The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2011Ghrelin Agonist as a Novel Therapeutic Approach to Alleviate Gut Dysmotility and Levodopa-inhibited Gastric Emptying in PD Models
Objective/Rationale:
Patients with Parkinson’s disease (PD) have altered progression of ingested aliments/liquid from their stomach to the intestine, as well as suffer from constipation, and there is...
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MJFF Research Grant, 2011Structural, Post-translational Modification and Small Chemical Approaches to Understand LRRK2 Function in PD
Promising Outcomes of Original Grant:
Our original goal was to (1) establish electron microscopy (EM)-based dimeric structural assays for the LRRK2 protein and (2) develop high-throughput kinase assays... -
LRRK2, 2011Analytic Models in Biomarker Development
Objective/Rationale:
Non-invasive tests or biomarkers may aid clinical trials if they help to identify a subgroup of individuals at high risk of Parkinson's disease (PD), or if they are able to... -
Therapeutics Development Initiative, 2011Testing of Ambroxol in the Thy1-Alpha-Synuclein Pre-clinical Model of Parkinson's disease
Objective/Rationale:
Biochemical evidence suggests that blocking the maturation of a natural enzyme, glucocerebrosidase (GCase), can cause the build-up of alpha-synuclein deposits in neurons. Such... -
LRRK2 Cohort Working Group, 2011Gait and Motor Symptoms in Healthy Asymptomatic Relatives of Patients with PD Who Are Carriers of Mutations in the LRRK2 Gene
Objective/Rationale:
Gait disturbances play a major role in the motor manifestation of Parkinson's disease (PD). We aim to explore the possibility that subtle gait alterations are also present in the... -
LRRK2 Challenge, 2011Regulation of LRRK2 Activity by Nitric Oxide-Mediated Protein S-Nitrosylation
Objective/Rationale:
Mutations in the LRRK2 gene are a common cause of familial Parkinson’s disease (PD). Familial mutations can influence the GTPase or kinase activity of LRRK2 which may be...
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Our funding programs support basic, translational and clinical research from academia and industry.