101 - 150 of 6230 Results
Title
Year
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OPENTitle: Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulatorsJournal Name: Molecular PsychiatryPublisher: Springer Science and Business Media LLCVol: 25Issue #: 11Start Page: 2786End Page: 2799Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41380-018-0206-2Best OA location URL: https://www.nature.com/articles/s41380-018-0206-2.pdfCitation Count: 46
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OPENTitle: Alzheimer Research Forum Live Discussion: Mice on Trial? Issues in the Design of Drug StudiesJournal Name: Journal of Alzheimer's DiseasePublisher: SAGE PublicationsVol: 16Issue #: 1Start Page: 197End Page: 205Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jad-2009-0961Best OA location URL: https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad00961?id=journal-of-alzheimers-disease%2Fjad00961Citation Count: 1
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OPENTitle: The Impact of COVID‐19 on Access to Parkinson's Disease MedicationJournal Name: Movement DisordersPublisher: WileyVol: 35Issue #: 12Start Page: 2129End Page: 2133Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1002/mds.28293Best OA location URL: https://onlinelibrary.wiley.com/doi/pdf/10.1002/mds.28293Citation Count: 44
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OPENTitle: Mitochondrial Function in Hereditary Spastic Paraplegia: Deficits in SPG7 but Not SPAST Patient-Derived Stem CellsJournal Name: Frontiers in NeurosciencePublisher: Frontiers Media SAVol: 14Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnins.2020.00820Best OA location URL: https://www.frontiersin.org/articles/10.3389/fnins.2020.00820/pdfCitation Count: 25
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OPENTitle: Advances in Therapeutic Options for Gait and Balance in Parkinson’s DiseaseJournal Name: US NeurologyPublisher: Touch Medical Media, Ltd.Vol: 07Issue #: 02Start Page: 100End Page: 100Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.17925/usn.2011.07.02.100Best OA location URL: http://www.touchneurology.com/wp-content/uploads/sites/3/2015/07/private_articles_10210_pdf_chou.pdfCitation Count: 20
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OPENTitle: Cerebral blood flow in Alzheimer’s diseaseJournal Name: Vascular Health and Risk ManagementPublisher: Informa UK LimitedVol:Issue #:Start Page: 599End Page: 599Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.2147/vhrm.s34874Best OA location URL: https://www.dovepress.com/getfile.php?fileID=14292Citation Count: 187
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OPENTitle: Neuroprotective activities of regulatory T cellsJournal Name: Trends in Molecular MedicinePublisher: Elsevier BVVol: 17Issue #: 12Start Page: 687End Page: 688Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.molmed.2011.08.005Best OA location URL: http://doi.org/10.1016/j.molmed.2011.08.005Citation Count: 51
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OPENTitle: Recruitment of patients with de novo Parkinson disease: successful strategies in a randomized exercise clinical trialJournal Name: TrialsPublisher: Springer Science and Business Media LLCVol: 19Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13063-018-2958-zBest OA location URL: https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-018-2958-zCitation Count: 11
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OPENTitle: Lentiviral Overexpression of GRK6 Alleviates l -Dopa–Induced Dyskinesia in Experimental Parkinson’s DiseaseJournal Name: Science Translational MedicinePublisher: American Association for the Advancement of Science (AAAS)Vol: 2Issue #: 28Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1126/scitranslmed.3000664Best OA location URL: http://doi.org/10.1126/scitranslmed.3000664Citation Count: 135
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OPENTitle: Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s DiseaseJournal Name: Science Translational MedicinePublisher: American Association for the Advancement of Science (AAAS)Vol: 4Issue #: 141Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1126/scitranslmed.3003985Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3462009Citation Count: 490
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OPENTitle: Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutationJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-017-01587-6Best OA location URL: https://www.nature.com/articles/s41598-017-01587-6.pdfCitation Count: 37
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OPENTitle: Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep40263Best OA location URL: https://www.nature.com/articles/srep40263.pdfCitation Count: 54
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OPENTitle: Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic CellsJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep41117Best OA location URL: https://www.nature.com/articles/srep41117.pdfCitation Count: 8
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OPENTitle: Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-017-04254-yBest OA location URL: https://www.nature.com/articles/s41598-017-04254-y.pdfCitation Count: 25
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OPENTitle: The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactionsJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-017-05760-9Best OA location URL: https://www.nature.com/articles/s41598-017-05760-9.pdfCitation Count: 64
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OPENTitle: Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-33921-xBest OA location URL: https://www.nature.com/articles/s41598-018-33921-x.pdfCitation Count: 102
