5101 - 5150 of 5898 Results
Title
Year
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OPENTitle: Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microgliaJournal Name: Journal of NeuroinflammationPublisher: Springer Science and Business Media LLCVol: 11Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12974-014-0164-9Best OA location URL: https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-014-0164-9Citation Count: 26
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OPENTitle: DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative StressJournal Name: PLoS ONEPublisher: Public Library of Science (PLoS)Vol: 9Issue #: 9Start Page: e106601End Page: e106601Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0106601Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106601&type=printableCitation Count: 45
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OPENTitle: Hemispheric asymmetry of electroencephalography-based functional brain networksJournal Name: NeuroReportPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 25Issue #: 16Start Page: 1266End Page: 1271Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1097/wnr.0000000000000256Best OA location URL: https://europepmc.org/articles/pmc4809244?pdf=renderCitation Count: 10
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OPENTitle: Multiple system atrophy is not caused by C9orf72 hexanucleotide repeat expansionsJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 36Issue #: 2Start Page: 1223.e1End Page: 1223.e2Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2014.08.033Best OA location URL: https://europepmc.org/articles/pmc4315721?pdf=renderCitation Count: 29
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OPENTitle: APOE,MAPT, andSNCAGenes and Cognitive Performance in Parkinson DiseaseJournal Name: JAMA NeurologyPublisher: American Medical Association (AMA)Vol: 71Issue #: 11Start Page: 1405End Page: 1405Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1001/jamaneurol.2014.1455Best OA location URL: https://europepmc.org/articles/pmc4227942?pdf=renderCitation Count: 186
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OPENTitle: Olfactory identification in LRRK 2 G2019S mutation carriers: a relevant marker?Journal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 1Issue #: 9Start Page: 670End Page: 678Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.95Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.95Citation Count: 38
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OPENTitle: Genetic variability in the regulation of gene expression in ten regions of the human brainJournal Name: Nature NeurosciencePublisher: Springer Science and Business Media LLCVol: 17Issue #: 10Start Page: 1418End Page: 1428Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/nn.3801Best OA location URL: https://europepmc.org/articles/pmc4208299?pdf=renderCitation Count: 649
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OPENTitle: Biochemical Assessment of Precuneus and Posterior Cingulate Gyrus in the Context of Brain Aging and Alzheimer’s DiseaseJournal Name: PLoS ONEPublisher: Public Library of Science (PLoS)Vol: 9Issue #: 8Start Page: e105784End Page: e105784Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0105784Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0105784&type=printableCitation Count: 15
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OPENTitle: BDNF polymorphism associates with decline in set shifting in Parkinson's diseaseJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 36Issue #: 3Start Page: 1605.e1End Page: 1605.e6Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2014.08.023Citation Count: 46
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OPENTitle: Cadherin‐8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuitsJournal Name: Journal of Comparative NeurologyPublisher: WileyVol: 523Issue #: 1Start Page: 75End Page: 92Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/cne.23666Best OA location URL: https://europepmc.org/articles/pmc4232472?pdf=renderCitation Count: 36
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OPENTitle: Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFADmice, an animal model of Alzheimer's diseaseJournal Name: Journal of NeurochemistryPublisher: WileyVol: 132Issue #: 2Start Page: 254End Page: 262Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/jnc.12935Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.12935Citation Count: 40
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OPENTitle: Vagus Nerve Stimulation During Rehabilitative Training Improves Functional Recovery After Intracerebral HemorrhageJournal Name: StrokePublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 45Issue #: 10Start Page: 3097End Page: 3100Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1161/strokeaha.114.006654Best OA location URL: https://europepmc.org/articles/pmc4175144?pdf=renderCitation Count: 124
