To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Rab 10 pT73 Phosphospecific Antibody (IP/WB)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine73 of the Rab 10 protein. Recommended for immunoblot and immunoprecipitation. A separate antibody (ab241060) is available for immunostaining.
Rab 29 pT71 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine71 of the human Rab 29 protein. Suitable for immunoblot experiments.
Total Rab 10 Antibody
Antibody
Rabbit monoclonal antibody directed against the total Rab 10 protein. Suitable for immunoblot, immunoprecipitation, immunofluorescent staining, and flow cytometry experiments. This antibody epitope was mapped to C-terminus amino acids 185-193.
LRRK2 G2019S KI Mouse
Mouse Model
Mice expressing the human G2019S point mutation introduced into exon 41 of the mouse LRRK2 gene.
Rab 12 pS106 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine106 of the human Rab 12 protein. Suitable for immunoblot experiments.
Parkin W402A KI Mouse
Mouse Model
CRISPR/Cas9 generated mice carrying the Park2, Parkinson disease (autosomal recessive, juvenile) 2, parkin, W402A point mutation in exon 11.
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:029317
Rat Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length rat alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note: Validation of the rat alpha-synuclein monomers for making pre-formed fibrils identified a lack of pathology in vitro in mouse primary hippocampal neurons and in vivo in rat. Email tools@michaeljfox.org with questions or for more information.
Mouse Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length mouse alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note, we recommend this protein for in vitro studies but not for in vivo experiments (the protein as validated for pS129 alpha-synuclein pathology in vitro but in vivo validation failed as robust pS129 alpha-synuclein pathology was not observed).
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
*Discontinued for fibrils lack of seeding activity.
Total Rab 35 Antibody
Antibody
Monoclonal antibody directed against total Rab35 protein. Suitable for immunoblot experiments.
Total Rab 10 Antibody
Antibody
Mouse monoclonal antibody directed against the human total Rab 10 protein. This antibody has been validated for immunoblotting experiments. This antibody epitope was mapped to amino acids 127-133.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic