The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkinson’s Disease Therapeutics Pipeline Program, 2025PINK1 Activators for Treating Parkinson's Disease
Study Rationale: Parkinson’s disease (PD) is caused by the loss of neurons in the brain due to their inability to remove damaged and dysfunctional mitochondria. PINK1 kinase located on mitochondria is...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Development of Anti-TLR2 Antibody Encapsulated with Polymer Nanoparticles Using a DNA Bar-coding Technology for Enhanced Brain Delivery
Study Rationale: Parkinson’s disease (PD) worsens over time, partly due to the spread of a harmful protein called α-synuclein between brain cells. This protein also triggers inflammation, which...
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Seed Amplification Assay Innovation Program, 2025Blood-based Same-day Nano-QuIC for Rapid Detection of Misfolded Alpha-synuclein in Parkinson's Disease
Study Rationale: Parkinson’s disease is caused by the accumulation of misfolded alpha-synuclein, a protein that spreads in the brain and nervous system. Current cerebrospinal fluid (CSF) tests require...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Development of a Sequence Specific LRRK2-targeted Parkinson's Disease Splice Switching Oligonucleotide Drugs
Study Rationale: Some forms of Parkinson’s disease are caused by inherited mutations in the LRRK2 gene, and these mutations change the LRRK2 protein in such a way that it becomes too active. The LRRK2...
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Research Grant, 2025Measurement of 1-deoxysphingolipids in Parkinson’s Disease Plasma
Study Rationale: The sphingolipid metabolic pathway is large and complex, comprising hundreds of lipids critical to normal cellular and brain function. Variants in multiple genes regulating...
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T2T Validation - NOD2, 2025Characterizing NOD2 Genetic Landscape Driving Risk of Parkinson’s Disease
Study Rationale: The NOD2 protein plays a key role in how the immune system detects bacteria and protects the gut. Recent research suggests that genetic variation in the NOD2 gene may be linked to...
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Our funding programs support basic, translational and clinical research from academia and industry.