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OPENTitle: Course of psychiatric symptoms and global cognition in early Parkinson diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 83Issue #: 12Start Page: 1096End Page: 1103Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0000000000000801Best OA location URL: https://europepmc.org/articles/pmc4166362?pdf=renderCitation Count: 116
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OPENTitle: Interest in Genetic Testing in Ashkenazi Jewish Parkinson's Disease Patients and Their Unaffected RelativesJournal Name: Journal of Genetic CounselingPublisher: WileyVol: 24Issue #: 2Start Page: 238End Page: 246Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s10897-014-9756-xBest OA location URL: https://europepmc.org/articles/pmc4331260?pdf=renderCitation Count: 28
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OPENTitle: Olfactory dysfunction in incidental Lewy body disease and Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 20Issue #: 11Start Page: 1260End Page: 1262Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2014.08.006Best OA location URL: https://europepmc.org/articles/pmc4835172?pdf=renderCitation Count: 73
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OPENTitle: Nicotinic Acetylcholine Receptor Density in Cognitively Intact Subjects at an Early Stage of Parkinson’s DiseaseJournal Name: Frontiers in Aging NeurosciencePublisher: Frontiers Media SAVol: 6Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3389/fnagi.2014.00213Best OA location URL: https://europepmc.org/articles/pmc4132266?pdf=renderCitation Count: 24
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OPENTitle: Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorderJournal Name: Frontiers in Human NeurosciencePublisher: Frontiers Media SAVol: 8Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnhum.2014.00627Best OA location URL: https://www.frontiersin.org/articles/10.3389/fnhum.2014.00627/pdfCitation Count: 55
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OPENTitle: Relationships among cognitive impairment, sleep, and fatigue in Parkinson's disease using the MDS-UPDRSJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 20Issue #: 11Start Page: 1135End Page: 1139Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2014.08.001Best OA location URL: https://europepmc.org/articles/pmc4252982?pdf=renderCitation Count: 48
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OPENTitle: Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α‐synucleinJournal Name: Pharmacology Research & PerspectivesPublisher: WileyVol: 2Issue #: 5Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1002/prp2.65Best OA location URL: https://doi.org/10.1002/prp2.65Citation Count: 41
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OPENTitle: Independent Spanish Validation of the Unified Dyskinesia Rating ScaleJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 1Issue #: 3Start Page: 213End Page: 218Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mdc3.12065Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12065Citation Count: 8
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OPENTitle: Michael J. Fox Foundation LRRK2 Consortium: geographical differences in returning genetic research data to study participantsJournal Name: Genetics in MedicinePublisher: Elsevier BVVol: 16Issue #: 8Start Page: 644End Page: 645Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/gim.2014.55Best OA location URL: https://europepmc.org/articles/pmc4682659?pdf=renderCitation Count: 7
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OPENTitle: Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body ClearingJournal Name: CellPublisher: Elsevier BVVol: 158Issue #: 4Start Page: 945End Page: 958Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.cell.2014.07.017Best OA location URL: http://www.cell.com/article/S0092867414009313/pdfCitation Count: 895
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OPENTitle: Genetic impact on cognition and brain function in newly diagnosed Parkinson’s disease: ICICLE-PD studyJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 137Issue #: 10Start Page: 2743End Page: 2758Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1093/brain/awu201Best OA location URL: https://academic.oup.com/brain/article-pdf/137/10/2743/11140806/awu201.pdfCitation Count: 142
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OPENTitle: Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass SpectrometryJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-saDOI - Digital Object Identifier: 10.1038/srep05797Best OA location URL: https://www.nature.com/articles/srep05797.pdfCitation Count: 152
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OPENTitle: Abnormal MoCA and normal range MMSE scores in Parkinson disease without dementia: Cognitive and neurochemical correlatesJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 20Issue #: 10Start Page: 1076End Page: 1080Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2014.07.008Best OA location URL: https://europepmc.org/articles/pmc4180768?pdf=renderCitation Count: 70
