101 - 150 of 6295 Results
Title
Year
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OPENTitle: The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor SignalingJournal Name: PLoS ONEPublisher: Public Library of Science (PLoS)Vol: 7Issue #: 6Start Page: e39132End Page: e39132Publication Date:Open Access(OA) Status: OPENLicense: cc0DOI - Digital Object Identifier: 10.1371/journal.pone.0039132Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039132&type=printableCitation Count: 205
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OPENTitle: Generation of human midbrain organoids from induced pluripotent stem cellsJournal Name: MNI Open ResearchPublisher: F1000 Research LtdVol: 3Issue #:Start Page: 1End Page: 1Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.12688/mniopenres.12816.1Best OA location URL: https://mniopenresearch.org/articles/3-1/v1/pdfCitation Count: 12
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OPENTitle: Decision making in frontotemporal dementia: neuropsychological and neuroimaging assessmentsJournal Name: Frontiers in NeurosciencePublisher: Frontiers Media SAVol: 19Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnins.2025.1632054Best OA location URL: https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1632054/pdfCitation Count: 0
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OPENTitle: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunitiesJournal Name: The American Journal of Human GeneticsPublisher: Elsevier BVVol: 112Issue #: 9Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.ajhg.2025.07.014Best OA location URL: https://www.cell.com/ajhg/pdf/S0002-9297(25)00284-8.pdfCitation Count: 0
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OPENTitle: Harmonization of CSF and imaging biomarkers in Alzheimer's disease: Need and practical applications for genetics studies and preclinical classificationJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 190Issue #:Start Page: 106373End Page: 106373Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nbd.2023.106373Best OA location URL: https://doi.org/10.1016/j.nbd.2023.106373Citation Count: 13
- Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases2025OPENTitle: Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseasesJournal Name: Frontiers in ImmunologyPublisher: Frontiers Media SAVol: 16Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fimmu.2025.1599303Best OA location URL: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1599303/pdfCitation Count: 0
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OPENTitle: The neuro-toxin MPTP does not prevent reproduction in marmosetsJournal Name: MNI Open ResearchPublisher: F1000 Research LtdVol: 3Issue #:Start Page: 2End Page: 2Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.12688/mniopenres.12818.1Best OA location URL: https://mniopenresearch.org/articles/3-2/v1/pdfCitation Count: 0
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OPENTitle: An unusual presentation of Huntington’s disease-like syndrome in a patient with Xeroderma pigmentosum type F: Case report and review of the literatureJournal Name: Clinical Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 12Issue #:Start Page: 100340End Page: 100340Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.prdoa.2025.100340Best OA location URL: https://doi.org/10.1016/j.prdoa.2025.100340Citation Count: 0
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OPENTitle: a-synuclein PET Imaging: From Clinical Utility in Multiple System Atrophy to the Possible Diagnosis of Parkinson’s DiseaseJournal Name: CellsPublisher: MDPI AGVol: 14Issue #: 11Start Page: 834End Page: 834Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/cells14110834Best OA location URL: https://www.mdpi.com/2073-4409/14/11/834/pdf?version=1748956205Citation Count: 0
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OPENTitle: Increasing the use of mobile technology–derived endpoints in clinical trialsJournal Name: Clinical TrialsPublisher: SAGE PublicationsVol: 15Issue #: 3Start Page: 313End Page: 315Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1177/1740774518755393Best OA location URL: https://doi.org/10.1177/1740774518755393Citation Count: 23
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OPENTitle: Higher Frequency of Certain Cancers inLRRK2G2019S Mutation Carriers With Parkinson DiseaseJournal Name: JAMA NeurologyPublisher: American Medical Association (AMA)Vol: 72Issue #: 1Start Page: 58End Page: 58Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1001/jamaneurol.2014.1973Best OA location URL: http://doi.org/10.1001/jamaneurol.2014.1973Citation Count: 91
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OPENTitle: Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body diseaseJournal Name: AutophagyPublisher: Informa UK LimitedVol: 14Issue #: 8Start Page: 1404End Page: 1418Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/15548627.2018.1461294Best OA location URL: https://www.tandfonline.com/doi/pdf/10.1080/15548627.2018.1461294?needAccess=trueCitation Count: 121
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OPENTitle: Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 3Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/srep01393Best OA location URL: https://www.nature.com/articles/srep01393.pdfCitation Count: 150
- Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo2014OPENTitle: Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivoJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 137Issue #: 5Start Page: 1496End Page: 1513Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/awu057Best OA location URL: https://academic.oup.com/brain/article-pdf/137/5/1496/11140606/awu057.pdfCitation Count: 220
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OPENTitle: GFAP mutations, age at onset, and clinical subtypes in Alexander diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 77Issue #: 13Start Page: 1287End Page: 1294Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e3182309f72Best OA location URL: https://n.neurology.org/content/neurology/77/13/1287.full.pdfCitation Count: 230
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OPENTitle: Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 VectorsJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 18Issue #: 8Start Page: 1490End Page: 1495Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/mt.2010.114Best OA location URL: http://www.cell.com/article/S1525001616310991/pdfCitation Count: 80
