The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Expanding Biological Understanding of PD, 2021Assessing Inhibition of NLRP3 to Reduce Brain Inflammation in Parkinson’s Disease
Study Rationale:
Recent studies indicate that brain inflammation caused by activation of a protein complex called the NLRP3 inflammasome worsens Parkinson’s disease (PD). Although multiple drugs that... -
Therapeutic Pipeline Program, 2021Using Ketamine to Treat Depression in Parkinson’s Disease
Study Rationale:
Depression affects around half of people with Parkinson’s disease (PD). However, existing antidepressants are not effective in treating these symptoms in PD and new treatments are... -
Outcome Measures, 2021Assessing Parkinson’s at Home: Contactless Monitoring of Sleep, Motor Symptom Progression and Medication Response
Study Rationale:
The ability to accurately monitor Parkinson’s disease (PD) progression and medication response at home can significantly benefit disease management and drug development. In the past... -
Therapeutic Pipeline Program, 2021Harnessing the ADAR Protein to Repair the LRRK2 Mutation Causing Parkinson's Disease
Study Rationale:
The majority of cases of inherited Parkinson’s disease (PD) are caused by a single-letter change in the gene that encodes the LRRK2 protein. The mutation, which changes a G to an... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Using Risk Scores to Link Molecular Mechanisms to Clinical Outcomes in Parkinson's Disease
Study Rationale:
The symptoms and course of Parkinson’s disease (PD) show remarkable variation from one person to another, indicating differences in the underlying disease process that may also be... -
Target Advancement Program, 2021Developing a Protein Quality Control Mechanism as a Novel Therapy for Parkinson’s Disease
Study Rationale:
Parkinson’s disease is a disorder of protein misfolding and aggregation. It is characterized by the presence of Lewy bodies and Lewy neurites: aberrant intracellular structures...
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Our funding programs support basic, translational and clinical research from academia and industry.