1951 - 2000 of 8571 Results
Title
Year
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OPENTitle: Urinary proteome profiling for stratifying patients with familial Parkinson’s diseaseJournal Name: EMBO Molecular MedicinePublisher: Springer Science and Business Media LLCVol: 13Issue #: 3Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.15252/emmm.202013257Best OA location URL: https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.202013257Citation Count: 128
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RESTRICTEDTitle: Detection of Proteolytic Signatures for Parkinson's DiseaseJournal Name: Future NeurologyPublisher: Informa UK LimitedVol: 11Issue #: 1Start Page: 15End Page: 32Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.2217/fnl.16.3Citation Count: 0
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OPENTitle: Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease featuresJournal Name: The EMBO JournalPublisher: Springer Science and Business Media LLCVol: 40Issue #: 3Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.15252/embj.2020105537Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2020105537Citation Count: 55
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OPENTitle: Epidural Spinal Cord Stimulation Improves Motor Function in Rats With Chemically Induced ParkinsonismJournal Name: Neurorehabilitation and Neural RepairPublisher: SAGE PublicationsVol: 33Issue #: 12Start Page: 1029End Page: 1039Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1177/1545968319876891Best OA location URL: https://journals.sagepub.com/doi/pdf/10.1177/1545968319876891Citation Count: 11
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OPENTitle: Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson'sJournal Name: Annals of NeurologyPublisher: WileyVol: 80Issue #: 5Start Page: 674End Page: 685Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1002/ana.24781Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.24781Citation Count: 246
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OPENTitle: Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic EfficacyJournal Name: ACS Pharmacology & Translational SciencePublisher: American Chemical Society (ACS)Vol: 4Issue #: 4Start Page: 1306End Page: 1321Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/acsptsci.0c00162Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8369681Citation Count: 24
- Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation2018OPENTitle: Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylationJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 13Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13024-018-0235-yBest OA location URL: https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-018-0235-yCitation Count: 106
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RESTRICTEDTitle: Carepartner Communication on Parkinson Disease Psychosis (4116)Journal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 94Issue #: 15_supplementStart Page:End Page:Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1212/wnl.94.15_supplement.4116Citation Count: 0
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OPENTitle: Detecting the symptoms of Parkinson’s disease with non-standard videoJournal Name: Journal of NeuroEngineering and RehabilitationPublisher: Springer Science and Business Media LLCVol: 21Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12984-024-01362-5Best OA location URL: https://link.springer.com/content/pdf/10.1186/s12984-024-01362-5.pdfCitation Count: 1
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OPENTitle: The transition between turning and sitting in patients with Parkinson's disease: A wearable device detects an unexpected sequence of eventsJournal Name: Gait & PosturePublisher: Elsevier BVVol: 67Issue #:Start Page: 224End Page: 229Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.gaitpost.2018.10.018Citation Count: 32
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OPENTitle: α-Synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells: an in vitro proof of concept studyJournal Name: Brain CommunicationsPublisher: Oxford University Press (OUP)Vol: 5Issue #: 6Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1093/braincomms/fcad285Best OA location URL: https://academic.oup.com/braincomms/advance-article-pdf/doi/10.1093/braincomms/fcad285/52454987/fcad285.pdfCitation Count: 8
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OPENTitle: Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activityJournal Name: Disease Models & MechanismsPublisher: The Company of BiologistsVol: 9Issue #: 11Start Page: 1295End Page: 1305Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1242/dmm.025684Best OA location URL: http://dmm.biologists.org/content/dmm/9/11/1295.full.pdfCitation Count: 61
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OPENTitle: Feasibility, Safety, and Compliance in a Randomized Controlled Trial of Physical Therapy for Parkinson's DiseaseJournal Name: Parkinson's DiseasePublisher: WileyVol: 2012Issue #:Start Page: 1End Page: 8Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1155/2012/795294Best OA location URL: https://downloads.hindawi.com/journals/pd/2012/795294.pdfCitation Count: 32
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OPENTitle: Validation of Parkinson's Disease Ascertainment in the Veterans Administration Electronic Medical RecordJournal Name: Movement DisordersPublisher: WileyVol: 40Issue #: 2Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/mds.30075Best OA location URL: https://doi.org/10.1002/mds.30075Citation Count: 2
- Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK22021OPENTitle: Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2Journal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 118Issue #: 23Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1073/pnas.2100844118Best OA location URL: https://pnas.org/doi/pdf/10.1073/pnas.2100844118Citation Count: 66
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OPENTitle: Regulation of expression quantitative trait loci by SVA retrotransposons within the major histocompatibility complexJournal Name: Experimental Biology and MedicinePublisher: Frontiers Media SAVol:Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1177/15353702231209411Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/10903234Citation Count: 9
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OPENTitle: An interpretable machine learning‐based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain agingJournal Name: Aging CellPublisher: WileyVol: 23Issue #: 9Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1111/acel.14230Best OA location URL: https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.14230Citation Count: 4
