimer’s DiseaseJournal Name: BiochemistryPublisher: American Chemical Society (ACS)Vol: 50Issue #: 17Start Page: 3405End Page: 3407Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/bi200266vBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3082618Citation Count: 43
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OPENTitle: Hybrid Bayesian-rank integration approach improves the predictive power of genomic dataset aggregationJournal Name: BioinformaticsPublisher: Oxford University Press (OUP)Vol: 31Issue #: 2Start Page: 209End Page: 215Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/bioinformatics/btu518Best OA location URL: https://academic.oup.com/bioinformatics/article-pdf/31/2/209/17125420/btu518.pdfCitation Count: 23
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OPENTitle: Tissue-specific network-based genome wide study of amygdala imaging phenotypes to identify functional interaction modulesJournal Name: BioinformaticsPublisher: Oxford University Press (OUP)Vol: 33Issue #: 20Start Page: 3250End Page: 3257Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/bioinformatics/btx344Best OA location URL: https://academic.oup.com/bioinformatics/article-pdf/33/20/3250/28016045/btx344.pdfCitation Count: 25
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OPENTitle: Identifying and ranking potential driver genes of Alzheimer’s disease using multiview evidence aggregationJournal Name: BioinformaticsPublisher: Oxford University Press (OUP)Vol: 35Issue #: 14Start Page: i568End Page: i576Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1093/bioinformatics/btz365Best OA location URL: https://academic.oup.com/bioinformatics/article-pdf/35/14/i568/28913444/btz365.pdfCitation Count: 16
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OPENTitle: Striatal Overexpression of ΔJunD Resets L-DOPA-Induced Dyskinesia in a Primate Model of Parkinson DiseaseJournal Name: Biological PsychiatryPublisher: Elsevier BVVol: 66Issue #: 6Start Page: 554End Page: 561Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.biopsych.2009.04.005Best OA location URL: http://doi.org/10.1016/j.biopsych.2009.04.005Citation Count: 97
- The Thorny Problem of Dyskinesias: Dendritic Spines, Synaptic Plasticity, and Striatal Dysfunction2014OPENTitle: The Thorny Problem of Dyskinesias: Dendritic Spines, Synaptic Plasticity, and Striatal DysfunctionJournal Name: Biological PsychiatryPublisher: Elsevier BVVol: 75Issue #: 9Start Page: 676End Page: 677Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.biopsych.2014.02.019Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4120525Citation Count: 1
- Selective Knockout of the Casein Kinase 2 in D1 Medium Spiny Neurons Controls Dopaminergic Function2013OPENTitle: Selective Knockout of the Casein Kinase 2 in D1 Medium Spiny Neurons Controls Dopaminergic FunctionJournal Name: Biological PsychiatryPublisher: Elsevier BVVol: 74Issue #: 2Start Page: 113End Page: 121Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.biopsych.2012.11.013Best OA location URL: http://doi.org/10.1016/j.biopsych.2012.11.013Citation Count: 46
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OPENTitle: Spatiotemporal Pattern of Striatal ERK1/2 Phosphorylation in a Rat Model of L-DOPA–Induced Dyskinesia and the Role of Dopamine D1 ReceptorsJournal Name: Biological PsychiatryPublisher: Elsevier BVVol: 62Issue #: 7Start Page: 800End Page: 810Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.biopsych.2006.11.032Best OA location URL: http://doi.org/10.1016/j.biopsych.2006.11.032Citation Count: 271
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OPENTitle: α-Synuclein Oligomers Induce a Unique Toxic Tau StrainJournal Name: Biological PsychiatryPublisher: Elsevier BVVol: 84Issue #: 7Start Page: 499End Page: 508Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.biopsych.2017.12.018Best OA location URL: https://doi.org/10.1016/j.biopsych.2017.12.018Citation Count: 77
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OPENTitle: Efficient determination of purine metabolites in brain tissue and serum by high‐performance liquid chromatography with electrochemical and UV detectionJournal Name: Biomedical ChromatographyPublisher: WileyVol: 27Issue #: 1Start Page: 122End Page: 129Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/bmc.2760Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/9979337Citation Count: 28
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OPENTitle: Efficient estimation of nonparametric genetic risk function with censored dataJournal Name: BiometrikaPublisher: Oxford University Press (OUP)Vol: 102Issue #: 3Start Page: 515End Page: 532Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/biomet/asv030Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4581539Citation Count: 7
- Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)2010OPENTitle: Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)Journal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 20Issue #: 17Start Page: 5175End Page: 5178Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2010.07.007Citation Count: 29
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OPENTitle: Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)Journal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 19Issue #: 17Start Page: 4967End Page: 4970Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2009.07.072Best OA location URL: http://doi.org/10.1016/j.bmcl.2009.07.072Citation Count: 38
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OPENTitle: Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulatorsJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 18Issue #: 20Start Page: 5626End Page: 5630Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2008.08.087Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3182458Citation Count: 58
- Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: Unexpected ‘molecular switch’ from a closely related mGlu4 positive allosteric modulator2011OPENTitle: Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: Unexpected ‘molecular switch’ from a closely related mGlu4 positive allosteric modulatorJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 21Issue #: 23Start Page: 6955End Page: 6959Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2011.09.131Citation Count: 18
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OPENTitle: Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-leadJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 19Issue #: 3Start Page: 962End Page: 966Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2008.11.104Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3787871Citation Count: 58
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OPENTitle: Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)Journal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 26Issue #: 13Start Page: 2984End Page: 2987Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2016.05.029Best OA location URL: http://doi.org/10.1016/j.bmcl.2016.05.029Citation Count: 5
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OPENTitle: Development and evaluation of [18F]Flotaza for Aβ plaque imaging in postmortem human Alzheimer’s disease brainJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 46Issue #:Start Page: 128164End Page: 128164Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2021.128164Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8379902Citation Count: 15
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OPENTitle: Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson’s Disease Brains Are Differentially Generated in Mammalian Cell ModelsJournal Name: BiomoleculesPublisher: MDPI AGVol: 5Issue #: 3Start Page: 1634End Page: 1651Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/biom5031634Best OA location URL: http://hdl.handle.net/2286/R.I.43313Citation Count: 39