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OPENTitle: Naltrexone for impulse control disorders in Parkinson diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 83Issue #: 9Start Page: 826End Page: 833Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0000000000000729Best OA location URL: https://europepmc.org/articles/pmc4155050?pdf=renderCitation Count: 79
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OPENTitle: A GCase Chaperone Improves Motor Function in a Mouse Model of SynucleinopathyJournal Name: NeurotherapeuticsPublisher: Elsevier BVVol: 11Issue #: 4Start Page: 840End Page: 856Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s13311-014-0294-xBest OA location URL: https://europepmc.org/articles/pmc4391384?pdf=renderCitation Count: 97
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OPENTitle: A brain network response to sham surgeryJournal Name: Journal of Clinical InvestigationPublisher: American Society for Clinical InvestigationVol: 124Issue #: 8Start Page: 3285End Page: 3288Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1172/jci77193Best OA location URL: http://www.jci.org/articles/view/77193/files/pdfCitation Count: 5
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OPENTitle: Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 ratsJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 36Issue #: 1Start Page: 505End Page: 518Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2014.07.011Best OA location URL: https://europepmc.org/articles/pmc5289148?pdf=renderCitation Count: 46
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OPENTitle: ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In VivoJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 22Issue #: 10Start Page: 1753End Page: 1767Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-saDOI - Digital Object Identifier: 10.1038/mt.2014.129Best OA location URL: http://www.cell.com/article/S1525001616307808/pdfCitation Count: 80
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OPENTitle: Hypersynchrony despite pathologically reduced beta oscillations in patients with Parkinson's disease: a pharmaco-magnetoencephalography studyJournal Name: Journal of NeurophysiologyPublisher: American Physiological SocietyVol: 112Issue #: 7Start Page: 1739End Page: 1747Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1152/jn.00383.2014Best OA location URL: https://europepmc.org/articles/pmc4157173Citation Count: 78
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OPENTitle: Subthalamic nucleus—sensorimotor cortex functional connectivity in de novo and moderate Parkinson's diseaseJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 36Issue #: 1Start Page: 462End Page: 469Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2014.07.004Best OA location URL: https://europepmc.org/articles/pmc4268125?pdf=renderCitation Count: 47
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OPENTitle: A Neurodegenerative Vascular Burden Index and the Impact on CognitionJournal Name: Frontiers in Aging NeurosciencePublisher: Frontiers Media SAVol: 6Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnagi.2014.00161Best OA location URL: https://www.frontiersin.org/articles/10.3389/fnagi.2014.00161/pdfCitation Count: 14
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OPENTitle: Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic miceJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 111Issue #: 29Start Page: 10732End Page: 10737Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1321785111Best OA location URL: https://www.pnas.org/content/pnas/111/29/10732.full.pdfCitation Count: 289
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OPENTitle: Noninvasive optical inhibition with a red-shifted microbial rhodopsinJournal Name: Nature NeurosciencePublisher: Springer Science and Business Media LLCVol: 17Issue #: 8Start Page: 1123End Page: 1129Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/nn.3752Best OA location URL: https://dspace.mit.edu/bitstream/1721.1/98648/1/920678211-MIT.pdfCitation Count: 525
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OPENTitle: Adipose and leptomeningeal arteriole endothelial dysfunction induced by β-amyloid peptide: A practical human model to study Alzheimer's disease vasculopathyJournal Name: Journal of Neuroscience MethodsPublisher: Elsevier BVVol: 235Issue #:Start Page: 123End Page: 129Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.jneumeth.2014.06.014Best OA location URL: https://europepmc.org/articles/pmc4175686?pdf=renderCitation Count: 15
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OPENTitle: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriersJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 137Issue #: 9Start Page: 2480End Page: 2492Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1093/brain/awu179Best OA location URL: https://academic.oup.com/brain/article-pdf/137/9/2480/13798270/awu179.pdfCitation Count: 176
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OPENTitle: Factors Influencing the Measurement of Lysosomal Enzymes Activity in Human Cerebrospinal FluidJournal Name: PLoS ONEPublisher: Public Library of Science (PLoS)Vol: 9Issue #: 7Start Page: e101453End Page: e101453Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0101453Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0101453&type=printableCitation Count: 25
