The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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T2T Validation - NOD2, 2025Development and Validation of Synthetic NOD2 Modulators for Parkinson’s Disease
Study Rationale: The expression and activity of NOD2, an important immune pattern recognition receptor, is associated with neuroinflammation and Parkinson’s disease (PD) and promising therapeutic...
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T2T Validation - NOD2, 2025Modulating Levels of NOD2 Ligands in the Gut Microbiota to Dampen Neuro-inflammation in Parkinson’s Disease
Study Rationale: Recent research suggests that a protein in our cells involved in bacterial detection, called NOD2, may play a role in the development of Parkinson’s disease (PD) by triggering harmful...
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Research Grant, 2025Dynamic Microsimulation of Parkinson’s Disease: Evaluating Lifecourse Impacts of Disease Modifying Therapies (VALUE-PD)
Study Rationale: As new treatments for Parkinson's disease (PD) are developed, it is important to understand how they might affect the health and finances of people with PD, their families, and...
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T2T Validation - NOD2, 2025Investigating the Potential Role of NOD2 Activation in Reducing a-synuclein Aggregation and Toxicity in Human Cellular and Pre-clinical Models of Parkinson’s Disease
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Development of OT-1xx2, a Novel Small Molecule TrkB Activator, for the Treatment of Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) poses a huge disease burden to patients and their families. Current approved therapies are largely focused on symptom relief and have little impact on the...
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Neuronal Synuclein Disease Endotypes 2024, 2025BIOLOGY IS THE DISEASE: Identifying Biological Endophenotypes Based on Alpha-synuclein and AD Pathology Profiles and Evaluate NSD-ISS Stage 3-6
Study Rationale: In the era where we aim to define diseases by biology and modifying treatment options become available for neurodegenerative diseases, the clinicopathological heterogeneity in alpha...
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Our funding programs support basic, translational and clinical research from academia and industry.