The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2023Developing Wiring Diagrams of the Brain-Body Connection
Study Rationale: Individuals with Parkinson’s disease (PD) can show a variety of symptoms, including: resting tremors, alterations in directed hand movements, and treatment-induced dyskinesias; loss...
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Therapeutic Pipeline Program, 2023Evaluation of the Inflammation-blocking Drug Tolebrutinib as a Novel Disease-modifying Therapeutic for Parkinson's Disease
Study Rationale: Our project will test the effectiveness of a new treatment for Parkinson’s disease (PD). Developed by Sanofi, the drug — called Tolebrutinib — blocks inflammation in the brain. Based...
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Research Grant, 2023Exploiting a Novel Mechanism for Gene Regulation to Develop Innovative, Targeted Therapies for Parkinson’s Disease
Study Rationale: Neurodegenerative disorders such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) are associated with a variety of disease-causing mutations and genetic variants. In addition...
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Translational Pipeline Program, 2023Development of a Small Interfering RNA that Reduces Production of Alpha-synuclein in Parkinson's Disease
Study Rationale: Parkinson’s disease (PD) is associated with a buildup of alpha-synuclein aggregates in the brain. Modulation of alpha-synuclein accumulation has been shown in multiple preclinical...
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Accelerating the Translation of Parkinson's Disease Therapies, 2022Esya PD360: A Multi-parametric Platform for Establishing a Novel Lysosome-based Biomarker and Identifying Therapeutic Interventions for Parkinson’s Disease
Study Rationale: Lysosomes are sub-cellular compartments responsible for clearing proteins that are prone to aggregation, a process called autophagy. Dysfunctional lysosomes with increased acidity and...
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Research Grant, 2022Perspective and Consensus on Prevention Planning for Parkinson’s Disease
Study Rationale: In October 2022, a conference on “Planning for Prevention of Parkinson's: A trial design forum” gathered a broad range of stakeholders interested in preventing Parkinson’s disease (PD...
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Our funding programs support basic, translational and clinical research from academia and industry.