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1501 - 1525 of 6557 Results
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  • An estimate of the total number of true human miRNAs
    2019
    Summary Details
    OPEN
    Title: An estimate of the total number of true human miRNAs
    Author(s): Julia Alles, Tobias Fehlmann, Ulrike Fischer, Christina Backes, Valentina Galata, Marie Minet, Martin Hart, Masood Abu‐Halima, Friedrich A. Grässer, Hans‐Peter Lenhof, Andreas Keller, Eckart Meese
    Journal Name: Nucleic Acids Research
    Publisher: Oxford University Press (OUP)
    Vol: 47
    Issue #: 7
    Start Page: 3353
    End Page: 3364
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1093/nar/gkz097
    Best OA location URL: https://academic.oup.com/nar/article-pdf/47/7/3353/28467549/gkz097.pdf
    Citation Count: 561
  • Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9
    2021
    Summary Details
    OPEN
    Title: Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9
    Author(s): Diptaman Chatterjee, David J. Marmion, Jodi L. McBride, Fredric P. Manfredsson, David Butler, Anne Messer, Jeffrey H. Kordower
    Journal Name: Gene Therapy
    Publisher: Springer Science and Business Media LLC
    Vol: 29
    Issue #: 6
    Start Page: 390
    End Page: 397
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41434-021-00244-y
    Best OA location URL: https://www.nature.com/articles/s41434-021-00244-y.pdf
    Citation Count: 52
  • Subspace corrected relevance learning with application in neuroimaging
    2024
    Summary Details
    OPEN
    Title: Subspace corrected relevance learning with application in neuroimaging
    Author(s): Rick van Veen, Neha Rajendra Bari Tamboli, Sofie Lövdal, Sanne K. Meles, Remco J. Renken, Gert-Jan de Vries, Dario Arnaldi, Silvia Morbelli, Pedro Clavero, José Á. Obeso, María Rodríguez‐Oroz, Klaus L. Leenders, Thomas Villmann, Michael Biehl
    Journal Name: Artificial Intelligence in Medicine
    Publisher: Elsevier BV
    Vol: 149
    Issue #:
    Start Page: 102786
    End Page: 102786
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1016/j.artmed.2024.102786
    Best OA location URL: https://doi.org/10.1016/j.artmed.2024.102786
    Citation Count: 8
  • Disruption of the LRRK2 substrate RAB12 facilitates neurotransmission and causes hyperactivity in mice
    2026
    Summary Details
    OPEN
    Title: Disruption of the LRRK2 substrate RAB12 facilitates neurotransmission and causes hyperactivity in mice
    Author(s): Xingjian Li, Yuanxin Chen, Huaixing Wang, Xue Zhang, Noah Guy Lewis Guiberson, Xianting Li, Jacqueline Burré, Junmin Peng, Hui Zhang, Zhenyu Yue
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 12
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41531-026-01353-4
    Best OA location URL: https://doi.org/10.1038/s41531-026-01353-4
    Citation Count: 0
  • fMRI during active GPi DBS uncovers target-specific networks
    2026
    Summary Details
    OPEN
    Title: fMRI during active GPi DBS uncovers target-specific networks
    Author(s): Brendan Santyr, Clement Chow, Jürgen Germann, Alexandre Boutet, Afis Ajala, Jianwei Qiu, Arron Loh, Ibrahim Alhashyan, Mohamad Abbass, Gavin Elias, Can Sarica, Artur Vetkas, Andrew Yang, Desmond Yeo, Suneil Kalia, Melanie Cohn, Alfonso Fasano, Andres M. Lozano
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol:
    Issue #:
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/s41531-026-01476-8
    Best OA location URL: https://www.nature.com/articles/s41531-026-01476-8_reference.pdf
    Citation Count: 0
  • The Genetic Landscape of Hereditary Spastic Paraplegia in Greece
    2025
    Summary Details
    OPEN
