The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2007Unraveling the genetic basis for alpha-synuclein oligomerization in living cells using bimolecular fluorescence complementation
Oligomerization of alpha-synuclein is hypothesized to be the pathogenic mechanism of protein aggregate formation and cell death in neurons of PD patients. Dr. Outeiro proposes to develop an assay to...
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Community Fast Track, 2007Gene Therapy for Parkinson's Disease: Does Re-expression of HCN2 in GPe Improve Motor Deficits in Rodent PD Model?
Promising Outcomes of Original Grant:
We hypothesized that dopamine depletion in Parkinson’s disease results in downregulation of a specific ion channel, termed HCN2, in neurons of the external... -
Community Fast Track, 2007Elucidating the Role of Nurr1 in Protection of Adult Dopamine Neurons of the Substantia Nigra
Promising Outcomes of Original Grant:
Nurr1 is a transcription factor that is known to be important for the development of dopamine neurons. However, it continues to be expressed also in the adult... -
Community Fast Track, 2007The Protein Engrailed as a Potential Therapeutic Target in Parkinson's Disease
Promising Outcomes of Original Grant:
In our original grant, we have confirmed that a protein called Engrailed (which plays an important role both in the developping and in the adult dopaminergic... -
Community Fast Track, 2007CDNF - A Novel Conserved Neurotrophic Factor that Protects Midbrain Dopaminergic Neurons in vivo
Promising Outcomes of Original Grant:
Future treatment of Parkinson’s disease aim at therapies which would stop the progress of the disease and restore the function of injured dopamine nerves in the... -
Target Validation, 2007Targeting Urate: A Molecular Correlate of Both Risk and Progression in PD
Objective/Rationale:
Urate (a natural antioxidant, caffeine analog and DNA metabolite) is the first molecule linked to both the risk of typical Parkinson’s disease and its rate of progression. Higher...
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Our funding programs support basic, translational and clinical research from academia and industry.