The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2025Enhancing Recruitment of Individuals Traditionally Underrepresented in Parkinson’s Disease Research into the SPARX3 Clinical Trial
Study Rationale: SPARX3 is a Phase 3 clinical trial designed to assess whether high intensity aerobic exercise can delay progression of Parkinson’s disease (PD) better than does moderate intensity...
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Neuronal Synuclein Disease Endotypes 2024, 2025Assessing the Aggregation of Alpha-synuclein Across Aging, Alzheimer’s Disease and Dementia with Lewy Bodies
Study Rationale: Forms of alpha-synuclein, the protein that aggregates in Parkinson’s disease (PD), can be detected in cerebrospinal fluid (CSF) by seed amplification assays (SAA). These highly...
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Research Grant, 2025Evaluation of Novel PET Probes for Alpha-synuclein Imaging
Study Rationale: Aggregation of the protein alpha-synuclein into fibrils in Lewy bodies and Lewy neurites is the key pathological feature of Parkinson's disease (PD) and related synucleinopathies...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biomarkers, 2025Development of an Assay for Rapid Detection of Activated LRRK2
Study Rationale: Mutations associated with Parkinson’s disease (PD) elevate the activity of a protein called Leucine-rich repeat kinase 2 (LRRK2). Kinases add phosphate groups to other proteins and to...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2025Accelerating Biological Understanding and Therapeutic Translation for PD-Biology
Study Rationale: Mutations in the PINK1 and Parkin genes cause early-onset Parkinson’s disease (PD). In rats with similar mutations in PINK1 and Parkin, we observed pronounced degeneration of nerve...
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Freezing of Gait Program, 2025Treating Freezing of Gait in Parkinson’s Disease Using an ADHD Drug that Reduces Neural Cross-talk: A Multi-center Multi-modal Approach
Study Rationale: Freezing of gait affects four out of five people with Parkinson’s disease (PD), yet this debilitating symptom is not fully treated by any PD medication available. Research has shown...
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Our funding programs support basic, translational and clinical research from academia and industry.