    Title: The Genetic Landscape of Hereditary Spastic Paraplegia in Greece
    Author(s): Georgios Koutsis, Viorica Chelban, Chrisoula Kartanou, Zoi Kontogeorgiou, Chrysoula Koniari, Nikolaos Ragazos, Charalampos Voudommatis, Kristina Zhelcheska, David S. Lynch, Reza Maroofian, Ehsan Barkhordari, Rahema Mohammad, Ioannis Zaganas, Minas Drakos, Georgia Xiromerisiou, Efthimios Dardiotis, Leonidas Stefanis, Μάριος Πάνας, Henry Houlden, Georgia Karadima
    Journal Name: Clinical Genetics
    Publisher: Wiley
    Vol: 109
    Issue #: 5
    Start Page: 837
    End Page: 846
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1111/cge.70113
    Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cge.70113
    Citation Count: 0
  • α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease
    2018
    Summary Details
    OPEN
    Title: α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease
    Author(s): Seong Su Kang, Eun Hee Ahn, Zhentao Zhang, Xia Liu, Fredric P. Manfredsson, Ivette M. Sandoval, Susov Dhakal, P. Michael Iuvone, Xuebing Cao, Keqiang Ye
    Journal Name: The EMBO Journal
    Publisher: Springer Science and Business Media LLC
    Vol: 37
    Issue #: 12
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.15252/embj.201798878
    Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.201798878
    Citation Count: 97
  • Hierarchical cluster analysis of multimodal imaging data identifies brain atrophy and cognitive patterns in Parkinson’s disease
    2020
    Summary Details
    OPEN
    Title: Hierarchical cluster analysis of multimodal imaging data identifies brain atrophy and cognitive patterns in Parkinson’s disease
    Author(s): Anna Inguanzo, Roser Sala‐Llonch, Bàrbara Segura, H. Erostarbe, Alexandra Abós, Anna Campabadal, Carme Uribe, Hugo C. Baggio, Yaroslau Compta, Marı́a José Martı́, Francesc Valldeoriola, Núria Bargalló, Carme Junqué
    Journal Name: Parkinsonism & Related Disorders
    Publisher: Elsevier BV
    Vol: 82
    Issue #:
    Start Page: 16
    End Page: 23
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1016/j.parkreldis.2020.11.010
    Best OA location URL: http://www.prd-journal.com/article/S1353802020308609/pdf
    Citation Count: 61
  • Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein
    2020
    Summary Details
    OPEN
    Title: Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein
    Author(s): Eunna Chung, Youngsil Choi, Jiae Park, Wonheum Nah, Jae-Hyung Park, Yukdong Jung, Joonno Lee, Hyunji Lee, So‐Young Park, Sun‐Young Hwang, Seongcheol Kim, Jong-Seok Lee, Dongjae Min, Jung-Hwan Jo, Shinyoung Kang, Minyong Jung, Phil Hyu Lee, H. Earl Ruley, Daewoong Jo
    Journal Name: Science Advances
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 6
    Issue #: 18
    Start Page: eaba1193
    End Page: eaba1193
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1126/sciadv.aba1193
    Best OA location URL: https://advances.sciencemag.org/content/advances/6/18/eaba1193.full.pdf
    Citation Count: 70
  • Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
    2016
    Summary Details
    OPEN
    Title: Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
    Author(s): Giambattista Guaitoli, Francesco Raimondi, Bernd K. Gilsbach, Yacob Gómez-Llorente, Egon Deyaert, Fabiana Renzi, Xianting Li, Adam Schaffner, Pravin Kumar Ankush Jagtap, Karsten Boldt, Felix von Zweydorf, Katja Gotthardt, Donald D. Lorimer, Zhenyu Yue, Alex B. Burgin, Nebojša Janjić, Michael Sattler, Wim Versées, Marius Ueffing, Iban Ubarretxena‐Belandia, Arjan Kortholt, Christian Johannes Gloeckner
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: National Academy of Sciences
    Vol: 113
    Issue #: 30