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OPENTitle: Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative diseaseJournal Name: Journal of Comparative NeurologyPublisher: WileyVol: 515Issue #: 3Start Page: 269End Page: 294Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/cne.22040Best OA location URL: http://doi.org/10.1002/cne.22040Citation Count: 55
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OPENTitle: LRRK2 levels in immune cells are increased in Parkinson’s diseaseJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 3Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-017-0010-8Best OA location URL: https://doi.org/10.1038/s41531-017-0010-8Citation Count: 237
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OPENTitle: Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagyJournal Name: Nature CommunicationsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41467-017-01609-xBest OA location URL: https://doi.org/10.1038/s41467-017-01609-xCitation Count: 125
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OPENTitle: Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 104Issue #: 47Start Page: 18754End Page: 18759Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0704908104Best OA location URL: http://doi.org/10.1073/pnas.0704908104Citation Count: 416
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OPENTitle: Altered Pharyngeal Muscles in Parkinson DiseaseJournal Name: Journal of Neuropathology & Experimental NeurologyPublisher: Oxford University Press (OUP)Vol: 71Issue #: 6Start Page: 520End Page: 530Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1097/nen.0b013e318258381bBest OA location URL: https://academic.oup.com/jnen/article-pdf/71/6/520/9562114/71-6-520.pdfCitation Count: 136
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OPENTitle: GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark miceJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-23795-4Best OA location URL: https://www.nature.com/articles/s41598-018-23795-4.pdfCitation Count: 39
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OPENTitle: Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer’s disease pathologiesJournal Name: Journal of NeurochemistryPublisher: WileyVol: 109Issue #: 2Start Page: 623End Page: 630Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1471-4159.2009.05996.xBest OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.05996.xCitation Count: 140
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OPENTitle: In vitro high affinity α‐synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain1Journal Name: Journal of NeurochemistryPublisher: WileyVol: 105Issue #: 4Start Page: 1428End Page: 1437Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1471-4159.2008.05245.xBest OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2008.05245.xCitation Count: 92
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OPENTitle: Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's diseaseJournal Name: Nature GeneticsPublisher: Springer Science and Business Media LLCVol: 42Issue #: 9Start Page: 781End Page: 785Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/ng.642Best OA location URL: http://hdl.handle.net/20.500.11820/b0e35720-bc0d-43af-818b-6597947a050fCitation Count: 754
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OPENTitle: Noninvasive optical inhibition with a red-shifted microbial rhodopsinJournal Name: Nature NeurosciencePublisher: Springer Science and Business Media LLCVol: 17Issue #: 8Start Page: 1123End Page: 1129Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/nn.3752Best OA location URL: http://hdl.handle.net/1721.1/98648Citation Count: 542
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OPENTitle: Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson DiseaseJournal Name: JAMA NeurologyPublisher: American Medical Association (AMA)Vol: 70Issue #: 2Start Page: 183End Page: 183Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1001/jamaneurol.2013.646Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4574905Citation Count: 386
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OPENTitle: Interocular Asymmetry of Foveal Thickness in Parkinson DiseaseJournal Name: Journal of OphthalmologyPublisher: WileyVol: 2012Issue #:Start Page: 1End Page: 6Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1155/2012/728457Best OA location URL: https://downloads.hindawi.com/journals/joph/2012/728457.pdfCitation Count: 74
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OPENTitle: Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylasesJournal Name: Journal of Enzyme Inhibition and Medicinal ChemistryPublisher: Informa UK LimitedVol: 31Issue #: sup2Start Page: 148End Page: 161Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/14756366.2016.1193734Best OA location URL: https://www.tandfonline.com/doi/pdf/10.1080/14756366.2016.1193734?needAccess=trueCitation Count: 12
- Different PD-MCI criteria and risk of dementia in Parkinson’s disease: 4-year longitudinal study2016OPENTitle: Different PD-MCI criteria and risk of dementia in Parkinson’s disease: 4-year longitudinal studyJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 2Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/npjparkd.2015.27Best OA location URL: https://www.nature.com/articles/npjparkd201527.pdfCitation Count: 71
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OPENTitle: Bayesian latent time joint mixed‐effects model of progression in the Alzheimer's Disease Neuroimaging InitiativeJournal Name: Alzheimer's & Dementia: Diagnosis, Assessment & Disease MonitoringPublisher: WileyVol: 10Issue #: 1Start Page: 657End Page: 668Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.dadm.2018.07.008Best OA location URL: https://escholarship.org/uc/item/6cq9g6b3Citation Count: 23
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OPENTitle: Microglial responses to dopamine in a cell culture model of Parkinson's diseaseJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 30Issue #: 11Start Page: 1805End Page: 1817Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2008.01.001Citation Count: 109
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OPENTitle: Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass SpectrometryJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-saDOI - Digital Object Identifier: 10.1038/srep05797Best OA location URL: https://doi.org/10.1038/srep05797Citation Count: 155
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OPENTitle: Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microgliaJournal Name: Journal of NeuroinflammationPublisher: Springer Science and Business Media LLCVol: 11Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12974-014-0164-9Best OA location URL: https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-014-0164-9Citation Count: 31
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OPENTitle: GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synucleinJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 105Issue #: 31Start Page: 10907End Page: 10912Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0802437105Best OA location URL: https://www.pnas.org/content/pnas/105/31/10907.full.pdfCitation Count: 260
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OPENTitle: Mechanism of parkin activation by PINK1Journal Name: NaturePublisher: Springer Science and Business Media LLCVol: 559Issue #: 7714Start Page: 410End Page: 414Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41586-018-0224-xBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6071873Citation Count: 326
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OPENTitle: Impaired dopamine release and synaptic plasticity in the striatum of PINK1 -deficient miceJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 104Issue #: 27Start Page: 11441End Page: 11446Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0702717104Best OA location URL: https://www.pnas.org/doi/pdf/10.1073/pnas.0702717104Citation Count: 523
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OPENTitle: Habitual intake of dietary flavonoids and risk of Parkinson diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 78Issue #: 15Start Page: 1138End Page: 1145Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e31824f7fc4Best OA location URL: https://n.neurology.org/content/neurology/78/15/1138.full.pdfCitation Count: 315
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OPENTitle: Plasticity in Early Alzheimer DiseaseJournal Name: Topics in Geriatric RehabilitationPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 27Issue #: 4Start Page: 257End Page: 267Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1097/tgr.0b013e31821e588eBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3419487Citation Count: 40
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OPENTitle: Sex disparities in health and health care utilization after Parkinson diagnosis: Rethinking PD associated disabilityJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 48Issue #:Start Page: 45End Page: 50Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2017.12.012Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6559800Citation Count: 22
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OPENTitle: Sex-specific genetic predictors of Alzheimer’s disease biomarkersJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 136Issue #: 6Start Page: 857End Page: 872Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-018-1881-4Citation Count: 106
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OPENTitle: Involvement of Perineuronal and Perisynaptic Extracellular Matrix in Alzheimer's Disease NeuropathologyJournal Name: Brain PathologyPublisher: WileyVol: 22Issue #: 4Start Page: 547End Page: 561Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1750-3639.2011.00557.xBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3639011Citation Count: 146
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OPENTitle: Testing a longitudinal compensation model in premanifest Huntington’s diseaseJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 141Issue #: 7Start Page: 2156End Page: 2166Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1093/brain/awy122Best OA location URL: https://academic.oup.com/brain/article-pdf/141/7/2156/25094716/awy122.pdfCitation Count: 45
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OPENTitle: Inosine to Increase Serum and Cerebrospinal Fluid Urate in Parkinson DiseaseJournal Name: JAMA NeurologyPublisher: American Medical Association (AMA)Vol: 71Issue #: 2Start Page: 141End Page: 141Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1001/jamaneurol.2013.5528Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3940333Citation Count: 225
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OPENTitle: Identifying blood-brain-barrier selective single-chain antibody fragmentsJournal Name: Biotechnology JournalPublisher: WileyVol: 9Issue #: 5Start Page: 664End Page: 674Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/biot.201300550Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4073886Citation Count: 23
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OPENTitle: Incidental Lewy body disease: Clinical comparison to a control cohortJournal Name: Movement DisordersPublisher: WileyVol: 25Issue #: 5Start Page: 642End Page: 646Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.22971Best OA location URL: http://doi.org/10.1002/mds.22971Citation Count: 135
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OPENTitle: An early and late peak in microglial activation in Alzheimer’s disease trajectoryJournal Name: BrainPublisher: Oxford University Press (OUP)Vol:Issue #:Start Page: aww349End Page: aww349Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/aww349Best OA location URL: https://academic.oup.com/brain/article-pdf/140/3/792/24174911/aww349.pdfCitation Count: 382
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OPENTitle: Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer‐induced AMPA glutamate receptor signaling deficitsJournal Name: European Journal of NeurosciencePublisher: WileyVol: 39Issue #: 7Start Page: 1214End Page: 1224Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/ejn.12507Citation Count: 119
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OPENTitle: Correlation of Amyloid PET Ligand Florbetapir F 18 Binding With Aβ Aggregation and Neuritic Plaque Deposition in Postmortem Brain TissueJournal Name: Alzheimer Disease & Associated DisordersPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 26Issue #: 1Start Page: 8End Page: 16Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1097/wad.0b013e31821300bcBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3286131Citation Count: 128
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OPENTitle: Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegansJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep34477Best OA location URL: https://doi.org/10.1038/srep34477Citation Count: 428