The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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LEAPS, 2007Therapeutic Development of siRNA Targeting Alpha-Synuclein
Objective/Rationale:
Clinical, genetic and experimental evidence supports an association between alpha-synuclein expression and Parkinson’s disease. This toxicity is likely to be attenuated by... -
Critical Challenges in PD: Translating Genetic Findings Into, 2007Dopamine Toxicity Hypothesis: Interaction with Alpha-Synuclein in the Intact Brain
Objective/Rationale:
Identification of mutations in the alpha-synuclein gene in a familial form of Parkinson’s disease, then the demonstration of alpha-synuclein containing pathological aggregations... -
Critical Challenges in PD: Translating Genetic Findings Into, 2007Elucidating the Role of Phosphorylation in modulating alpha-synuclein aggregation and toxicity in Parkinson's disease and related disorders
Objective/Rationale:
Chemical changes in the protein alpha-synuclein, such as the binding of phosphate groups (phosphorylation), are characteristic of Parkinson's disease and related alpha... -
Critical Challenges in PD: Translating Genetic Findings Into, 2007Impact of Post-Translational Modifications on the Neurotoxicity of Alpha-Synuclein in Parkinson's Disease
Objective/Rationale:
The loss of neurons in the brains of Parkinson’s disease patients may be caused by harmful clusters or ‘aggregates’ of alpha-synuclein, an abundant protein in the central nervous... -
Critical Challenges in PD: Translating Genetic Findings Into, 2007Genetic Dissection of LRRK2 Domains Critical For Pathogenesis via BAC Transgenic Approach
Objective/Rationale:
Mutations in the LRRK2 gene are responsible for certain types of familial Parkinson’s disease. The protein product of the LRRK2 gene has a complex structure and to date, research... -
Critical Challenges in PD: Translating Genetic Findings Into, 2007Delivery of Kinase-Modified LRRK2 to Dopaminergic Neurons Using High-Capacity Viral Vectors
Objective/Rationale:
Mutations in the LRRK2 gene unambiguously associate with the development of late-onset Parkinson’s disease that mimics clinical and neurochemical features typical of the disease...
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Our funding programs support basic, translational and clinical research from academia and industry.