    Start Page: E4357
    End Page: 66
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1523708113
    Best OA location URL: https://www.pnas.org/content/pnas/113/30/E4357.full.pdf
    Citation Count: 155
  • Effects of Parkin on the Mitochondrial Genome in the Heart and Brain of Mitochondrial Mutator Mice
    2023
    Summary Details
    OPEN
    Title: Effects of Parkin on the Mitochondrial Genome in the Heart and Brain of Mitochondrial Mutator Mice
    Author(s): Eliezer Z. Lichter, Andrew J. Trease, Kathryn Cooper, Kelly L. Stauch, Howard S. Fox
    Journal Name: Advanced Biology
    Publisher: Wiley
    Vol: 7
    Issue #: 8
    Start Page: e2300154
    End Page: e2300154
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1002/adbi.202300154
    Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adbi.202300154
    Citation Count: 2
  • The End Is the Beginning: Parkinson’s Disease in the Light of Brain Imaging
    2017
    Summary Details
    OPEN
    Title: The End Is the Beginning: Parkinson’s Disease in the Light of Brain Imaging
    Author(s): Arianna Bellucci, Angelo Antonini, Marina Pizzi, PierFranco Spano
    Journal Name: Frontiers in Aging Neuroscience
    Publisher: Frontiers Media SA
    Vol: 9
    Issue #:
    Start Page: 330
    End Page: 330
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.3389/fnagi.2017.00330
    Best OA location URL: https://www.frontiersin.org/articles/10.3389/fnagi.2017.00330/pdf
    Citation Count: 45
  • The emerging role and therapeutic targeting of autophagy-lysosome pathway in the pathogenesis of Parkinson’s disease
    2026
    Summary Details
    OPEN
    Title: The emerging role and therapeutic targeting of autophagy-lysosome pathway in the pathogenesis of Parkinson’s disease
    Author(s): Takahiro Shimizu, Sanem Isik, Nitika Kamath, Zhenyu Yue
    Journal Name: Translational Neurodegeneration
    Publisher: Springer Science and Business Media LLC
    Vol: 15
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1186/s40035-026-00555-3
    Best OA location URL: https://link.springer.com/content/pdf/10.1186/s40035-026-00555-3.pdf
    Citation Count: 0
  • USP14 inhibition enhances Parkin-independent mitophagy in iNeurons
    2024
    Summary Details
    OPEN
    Title: USP14 inhibition enhances Parkin-independent mitophagy in iNeurons
    Author(s): Greta Bernardo, Miguel A. Prado, Anna Roshani Dashtmian, Mariavittoria Favaro, Sofia Mauri, Alice Borsetto, Elena Marchesan, João A. Paulo, Steve P. Gygi, Daniel Finley, Elena Ziviani
    Journal Name: Pharmacological Research
    Publisher: Elsevier BV
    Vol: 210
    Issue #:
    Start Page: 107484
    End Page: 107484
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1016/j.phrs.2024.107484
    Best OA location URL: https://doi.org/10.1016/j.phrs.2024.107484
    Citation Count: 10
  • Genetic evidence supports therapeutic modulation of progranulin levels in Alzheimer’s Disease
    2026
    Summary Details
    OPEN
    Title: Genetic evidence supports therapeutic modulation of progranulin levels in Alzheimer’s Disease
    Author(s): Chloe Robins, John Eicher, Jimmy Liu, Yancy Lo, Tom G. Richardson, Daniel Western, Jonathan Davitte, Carlos Cruchaga, for the Alzheimer’s Disease Neuroimaging Initiative, Umesh Kumar, Chunfang Xu
    Journal Name: Molecular Neurodegeneration Advances
    Publisher: Springer Science and Business Media LLC
    Vol: 2
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1186/s44477-025-00011-y
    Best OA location URL: https://doi.org/10.1186/s44477-025-00011-y
    Citation Count: 0
  • Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease
    2020
    Summary Details
    OPEN