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OPENTitle: Increased odds of bladder and bowel symptoms in early Parkinson's diseaseJournal Name: Neurourology and UrodynamicsPublisher: WileyVol: 37Issue #: 4Start Page: 1344End Page: 1348Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/nau.23443Citation Count: 10
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OPENTitle: Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's diseaseJournal Name: Neuroscience LettersPublisher: Elsevier BVVol: 480Issue #: 1Start Page: 78End Page: 82Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neulet.2010.06.009Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/2943649Citation Count: 199
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OPENTitle: Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particlesJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 12Issue #: 8Start Page: e0181844End Page: e0181844Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0181844Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181844&type=printableCitation Count: 31
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OPENTitle: Distribution of Parkinson’s disease associated RAB39B in mouse brain tissueJournal Name: Molecular BrainPublisher: Springer Science and Business Media LLCVol: 13Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13041-020-00584-7Best OA location URL: https://molecularbrain.biomedcentral.com/track/pdf/10.1186/s13041-020-00584-7Citation Count: 9
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OPENTitle: Predictors of cognitive impairment in primary age-related tauopathy: an autopsy studyJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 9Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-021-01233-3Best OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-021-01233-3Citation Count: 56
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OPENTitle: Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling CascadeJournal Name: Cell Chemical BiologyPublisher: Elsevier BVVol: 28Issue #: 1Start Page: 14End Page: 25.e9Publication Date:Open Access(OA) Status: OPENLicense: other-oaDOI - Digital Object Identifier: 10.1016/j.chembiol.2020.10.008Best OA location URL: http://www.cell.com/article/S2451945620304244/pdfCitation Count: 17
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OPENTitle: Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasisJournal Name: The EMBO JournalPublisher: Springer Science and Business Media LLCVol: 41Issue #: 2Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific, author manuscriptDOI - Digital Object Identifier: 10.15252/embj.2020105531Best OA location URL: http://urn.fi/urn:nbn:fi-fe202301316706Citation Count: 23
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OPENTitle: How storage post sampling influences the stability of sebum when used for mass spectrometry metabolomics analysis?Journal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 14Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41598-024-71598-7Best OA location URL: https://www.nature.com/articles/s41598-024-71598-7.pdfCitation Count: 3
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OPENTitle: N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholineJournal Name: eLifePublisher: eLife Sciences Publications, LtdVol: 13Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.7554/elife.97228Best OA location URL: https://cdn.elifesciences.org/articles/97228/elife-97228-v1.pdfCitation Count: 2
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OPENTitle: Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson's diseaseJournal Name: Environmental Science: Processes & ImpactsPublisher: Royal Society of Chemistry (RSC)Vol: 22Issue #: 3Start Page: 543End Page: 554Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1039/c9em00578aBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7941732Citation Count: 49
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OPENTitle: Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal MitochondriaJournal Name: Frontiers in Cellular NeurosciencePublisher: Frontiers Media SAVol: 16Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fncel.2022.852245Best OA location URL: https://doi.org/10.3389/fncel.2022.852245Citation Count: 5
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OPENTitle: Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson’s diseaseJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-020-00134-xBest OA location URL: https://www.nature.com/articles/s41531-020-00134-x.pdfCitation Count: 44
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OPENTitle: Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathiesJournal Name: Human Molecular GeneticsPublisher: Oxford University Press (OUP)Vol: 28Issue #: 4Start Page: 548End Page: 560Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/hmg/ddy365Best OA location URL: https://academic.oup.com/hmg/article-pdf/28/4/548/27636558/ddy365.pdfCitation Count: 65
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OPENTitle: Severe cholinergic terminal loss in newly diagnosed dementia with Lewy bodiesJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 146Issue #: 9Start Page: 3690End Page: 3704Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/awad192Best OA location URL: https://academic.oup.com/brain/article-pdf/146/9/3690/51330532/awad192.pdfCitation Count: 27
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OPENTitle: Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in VivoJournal Name: ACS Chemical BiologyPublisher: American Chemical Society (ACS)Vol: 11Issue #: 8Start Page: 2105End Page: 2111Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/acschembio.6b00217Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4992440Citation Count: 68
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OPENTitle: Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle TraffickingJournal Name: Frontiers in NeurosciencePublisher: Frontiers Media SAVol: 15Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnins.2021.639414Best OA location URL: https://doi.org/10.3389/fnins.2021.639414Citation Count: 16
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OPENTitle: Parkinson’s-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and composition in striatum with cell-type and subunit specificityJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 121Issue #: 28Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1073/pnas.2317833121Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/11252801Citation Count: 2