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OPENTitle: Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-017-07181-0Best OA location URL: https://www.nature.com/articles/s41598-017-07181-0.pdfCitation Count: 113
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OPENTitle: Unraveling connectivity changes due to dopaminergic therapy in chronically treated Parkinson’s disease patientsJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-31988-0Best OA location URL: https://www.nature.com/articles/s41598-018-31988-0.pdfCitation Count: 21
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OPENTitle: Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progressionJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-35130-yBest OA location URL: https://www.nature.com/articles/s41598-018-35130-y.pdfCitation Count: 46
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OPENTitle: Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxinJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-30561-zBest OA location URL: https://www.nature.com/articles/s41598-018-30561-z.pdfCitation Count: 38
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OPENTitle: Computational affinity maturation of camelid single-domain intrabodies against the nonamyloid component of alpha-synucleinJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-35464-7Best OA location URL: https://www.nature.com/articles/s41598-018-35464-7.pdfCitation Count: 40
- Benefits of pallidal stimulation in dystonia are linked to cerebellar volume and cortical inhibition2018OPENTitle: Benefits of pallidal stimulation in dystonia are linked to cerebellar volume and cortical inhibitionJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-34880-zBest OA location URL: https://www.nature.com/articles/s41598-018-34880-z.pdfCitation Count: 14
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OPENTitle: Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblastsJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-19865-2Best OA location URL: https://www.nature.com/articles/s41598-018-19865-2.pdfCitation Count: 8
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OPENTitle: Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson’s disease/dementia with Lewy bodiesJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-35729-1Best OA location URL: https://www.nature.com/articles/s41598-018-35729-1.pdfCitation Count: 24
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OPENTitle: GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark miceJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-23795-4Best OA location URL: https://www.nature.com/articles/s41598-018-23795-4.pdfCitation Count: 39
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OPENTitle: Model-based and Model-free Machine Learning Techniques for Diagnostic Prediction and Classification of Clinical Outcomes in Parkinson’s DiseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-24783-4Best OA location URL: https://www.nature.com/articles/s41598-018-24783-4.pdfCitation Count: 171
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OPENTitle: Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patientsJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep30793Best OA location URL: https://www.nature.com/articles/srep30793.pdfCitation Count: 34
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OPENTitle: Integration of transcriptomic and genomic data suggests candidate mechanisms for APOE4-mediated pathogenic action in Alzheimer’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep32583Best OA location URL: https://www.nature.com/articles/srep32583.pdfCitation Count: 22
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OPENTitle: Inhibitor treatment of peripheral mononuclear cells from Parkinson’s disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarkerJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep31391Best OA location URL: https://www.nature.com/articles/srep31391.pdfCitation Count: 260
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OPENTitle: Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug deliveryJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep31732Best OA location URL: https://www.nature.com/articles/srep31732.pdfCitation Count: 52
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OPENTitle: Structural insights into Parkin substrate lysine targeting from minimal Miro substratesJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep33019Best OA location URL: https://www.nature.com/articles/srep33019.pdfCitation Count: 53
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OPENTitle: mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1Journal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep35106Best OA location URL: https://www.nature.com/articles/srep35106.pdfCitation Count: 73
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OPENTitle: Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cellsJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-017-10501-zBest OA location URL: https://www.nature.com/articles/s41598-017-10501-z.pdfCitation Count: 97
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OPENTitle: Genetic variants affecting equivalent protein family positions reflect human diversityJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-017-12971-7Best OA location URL: https://www.nature.com/articles/s41598-017-12971-7.pdfCitation Count: 10
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OPENTitle: Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stressJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-017-02339-2Best OA location URL: https://www.nature.com/articles/s41598-017-02339-2.pdfCitation Count: 41