    Title: Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease
    Author(s): Alexandra I. Soto‐Beasley, Ronald L. Walton, Rebecca R. Valentino, Paul W. Hook, Catherine Labbé, Michael G. Heckman, Patrick W. Johnson, Loyal A. Goff, Ryan J. Uitti, Pamela J. McLean, Wolfdieter Springer, Andrew S. McCallion, Zbigniew K. Wszołek, Owen A. Ross
    Journal Name: Parkinsonism & Related Disorders
    Publisher: Elsevier BV
    Vol: 78
    Issue #:
    Start Page: 138
    End Page: 144
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.parkreldis.2020.07.022
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7686230
    Citation Count: 19
  • Level I PD‐MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia
    2022
    Summary Details
    OPEN
    Title: Level I PD‐MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia
    Author(s): Judith A. Boel, Rob M.A. de Bie, Ben Schmand, John C. Dalrymple‐Alford, Connie Marras, Charles H. Adler, Jennifer G. Goldman, Alexander I. Tröster, David J. Burn, Irene Litvan, Gert J. Geurtsen, MDS Study Group Mild Cognitive Impairment in Parkinson's Disease
    Journal Name: Movement Disorders Clinical Practice
    Publisher: Wiley
    Vol: 9
    Issue #: 4
    Start Page: 479
    End Page: 483
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1002/mdc3.13451
    Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.13451
    Citation Count: 29
  • Induction of the Endoplasmic-Reticulum-Stress Response: MicroRNA-34a Targeting of the IRE1α-Branch
    2020
    Summary Details
    OPEN
    Title: Induction of the Endoplasmic-Reticulum-Stress Response: MicroRNA-34a Targeting of the IRE1α-Branch
    Author(s): Lena Krammes, Martin Hart, Stefanie Rheinheimer, Caroline Diener, Jennifer Menegatti, Friedrich A. Grässer, Andreas Keller, Eckart Meese
    Journal Name: Cells
    Publisher: MDPI AG
    Vol: 9
    Issue #: 6
    Start Page: 1442
    End Page: 1442
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.3390/cells9061442
    Best OA location URL: https://www.mdpi.com/2073-4409/9/6/1442/pdf?version=1592474637
    Citation Count: 22
  • Role of alpha-synuclein seed amplification assay in Parkinson’s disease clinical trials: A case of misdiagnosis
    2024
    Summary Details
    OPEN
    Title: Role of alpha-synuclein seed amplification assay in Parkinson’s disease clinical trials: A case of misdiagnosis
    Author(s): Emily Tharp, Juan De Luigi Lemus, Mya C. Schiess, Timothy M. Ellmore, Jessika Suescun, Shahnawaz Mohammad
    Journal Name: Clinical Parkinsonism & Related Disorders
    Publisher: Elsevier BV
    Vol: 11
    Issue #:
    Start Page: 100274
    End Page: 100274
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1016/j.prdoa.2024.100274
    Best OA location URL: https://doi.org/10.1016/j.prdoa.2024.100274
    Citation Count: 2
  • Metadata Concepts for Advancing the Use of Digital Health Technologies in Clinical Research
    2019
    Summary Details
    OPEN
    Title: Metadata Concepts for Advancing the Use of Digital Health Technologies in Clinical Research
    Author(s): Reham Badawy, Farhan Hameed, Lauren Bataille, Max A. Little, Kasper Claes, Suchi Saria, Jesse M. Cedarbaum, Diane Stephenson, Jon Neville, Walter Maetzler, Alberto J. Espay, Bastiaan R. Bloem, Tanya Simuni, Daniel R. Karlin
    Journal Name: Digital Biomarkers
    Publisher: S. Karger AG
    Vol: 3
    Issue #: 3
    Start Page: 116
    End Page: 132
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1159/000502951
    Best OA location URL: https://www.karger.com/Article/Pdf/502951
    Citation Count: 46
  • Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates
    2025
    Summary Details
    OPEN
