The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Dopamine-Non-Responsive Symptoms of Parkinson's Disease, 2006Development of a Model of Postural Disturbance by Lesioning Non-cholinergic Neurons
Mounting evidence suggests that a small structure at the bottom of the brain called pedunculopontine nucleus is involved in the development of gait failure and postural instability in PD. We propose...
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Dopamine-Non-Responsive Symptoms of Parkinson's Disease, 2006Evaluation of gastrointestinal motility in parkinsonian rodents
Gastrointestinal (GI) symptoms, such as nausea, bloating, and constipation occur in nearly every patient afflicted with Parkinson's Disease (PD) at some point in their illness. These symptoms on their...
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Community Fast Track, 2006The Role of Serotonin Neurons in the Induction of Dyskinesia in Grafted and L-DOPA-primed Animals
Levodopa, which is the most commonly used medication for patients with Parkinson's disease, is a beneficial therapy, but as the disease progresses it can be the cause of debilitating involuntary...
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MJFF Research Grant, 2006A Phase II Clinical Trial of Neurturin (NTN) Gene Therapy for PD
Objective/Rationale:
Neurotrophic factors including neurturin (NTN) have been shown to effectively augment the function and prevent the death of dopaminergic nigrostriatal neurons in animal models of... -
MJFF Research Grant, 2006The Unified Dyskinesia Rating Scale (UDysRS): Clinimetric Testing Program
In Parkinson’s disease, one of the most troubling clinical issues for prevention and management is drug-induced dyskinesia. Dyskinesias are abnormal and involuntary movements that relate in part to...
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MJFF Research Grant, 2006PDGene
Parkinson’s disease is a genetically complex and heterogeneous disorder. To date, mutations in five genes have been identified to cause early-onset parkinsonism, which typically follows Mendelian...
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Our funding programs support basic, translational and clinical research from academia and industry.