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OPENTitle: Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 3Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/srep01393Best OA location URL: https://www.nature.com/articles/srep01393.pdfCitation Count: 150
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OPENTitle: A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expressionJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 5Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep16615Best OA location URL: https://www.nature.com/articles/srep16615.pdfCitation Count: 25
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OPENTitle: n-3 PUFA supplementation benefits microglial responses to myelin pathologyJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-saDOI - Digital Object Identifier: 10.1038/srep07458Best OA location URL: https://www.nature.com/articles/srep07458.pdfCitation Count: 130
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OPENTitle: Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injuryJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep21709Best OA location URL: https://www.nature.com/articles/srep21709.pdfCitation Count: 91
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OPENTitle: Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signalingJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 5Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep14125Best OA location URL: https://www.nature.com/articles/srep14125.pdfCitation Count: 38
- GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 12012OPENTitle: GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1Journal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 2Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/srep00695Best OA location URL: https://www.nature.com/articles/srep00695.pdfCitation Count: 12
- α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson’s Disease2010OPENTitle: α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson’s DiseaseJournal Name: NeuroepidemiologyPublisher: S. Karger AGVol: 35Issue #: 3Start Page: 191End Page: 195Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1159/000315157Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/2945263Citation Count: 62
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OPENTitle: Familial Aggregation of Cranial Tremor in Familial Essential TremorJournal Name: NeuroepidemiologyPublisher: S. Karger AGVol: 41Issue #: 1Start Page: 48End Page: 53Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1159/000348553Best OA location URL: https://karger.com/ned/article-pdf/41/1/48/3154672/000348553.pdfCitation Count: 6
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OPENTitle: Rare variants in LRRK1 and Parkinson's diseaseJournal Name: neurogeneticsPublisher: Springer Science and Business Media LLCVol: 15Issue #: 1Start Page: 49End Page: 57Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s10048-013-0383-8Best OA location URL: https://link.springer.com/content/pdf/10.1007/s10048-013-0383-8.pdfCitation Count: 30
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OPENTitle: Familial Aggregation and Co-Aggregation of Essential Tremor and Parkinson's DiseaseJournal Name: NeuroepidemiologyPublisher: S. Karger AGVol: 46Issue #: 1Start Page: 31End Page: 36Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1159/000442021Best OA location URL: https://europepmc.org/articles/pmc4764067?pdf=renderCitation Count: 18
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OPENTitle: Putamen–midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseasesJournal Name: NeuroImage: ClinicalPublisher: Elsevier BVVol: 8Issue #:Start Page: 554End Page: 559Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nicl.2015.06.001Best OA location URL: https://www.sciencedirect.com/science/article/pii/S2213158215001072/pdfft?md5=850ee09b40e3f024731a495688d08f9d&pid=1-s2.0-S2213158215001072-main.pdfCitation Count: 23
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OPENTitle: Increases in frontostriatal connectivity are associated with response to dorsomedial repetitive transcranial magnetic stimulation in refractory binge/purge behaviorsJournal Name: NeuroImage: ClinicalPublisher: Elsevier BVVol: 8Issue #:Start Page: 611End Page: 618Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nicl.2015.06.008Best OA location URL: https://doi.org/10.1016/j.nicl.2015.06.008Citation Count: 67
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OPENTitle: Automatic segmentation of the hippocampus for preterm neonates from early-in-life to term-equivalent ageJournal Name: NeuroImage: ClinicalPublisher: Elsevier BVVol: 9Issue #:Start Page: 176End Page: 193Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nicl.2015.07.019Best OA location URL: https://doi.org/10.1016/j.nicl.2015.07.019Citation Count: 38
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OPENTitle: Use of a self-rating scale of the nature and severity of symptoms in Parkinson’s Disease (PRO-PD): Correlation with quality of life and existing scales of disease severityJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 3Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-017-0021-5Best OA location URL: https://www.nature.com/articles/s41531-017-0021-5.pdfCitation Count: 41
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OPENTitle: Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activityJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-018-0049-1Best OA location URL: https://www.nature.com/articles/s41531-018-0049-1.pdfCitation Count: 69