    Title: Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates
    Author(s): Fei Wang, Victor Banerjee, Carla Barria, Santiago Ramírez, Tyler Allison, Damian Gorski, Haley Evans, Quynh Nguyen, Danielle Harrison, Rabab Al‐Lahham, Nicole De Gregorio, Michelle Pinho, Sanne S. Kaalund, Jonas Folke, Susana Aznar, Luis Concha‐Marambio, Mohd Ishtikhar, Venkata Mallampalli, Sandra Pritzkow, Shahnawaz Mohammad, Matthew L. Baker, Irina I. Serysheva, Claudio Soto
    Journal Name: Nature Communications
    Publisher: Springer Science and Business Media LLC
    Vol: 16
    Issue #: 1
    Start Page: 11266
    End Page: 11266
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/s41467-025-66146-4
    Best OA location URL: https://www.nature.com/articles/s41467-025-66146-4_reference.pdf
    Citation Count: 9
  • Discordance Between Balance Ability and Perception Is Associated With Falls in Parkinson’s Disease: A Coordinated Analysis
    2024
    Summary Details
    OPEN
    Title: Discordance Between Balance Ability and Perception Is Associated With Falls in Parkinson’s Disease: A Coordinated Analysis
    Author(s): Jason K. Longhurst, Andrew Hooyman, Merrill R. Landers, Martina Mancini, Erika Franzén, Breiffni Leavy, Hanna Johansson, Daniel S. Peterson
    Journal Name: Neurorehabilitation and Neural Repair
    Publisher: SAGE Publications
    Vol: 39
    Issue #: 2
    Start Page: 114
    End Page: 125
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1177/15459683241300456
    Best OA location URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC11850210/pdf/nihms-2033435.pdf
    Citation Count: 10
  • Central Hypoventilation in Progressive Supranuclear Palsy
    2016
    Summary Details
    OPEN
    Title: Central Hypoventilation in Progressive Supranuclear Palsy
    Author(s): Kory S. Herrick, Randy Woltjer, Thao Pham, Megan Chalupsky, Amie Hiller
    Journal Name: Movement Disorders Clinical Practice
    Publisher: Wiley
    Vol: 4
    Issue #: 1
    Start Page: 42
    End Page: 45
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1002/mdc3.12348
    Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12348
    Citation Count: 6
  • Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals
    2016
    Summary Details
    OPEN
    Title: Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals
    Author(s): Clemens Schroeder, Min Tae M Park, Jürgen Germann, M. Mallar Chakravarty, Lars Michels, Spyros Kollias, Sara L. Kroll, Alfred Buck, Valérie Treyer, Egemen Savaskan, Paul G. Unschuld, Roger M. Nitsch, Andrea M. Kälin, Christoph Höck, Anton Gietl, Sandra E. Leh
    Journal Name: European Journal of Neuroscience
    Publisher: Wiley
    Vol: 45
    Issue #: 10
    Start Page: 1241
    End Page: 1251
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1111/ejn.13408
    Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejn.13408
    Citation Count: 9
  • Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in mice
    2016
    Summary Details
    OPEN
    Title: Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in mice
    Author(s): Siv Vingill, David Brockelt, Camille Lancelin, Lars Tatenhorst, Guergana Dontcheva, Christian Preisinger, Nicola Schwedhelm‐Domeyer, Sabitha Joseph, Mišo Mitkovski, Sandra Goebbels, Klaus‐Armin Nave, Jörg B. Schulz, Till Marquardt, Paul Lingor, Judith Stegmüller
    Journal Name: The EMBO Journal
    Publisher: Springer Science and Business Media LLC
    Vol: 35
    Issue #: 18
    Start Page: 2008
    End Page: 2025
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.15252/embj.201593585
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5282834
    Citation Count: 71
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