- Exploring [11C]CPPC as a CSF1R-targeted PET imaging marker for early Parkinson’s disease severity2025OPENTitle: Exploring [11C]CPPC as a CSF1R-targeted PET imaging marker for early Parkinson’s disease severityJournal Name: Journal of Clinical InvestigationPublisher: American Society for Clinical InvestigationVol: 135Issue #: 12Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1172/jci186591Best OA location URL: http://www.jci.org/articles/view/186591/files/pdfCitation Count: 0
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OPENTitle: Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharideJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 108Issue #:Start Page: 115End Page: 127Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2017.08.009Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5734673Citation Count: 63
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RESTRICTEDTitle: Global Perspectives on Returning Genetic Research Results in Parkinson DiseaseJournal Name: Neurology GeneticsPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 10Issue #: 6Start Page:End Page:Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1212/nxg.0000000000200213Best OA location URL: https://www.neurology.org/doi/pdfdirect/10.1212/NXG.0000000000200213Citation Count: 0
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OPENTitle: The diagnostic accuracy of the hummingbird and morning glory sign in patients with neurodegenerative parkinsonismJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 54Issue #:Start Page: 90End Page: 94Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.04.005Best OA location URL: http://www.prd-journal.com/article/S1353802018301500/pdfCitation Count: 62
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OPENTitle: Olfactory dysfunction in incidental Lewy body disease and Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 20Issue #: 11Start Page: 1260End Page: 1262Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2014.08.006Citation Count: 73
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OPENTitle: Effect of augmenting cholinergic function on gait and balanceJournal Name: BMC NeurologyPublisher: Springer Science and Business Media LLCVol: 15Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12883-015-0523-xBest OA location URL: https://bmcneurol.biomedcentral.com/track/pdf/10.1186/s12883-015-0523-xCitation Count: 25
- Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles2024OPENTitle: Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profilesJournal Name: eLifePublisher: eLife Sciences Publications, LtdVol: 13Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.7554/elife.92775.3Best OA location URL: https://cdn.elifesciences.org/articles/92775/elife-92775-v1.pdfCitation Count: 2
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OPENTitle: Methamphetamine‐induced mitochondrial oxidant stress mediated by monoamine oxidase metabolism of dopamineJournal Name: The FASEB JournalPublisher: WileyVol: 31Issue #: S1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1096/fasebj.31.1_supplement.987.3Best OA location URL: https://doi.org/10.1096/fasebj.31.1_supplement.987.3Citation Count: 3
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RESTRICTEDTitle: Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l-Dopa-induced dyskinesia in experimental Parkinson's diseaseJournal Name: Experimental NeurologyPublisher: Elsevier BVVol: 304Issue #:Start Page: 143End Page: 153Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.expneurol.2018.03.008Citation Count: 29
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RESTRICTEDTitle: Advantages of timing the duration of a freezing of gait-provoking test in individuals with Parkinson’s diseaseJournal Name: Journal of NeurologyPublisher: Springer Science and Business Media LLCVol: 267Issue #: 9Start Page: 2582End Page: 2588Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s00415-020-09856-7Citation Count: 9
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OPENTitle: Heritability estimates of cortical anatomy: The influence and reliability of different estimation strategiesJournal Name: NeuroImagePublisher: Elsevier BVVol: 178Issue #:Start Page: 78End Page: 91Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuroimage.2018.05.014Best OA location URL: https://eprints.lancs.ac.uk/id/eprint/125120/1/1_s2.0_S1053811918304129_main.pdfCitation Count: 21
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OPENTitle: Thermodynamic characterization of amyloid polymorphism by microfluidic transient incomplete separationJournal Name: Chemical SciencePublisher: Royal Society of Chemistry (RSC)Vol: 15Issue #: 7Start Page: 2528End Page: 2544Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1039/d3sc05371gBest OA location URL: https://pubs.rsc.org/en/content/articlepdf/2024/sc/d3sc05371gCitation Count: 13
- Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinson’s disease2016RESTRICTEDTitle: Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinson’s diseaseJournal Name: Science Translational MedicinePublisher: American Association for the Advancement of Science (AAAS)Vol: 8Issue #: 360Start Page:End Page:Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1126/scitranslmed.aad8858Citation Count: 68
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OPENTitle: Predicting Progression in Parkinson’s Disease Using Baseline and 1-Year Change MeasuresJournal Name: Journal of Parkinson's DiseasePublisher: SAGE PublicationsVol: 9Issue #: 4Start Page: 665End Page: 679Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.3233/jpd-181518Best OA location URL: https://content.iospress.com:443/download/journal-of-parkinsons-disease/jpd181518?id=journal-of-parkinsons-disease%2Fjpd181518Citation Count: 20
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OPENTitle: Recruitment for Remote Decentralized Studies in Parkinson’s DiseaseJournal Name: Journal of Parkinson's DiseasePublisher: SAGE PublicationsVol: 12Issue #: 1Start Page: 371End Page: 380Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.3233/jpd-212935Best OA location URL: https://content.iospress.com:443/download/journal-of-parkinsons-disease/jpd212935?id=journal-of-parkinsons-disease%2Fjpd212935Citation Count: 15
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RESTRICTEDTitle: Vocal tics in Tourette's syndromeJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 15Issue #: 3Start Page: e1End Page: e1Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(16)00021-1Citation Count: 4