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OPENTitle: Plaques and tangles as well as Lewy-type alpha synucleinopathy are associated with formed visual hallucinationsJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 20Issue #: 9Start Page: 1009End Page: 1014Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2014.06.018Best OA location URL: https://escholarship.org/content/qt3sr2x695/qt3sr2x695.pdf?t=rus9dgCitation Count: 46
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OPENTitle: Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodiesJournal Name: Human Molecular GeneticsPublisher: Oxford University Press (OUP)Vol: 23Issue #: 23Start Page: 6139End Page: 6146Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/hmg/ddu334Best OA location URL: https://digital.library.adelaide.edu.au/dspace/bitstream/2440/121212/2/hdl_121212.pdfCitation Count: 206
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OPENTitle: Decreased Cough Sensitivity and Aspiration in Parkinson DiseaseJournal Name: ChestPublisher: Elsevier BVVol: 146Issue #: 5Start Page: 1294End Page: 1299Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1378/chest.14-0066Best OA location URL: https://europepmc.org/articles/pmc4219343?pdf=renderCitation Count: 116
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OPENTitle: Functional Brain Activity Relates to 0–3 and 3–8 Hz Force Oscillations in Essential TremorJournal Name: Cerebral CortexPublisher: Oxford University Press (OUP)Vol: 25Issue #: 11Start Page: 4191End Page: 4202Publication Date:Open Access(OA) Status: OPENLicense: public-domainDOI - Digital Object Identifier: 10.1093/cercor/bhu142Best OA location URL: https://academic.oup.com/cercor/article-pdf/25/11/4191/7001061/bhu142.pdfCitation Count: 78
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OPENTitle: LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site statusJournal Name: Frontiers in Molecular NeurosciencePublisher: Frontiers Media SAVol: 7Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnmol.2014.00054Best OA location URL: https://www.frontiersin.org/articles/10.3389/fnmol.2014.00054/pdfCitation Count: 68
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OPENTitle: Overcoming obstacles to repurposing for neurodegenerative diseaseJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 1Issue #: 7Start Page: 512End Page: 518Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.76Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.76Citation Count: 56
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OPENTitle: Phenotypic characterization of recessive gene knockout rat models of Parkinson's diseaseJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 70Issue #:Start Page: 190End Page: 203Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-saDOI - Digital Object Identifier: 10.1016/j.nbd.2014.06.009Best OA location URL: https://doi.org/10.1016/j.nbd.2014.06.009Citation Count: 212
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OPENTitle: Differential protein–protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathwaysJournal Name: Journal of NeurochemistryPublisher: WileyVol: 131Issue #: 2Start Page: 239End Page: 250Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/jnc.12798Best OA location URL: https://europepmc.org/articles/pmc4272680?pdf=renderCitation Count: 51
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OPENTitle: Hyperplasticity in Autism Spectrum Disorder confers protection from Alzheimer’s diseaseJournal Name: Medical HypothesesPublisher: Elsevier BVVol: 83Issue #: 3Start Page: 337End Page: 342Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.mehy.2014.06.008Best OA location URL: https://europepmc.org/articles/pmc4392915?pdf=renderCitation Count: 46
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OPENTitle: Remote control of induced dopaminergic neurons in parkinsonian ratsJournal Name: Journal of Clinical InvestigationPublisher: American Society for Clinical InvestigationVol: 124Issue #: 7Start Page: 3215End Page: 3229Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1172/jci74664Best OA location URL: http://www.jci.org/articles/view/74664/files/pdfCitation Count: 115
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OPENTitle: A new approach to assess gambling-like behavior in laboratory rats: using intracranial self-stimulation as a positive reinforcerJournal Name: Frontiers in Behavioral NeurosciencePublisher: Frontiers Media SAVol: 8Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnbeh.2014.00215Best OA location URL: https://www.frontiersin.org/articles/10.3389/fnbeh.2014.00215/pdfCitation Count: 10
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OPENTitle: TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cordJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 128Issue #: 3Start Page: 423End Page: 437Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-014-1299-6Best OA location URL: https://europepmc.org/articles/pmc4384652?pdf=renderCitation Count: 230