The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Examining GCase Activity in People with REM Sleep Behavior Disorder
Study Rationale:
Approximately 80 percent of people with REM sleep behavior disorder (RBD) will develop a neurological disorder such as Parkinson's disease (PD). GBA mutations are the most frequent... -
Research Grant, 2019Discovery and Development of Parkin Activators as Therapies for Parkinson’s Disease
Study Rationale:
Impaired mitochondria are a shared feature of Parkinson's disease (PD). Thus restoration of mitochondrial function offers a therapeutic avenue to slow the progression of PD. Parkin... -
Research Grant, 2016Investigation of the Role of PINK1-dependent Phosphorylation of Rab GTPases in Parkinson’s Disease
Study Rationale:
Mutations in the PINK1 gene lead to Parkinson’s disease. PINK1 belongs to a special class of enzymes known as protein kinases. We recently found that PINK1 targets a family of enzymes... -
Research Grant, 2019Supplement: Investigation of PINK1-dependent Phosphorylation of Rab GTPases
Promising Outcomes of Original Grant:
We were trying to understand how the PINK1 gene targets a set of proteins known as Rab GTPases through protein modification known as phosphorylation. The... -
Improved Biomarkers and Clinical Outcome Measures, 2019Applying Artificial Intelligence for Early Identification of Parkinson’s Disease
Study Rationale:
The nervous system regulates heart rate in response to situations such as stress and emergencies. Dysfunction of part of the nervous system controlling the heart can cause changes in... -
Priority Target Award, 2016Advancing PINK1 Knockout Models of Parkinson’s
Study Rationale:
Loss-of-function mutations in PINK1 are causally linked to early-onset Parkinson’s disease (PD). MJFF funded the generation and initial characterization of PINK1 knockout (KO) models...
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Our funding programs support basic, translational and clinical research from academia and industry.